Results 11 to 20 of about 3,991 (207)
Chemistry & Biology, 1996 Taxol is a natural product produced by the Pacific Yew, Taxus brevifolia, that has emerged as a prominent chemotherapeutic agent for the treatment of solid tumors. Taxol's biochemical mode of action has been well studied: it binds to microtubules, stabilizing them and preventing their depolymerization to tubulin subunits.
Guy, R.K. +3 more
openaire +3 more sources
Synthesis and Cytotoxicity of 7,9-O-Linked Macrocyclic C-Seco Taxoids
Molecules, 2019 A series of novel 7,9-O-linked macrocyclic taxoids together with modification at the C2 position were synthesized, and their cytotoxicities against drug-sensitive and P-glycoprotein and βIII-tubulin overexpressed drug-resistant cancer cell lines were ...
Yu Zhao +4 more
doaj +2 more sources
Paclitaxel biological synthesis promotes the innovation of anti-cancer drugs. [PDF]
Clin Transl MedClinical and Translational Medicine, Volume 15, Issue 2, February 2025.
Zhang X, Liu G, Yan J.
europepmc +2 more sources
Production of taxoids in callus and cell suspensions of Taxus chinensis by using abiotic elicitors
Biotecnología Vegetal, 2004 Until now, several strategies have been developed to improve the production of secondary metabolites using plant cell cultures, manipulating the parameters of the environment, selecting high yielding cell clones and the use of elicitors.
Naivy Pérez +4 more
doaj +1 more source
Electrosynthetic C−O Bond Activation in Alcohols and Alcohol Derivatives
Angewandte Chemie, Volume 135, Issue 4, January 23, 2023., 2023 Deoxygenative transformations of alcohols and their derivatives are often challenging due to the thermodynamic penalty associated with the cleavage of the C−O bond. This Review includes preparative protocols and their mechanistic aspects for the activation and functionalization of C−O bonds, detailing direct and indirect electrosynthetic methods, as ...
Piret Villo +3 more
wiley +2 more sources
Synthetic studies towards d-modified paclitaxel analogues [PDF]
Journal of the Serbian Chemical Society, 2012 A synthetic sequence has been developed for the preparation of 9,10-O-diacetyl-4-desmethylene-4β-(3-butenyl)-4α-hydroxy-5-O-mesyltaxicin I-1,2-carbonate 3, an intermediate in the attempted synthesis of cyclobutane paclitaxel analogue.
Matović Radomir +2 more
doaj +1 more source
Reactions of α-4(20)-epoxy-5-O-mesyltriacetyltaxicine I induced by Bf3·Et2O/Bu4NBr [PDF]
Journal of the Serbian Chemical Society, 2006 The reaction of α-4(20)-epoxy-5-O-mesyltriacetyltaxicine I (2) with BF3·Et2O/Bu4NBr can give rise to 4 different products. Each of these products can be obtained selectively, under the appropriate reaction conditions.
Ferjančić Zorana +3 more
doaj +1 more source
ChemElectroChem, Volume 10, Issue 22, November 14, 2023., 2023 Herein, electroreductive C−OH bond activation and subsequent deoxygenative C−H and C−C bond formation is demonstrated for non‐derivatized benzylic and propargylic alcohols. The cathodic transformations proceed via carbanions, formed via radical‐polar crossover, and are efficiently balanced by anodic oxidation of borohydride additives, a strategy that ...
Piret Villo +8 more
wiley +1 more source
Synthesis and Structure‐Activity Relationship Studies of C(13)‐Desmethylene‐(−)‐Zampanolide Analogs
Chemistry – A European Journal, Volume 29, Issue 36, June 27, 2023., 2023 Reduced or demethylated variants of a C(13)‐desmethylene congener of the marine microtubule stabilizer (−)‐zampanolide have been prepared by HWE‐based macrocyclization and stereoselective construction of the hemiaminal center in the side chain. While all modifications led to reduced growth inhibitory activity, the 2,3‐dihydro and the C(17)‐desmethyl ...
Tobias M. Brütsch +10 more
wiley +1 more source
PLoS ONE, 2023 Although bioproduction of Paclitaxel by endophytic fungi is highly considered as an alternative promising source, but its yield is usually very low in comparison with other taxoids.
Narjes Mohammadi Ballakuti +1 more
doaj +2 more sources