Results 11 to 20 of about 3,403 (164)

Transcriptome and comparative chloroplast genome analysis of Taxus yunnanensis individuals with high and low paclitaxel yield [PDF]

Heliyon
Paclitaxel is a potent anti-cancer drug that is mainly produced through semi-synthesis, which still requires plant materials as precursors. The content of paclitaxel and 10-deacetyl baccatin III (10-DAB) in Taxus yunnanensis has been found to differ from
Dong Wang, Jiansheng Wei, Xiaolong Yuan, Zhonghua Chen, Lei Wang, Yunfen Geng, Jinfeng Zhang, Yi Wang   +7 more
doaj   +2 more sources

Electrosynthetic C−O Bond Activation in Alcohols and Alcohol Derivatives

Angewandte Chemie, Volume 135, Issue 4, January 23, 2023., 2023
Deoxygenative transformations of alcohols and their derivatives are often challenging due to the thermodynamic penalty associated with the cleavage of the C−O bond. This Review includes preparative protocols and their mechanistic aspects for the activation and functionalization of C−O bonds, detailing direct and indirect electrosynthetic methods, as ...
Piret Villo, Andrey Shatskiy, Markus D. Kärkäs, Helena Lundberg   +3 more
wiley   +2 more sources

Omic analysis of the endangered Taxaceae species Pseudotaxus chienii revealed the differences in taxol biosynthesis pathway between Pseudotaxus and Taxus yunnanensis trees

BMC Plant Biology, 2021
Background Taxol is an efficient anticancer drug accumulated in Taxus species. Pseudotaxus chienii is an important member of Taxaceae, however, the level of six taxoids in P. chienii is largely unknown. Results High accumulation of 10-DAB, taxol, and 7-E-
Chunna Yu, Chengchao Zhang, Xinyun Xu, Jiefang Huang, Yueyue Chen, Xiujun Luo, Huizhong Wang, Chenjia Shen   +7 more
doaj   +1 more source

Reactions of α-4(20)-epoxy-5-O-mesyltriacetyltaxicine I induced by Bf3·Et2O/Bu4NBr [PDF]

Journal of the Serbian Chemical Society, 2006
The reaction of α-4(20)-epoxy-5-O-mesyltriacetyltaxicine I (2) with BF3·Et2O/Bu4NBr can give rise to 4 different products. Each of these products can be obtained selectively, under the appropriate reaction conditions.
Ferjančić Zorana, Matović Radomir, Čeković Živorad, Saičić Radomir N.   +3 more
doaj   +1 more source

Synthetic studies towards d-modified paclitaxel analogues [PDF]

Journal of the Serbian Chemical Society, 2012
A synthetic sequence has been developed for the preparation of 9,10-O-diacetyl-4-desmethylene-4β-(3-butenyl)-4α-hydroxy-5-O-mesyltaxicin I-1,2-carbonate 3, an intermediate in the attempted synthesis of cyclobutane paclitaxel analogue.
Matović Radomir, Saičić Radomir N., Ferjančić Zorana   +2 more
doaj   +1 more source

Electroreductive Deoxygenative C−H and C−C Bond Formation from Non‐Derivatized Alcohols Fueled by Anodic Borohydride Oxidation

ChemElectroChem, Volume 10, Issue 22, November 14, 2023., 2023
Herein, electroreductive C−OH bond activation and subsequent deoxygenative C−H and C−C bond formation is demonstrated for non‐derivatized benzylic and propargylic alcohols. The cathodic transformations proceed via carbanions, formed via radical‐polar crossover, and are efficiently balanced by anodic oxidation of borohydride additives, a strategy that ...
Piret Villo, Malin Lill, Zainab Alsaman, Adrian Soto Kronberg, Victoria Chu, Guillermo Ahumada, Hemlata Agarwala, Mårten Ahlquist, Helena Lundberg   +8 more
wiley   +1 more source

Developed network between taxoid and phenylpropanoid pathways in Cryptosporiopsis tarraconensis, taxan-producing endophytic fungus by Debiased Sparse Partial Correlation (DSPC) algorithm

PLoS ONE, 2023
Although bioproduction of Paclitaxel by endophytic fungi is highly considered as an alternative promising source, but its yield is usually very low in comparison with other taxoids.
Narjes Mohammadi Ballakuti, Faezeh Ghanati   +1 more
doaj   +2 more sources

Synthesis and Structure‐Activity Relationship Studies of C(13)‐Desmethylene‐(−)‐Zampanolide Analogs

Chemistry – A European Journal, Volume 29, Issue 36, June 27, 2023., 2023
Reduced or demethylated variants of a C(13)‐desmethylene congener of the marine microtubule stabilizer (−)‐zampanolide have been prepared by HWE‐based macrocyclization and stereoselective construction of the hemiaminal center in the side chain. While all modifications led to reduced growth inhibitory activity, the 2,3‐dihydro and the C(17)‐desmethyl ...
Tobias M. Brütsch, Etienne Cotter, Daniel Lucena‐Agell, Mariano Redondo‐Horcajo, Carolina Davies, Bernhard Pfeiffer, Sandro Pagani, Simone Berardozzi, J. Fernando Díaz, John H. Miller, Karl‐Heinz Altmann   +10 more
wiley   +1 more source

Role of Taxoids in Head and Neck Cancer [PDF]

The Oncologist, 2000
Abstract Docetaxel and paclitaxel represent a new class of cytotoxic agents having both a specific chemical structure and mechanism of action. They act to promote tubulin polymerization and the formation of stable microtubules. The microtubules produced in the presence of taxoids are resistant to disassembly by physiologic stimuli, and ...
Schrijvers, D., Vermorken, J.B.
openaire   +3 more sources

Response of Patients with Taxane‐Refractory Advanced Urothelial Cancer to Enfortumab Vedotin, a Microtubule‐Disrupting Agent

Case Reports in Urology, Volume 2023, Issue 1, 2023., 2023
Enfortumab vedotin (EV), a nectin‐4‐directed antibody conjugated to monomethyl auristatin E (MMAE), has been approved for patients with advanced urothelial carcinoma (aUC) previously treated with platinum‐based chemotherapy and immune inhibitors. Taxane agents and MMAE share antitumor mechanisms through microtubule disruption, thus raising a notable ...
Makito Miyake, Nobutaka Nishimura, Tatsuki Miyamoto, Takuto Shimizu, Kenta Ohnishi, Shunta Hori, Yosuke Morizawa, Daisuke Gotoh, Yasushi Nakai, Kazumasa Torimoto, Tomomi Fujii, Kiyohide Fujimoto, Fumitaka Koga   +12 more
wiley   +1 more source