Frontiers in Plant Science, 2022 Paclitaxel (Taxol), a highly modified diterpene agent mainly obtained from Taxus species, is the most widely used anticancer drug. Abscisic acid (ABA) is a well-known stress hormone that plays important roles in the secondary metabolism of plants, and it
Xiaoying Cao +4 more
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TAXOL INDUCES CELL DEATH WITH CYTOPLASM VACUOLIZATION IN PARAPTOSIS-LIKE BUT NOT ONCOSIS FASHION IN ASTC-a-1 CELLS [PDF]
Journal of Innovative Optical Health Sciences, 2013 Recently, we found that high concentration of taxol (70 μM) induced cell death with cytoplasm vacuolization, the typical characteristic of both paraptosis and oncosis, in human lung carcinoma (ASTC-a-1) cells.
YING-YAO QUAN +3 more
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Upregulation of miR-129-5p increases the sensitivity to Taxol through inhibiting HMGB1-mediated cell autophagy in breast cancer MCF-7 cells [PDF]
Brazilian Journal of Medical and Biological ResearchAlthough Taxol has improved the survival of cancer patients as a first-line chemotherapeutic agent, an increasing number of patients develop resistance to Taxol after prolonged treatment.
Ying Shi +4 more
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Frontiers in Pharmacology, 2019 Purpose: The purpose of this study was to determine if an Astragalus polysaccharide (RAP) can protect immune cells from the toxic side effects of paclitaxel (Taxol), a powerful anti-tumor drug whose equally powerful side effects limit its clinical use ...
Wan-Rong Bao +9 more
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Taxol production by Fusarium arthrosporioides isolated from yew, Taxus cuspidata [PDF]
Journal of Medical Biochemistry, 2008 A taxol-producing endophyte was Fusarium arthrosporioides. As a novel taxol resource, a taxol-producing endophyte was successfully isolated from the yew tree, Taxus cuspidata Sieb. et Zucc.
Chang-Tian Li +3 more
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Iso-Seq analysis of the Taxus cuspidata transcriptome reveals the complexity of Taxol biosynthesis
BMC Plant Biology, 2019 Background Taxus cuspidata is well known worldwide for its ability to produce Taxol, one of the top-selling natural anticancer drugs. However, current Taxol production cannot match the increasing needs of the market, and novel strategies should be ...
Xuejun Kuang +4 more
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Enantioselective Total Synthesis of (−)-Taxol
, 2016 Enantioselective total synthesis of taxol has been accomplished. Coupling reaction of the optically pure A-ring hydroxy aldehyde with the aromatic C-ring fragment followed by Lewis acid mediated eight-membered B-ring cyclization gave the desired ABC endo-
Nobuhito Nakamura (3005613) +7 more
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Asymmetric Total Synthesis of Taxol
, 2021 Taxol is one of the most famous natural diterpenoids and an important anticancer medicine. Taxol represents a formidable synthetic challenge and has prompted significant interest from the synthetic community.
Ya-Jian Hu +9 more
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The role of gold nanoparticles on taxol-induced renal cortex damage in adult male albino rats [PDF]
The Egyptian Journal of Histology, 2018 Introduction: Taxol is a chemotherapeutic drug widely used in the treatment of various types of cancer. Nephrotoxicity is themost hazardous effect complicating chemotherapy.Aim of the work: This research aimed to evaluate the effect of gold nanoparticles
Abeer Mahmoud +2 more
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Ecophysiological approaches to enhance production of the anti-cancer drug taxol by paraconiothyrium variabile and epiccocum nigrum and lysozyme by pichia pastoris [PDF]
, 2013 This study has investigated the interaction of ecophysiological factors such as water activity (aw), temperature, pH and solute types on (a) the production of the anti-cancer drug taxol by the endophytic fungi Parachoniothyrium variabile and Epcoccum ...
Somjaipeng, Supunnika
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