Results 1 to 10 of about 228,669 (188)

TcMYB29a, an ABA-Responsive R2R3-MYB Transcriptional Factor, Upregulates Taxol Biosynthesis in Taxus chinensis [PDF]

Frontiers in Plant Science, 2022
Paclitaxel (Taxol), a highly modified diterpene agent mainly obtained from Taxus species, is the most widely used anticancer drug. Abscisic acid (ABA) is a well-known stress hormone that plays important roles in the secondary metabolism of plants, and it
Ludan Li
exaly   +4 more sources

Salicylic Acid-Responsive Factor TcWRKY33 Positively Regulates Taxol Biosynthesis in Taxus chinensis in Direct and Indirect Ways [PDF]

Frontiers in Plant Science, 2021
Taxol is a rare secondary metabolite that accumulates considerably in Taxus species under salicylic acid (SA) and methyl jasmonate treatment. However, the molecular mechanism of its accumulation remains unclear.
Meng Zhang, Chün-Fang Zhao, Longjiang Yu   +2 more
exaly   +4 more sources

TcMYC2a, a Basic Helix–Loop–Helix Transcription Factor, Transduces JA-Signals and Regulates Taxol Biosynthesis in Taxus chinensis [PDF]

Frontiers in Plant Science, 2018
The multitherapeutic taxol, which can be obtained from Taxus spp., is the most widely used anticancer drug. Taxol biosynthesis is significantly regulated by jasmonate acid (JA), one of the most important endogenous hormones in land plants.
Meng Zhang, Meng Zhang, Xiaofei Jin, Xiaofei Jin, Ying Chen, Ying Chen, Mi Wei, Mi Wei, Weifang Liao, Weifang Liao, Shengying Zhao, Shengying Zhao, Chunhua Fu, Chunhua Fu, Longjiang Yu, Longjiang Yu   +15 more
doaj   +4 more sources

Endophytic fungus Pseudodidymocyrtis lobariellae KL27 promotes taxol biosynthesis and accumulation in Taxus chinensis [PDF]

BMC Plant Biology, 2022
Background Taxol from Taxus species is a precious drug used for the treatment of cancer and can effectively inhibit the proliferation of cancer cells. However, the growth of Taxus plants is very slow and the content of taxol is quite low.
Xiaoying Cao, Lingxia Xu, Jingyi Wang, Mengmeng Dong, Chunyan Xu, Guoyin Kai, Wen Wan, Jihong Jiang   +7 more
doaj   +2 more sources

Omic analysis of the endangered Taxaceae species Pseudotaxus chienii revealed the differences in taxol biosynthesis pathway between Pseudotaxus and Taxus yunnanensis trees [PDF]

BMC Plant Biology, 2021
Background Taxol is an efficient anticancer drug accumulated in Taxus species. Pseudotaxus chienii is an important member of Taxaceae, however, the level of six taxoids in P. chienii is largely unknown. Results High accumulation of 10-DAB, taxol, and 7-E-
Chunna Yu, Chengchao Zhang, Xinyun Xu, Jiefang Huang, Yueyue Chen, Xiujun Luo, Huizhong Wang, Chenjia Shen   +7 more
doaj   +2 more sources

Iso-Seq analysis of the Taxus cuspidata transcriptome reveals the complexity of Taxol biosynthesis [PDF]

BMC Plant Biology, 2019
Background Taxus cuspidata is well known worldwide for its ability to produce Taxol, one of the top-selling natural anticancer drugs. However, current Taxol production cannot match the increasing needs of the market, and novel strategies should be ...
Xuejun Kuang, Sijie Sun, Jianhe Wei, Ying Li, Chao Sun   +4 more
doaj   +2 more sources

Transcriptome analyses provide insights into the expression pattern and sequence similarity of several taxol biosynthesis-related genes in three Taxus species [PDF]

BMC Plant Biology, 2019
Background Taxol is an efficient anticancer drug; however, the accumulation of taxoids can vary hugely among Taxus species. The mechanism underlying differential accumulation of taxoids is largely unknown. Thus, comparative analysis of the transcriptomes
Ting Zhou, Xiujun Luo, Chunna Yu, Chengchao Zhang, Lei Zhang, Yao-bin Song, Ming Dong, Chenjia Shen   +7 more
doaj   +2 more sources

Recent advances in Taxus molecular research: applications in genetic diversity, gene function and metabolic engineering [PDF]

Frontiers in Plant Science
Plants belonging to the genus Taxus are abundant in pharmacologically active constituents, notably Taxol (paclitaxel), which has been extensively employed in the treatment of various cancers.
Yan Jiang, Lingxiao Zhang, Huijie Ma, Zijin Fang, Chunna Yu, Xiaori Zhan, Yanjun Yang, Chenjia Shen, Chenjia Shen   +8 more
doaj   +2 more sources

Genome-Wide Analysis of bZIP Transcription Factors and Expression Patterns in Response to Shading Treatment in Taxus yunnanensis [PDF]

Current Issues in Molecular Biology
Basic leucine zipper (bZIP) transcription factors are widely involved in plant growth, development, environmental adaptation, and secondary metabolism. However, the bZIP gene family in Taxus yunnanensis has not been systematically characterized, and its ...
Jiangtao Fan, Pengpeng Gong, Yujia Liu, Mengke Dou, Qing Li, Qiuhong Hu, Yong Wang, Gang Wang, Xiong Huang   +8 more
doaj   +2 more sources

Analysis genome of Pseudotaxus chienii reveals insights into the origin and evolution of taxane biosynthesis [PDF]

Nature Communications
As a sister genus to Taxus, Pseudotaxus holds significant importance for studying the origin and evolution of the taxane biosynthesis pathway. However, the reference genome of Pseudotaxus chienii is yet unavailable.
Mingshuang Wang, Ruoyun Ma, Zijin Fang, Lingxiao Zhang, Yibo Zhang, Mengyin Zheng, Enhui Bai, Wanting Lin, Yanyan Pei, Yue Zang, Huijie Ma, Shangguo Feng, Xiaori Zhan, Chunna Yu, Shuling Wang, Huizhong Wang, Chenliang Yu, Chenjia Shen   +17 more
doaj   +2 more sources