Results 1 to 10 of about 244,215 (151)

Biosynthesis of the highly oxygenated tetracyclic core skeleton of Taxol

Nature Communications
Taxol is a widely-applied anticancer drug that inhibits microtubule dynamics in actively replicating cells. Although a minimum 19-step biosynthetic pathway has been proposed and 16 enzymes likely involved have been characterized, stepwise biosynthetic ...
Chengshuai Yang, Yan Wang, Zhen Su, Lunyi Xiong, Pingping Wang, Wen Lei, Xing Yan, Dawei Ma, Guoping Zhao, Zhihua Zhou   +9 more
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Fungal endophytes of Taxus species and regulatory effect of two strains on taxol synthesis

BMC Microbiology
Background Taxol, derived from Taxus trees, is a valuable natural resource for the development of anticancer drugs. Endophytic fungi from Taxus trees are a promising alternative source of Taxol.
Hongshan Zhang, Wanting Lin, Ruoyun Ma, Yue Zang, Kailin Hou, Zhen Xu, Xiaoyun Xi, Weiting Zhang, Shini Tang, Xueshuang Liang, Yiming Sun, Chenjia Shen   +11 more
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Use of endophytic fungi in the Taxol anticancer drug production

Biotecnología Vegetal, 2014
Taxol is a drug used in the chemotherapy of breast, lung, ovarian, prostate, liver cancers, and in the treatment of rheumatoid arthritis. Taxol is obtained from Taxus spp. trees. It is found in low concentrations in the bark, needles and roots.
Hebert Jair Barrales-Cureño, Raqueline de la Rosa Montoya   +1 more
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Metabolic Engineering of Bacillus subtilis Toward Taxadiene Biosynthesis as the First Committed Step for Taxol Production [PDF]

Frontiers in Microbiology, 2019
Terpenoids are natural products known for their medicinal and commercial applications. Metabolic engineering of microbial hosts for the production of valuable compounds, such as artemisinin and Taxol, has gained vast interest in the last few decades. The
Ingy I. Abdallah, Hegar Pramastya, Hegar Pramastya, Ronald van Merkerk, Sukrasno, Wim J. Quax   +5 more
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Interactions between co-habitating fungi elicit synthesis of Taxol from an endophytic fungus in host Taxus plants

Frontiers in Microbiology, 2013
Within a plant, there can exist an ecosystem of pathogens and endophytes, the latter described as bacteria and fungal inhabitants that thrive without causing disease to the host.
Sameh S.M. Soliman, Manish N Raizada
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A re-assessment of Taxomyces andreanae, the alleged taxol-producing fungus, using comparative genomics

IMA Fungus, 2022
The monotypic “bulbilliferous hyphomycete” genus Taxomyces was erected in 1993 for a fungal endophyte isolated from the Yew tree Taxus brevifolia and named Taxomyces andreanae. This fungus was reported to produce the plant-derived anti-cancer drug taxol.
Tian Cheng, Miroslav Kolařík, Luis Quijada, Marc Stadler   +3 more
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Deep sequencing reveals transcriptome re-programming of Taxus × media cells to the elicitation with methyl jasmonate. [PDF]

PLoS ONE, 2013
Plant cell culture represents an alternative source for producing high-value secondary metabolites including paclitaxel (Taxol®), which is mainly produced in Taxus and has been widely used in cancer chemotherapy.
Guiling Sun, Yanfang Yang, Fuliang Xie, Jian-Fan Wen, Jianqiang Wu, Iain W Wilson, Qi Tang, Hongwei Liu, Deyou Qiu   +8 more
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Hazel (Corylus avellana L.) as a New Source of Taxol and Taxanes

Journal of Medicinal Plants, 2012
Taxol is used to treatment of variety cancers including ovarian, breast, lung, head and neck carcinomas and the AIDS-related Karposi’s carcinoma, and was originally obtained from bark of taxus brevifolia.
A Qaderi, M Omidi, A Etminan, A Oladzad, C Ebrahimi, MR Dehghani Mashkani, A Mehrafarin   +6 more
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Recent advances in Taxus molecular research: applications in genetic diversity, gene function and metabolic engineering

Frontiers in Plant Science
Plants belonging to the genus Taxus are abundant in pharmacologically active constituents, notably Taxol (paclitaxel), which has been extensively employed in the treatment of various cancers.
Yan Jiang, Lingxiao Zhang, Huijie Ma, Zijin Fang, Chunna Yu, Xiaori Zhan, Yanjun Yang, Chenjia Shen, Chenjia Shen   +8 more
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A Review on Taxol Production through Biotechnological Approaches

Journal of Medicinal Plants, 2018
Taxol is a very important anticancer drug which was first isolated from Yew plant (Taxus spp.). However, Taxol supply by extraction from natural sources, has several limitations, and cannot meet current marketchr('39')s demands.
M Majidi, AR tarinejad
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