Results 11 to 20 of about 244,215 (151)
Frontiers in Plant Science, 2021 Taxol is a rare secondary metabolite that accumulates considerably in Taxus species under salicylic acid (SA) and methyl jasmonate treatment. However, the molecular mechanism of its accumulation remains unclear.
Meng Zhang, Chun-Fang Zhao, Longjiang Yu
exaly +3 more sources
Frontiers in Plant Science, 2022 Paclitaxel (Taxol), a highly modified diterpene agent mainly obtained from Taxus species, is the most widely used anticancer drug. Abscisic acid (ABA) is a well-known stress hormone that plays important roles in the secondary metabolism of plants, and it
Ludan Li, Wen Wan
exaly +3 more sources
Molecules, 2020 Taxol is one of the potential anticancer drugs; however, the yield of Taxol and its cytotoxicity are common challenges. Thus, manipulating the Taxol biosynthetic pathway from endophytic fungi, in addition to chemical modification with biocompatible ...
Ashraf S. A. El-Sayed +6 more
doaj +2 more sources
A molecular approach to taxol biosynthesis [PDF]
, 2012 Secondary metabolism in plants produces numerous compounds with wide-ranging activities, including the antineoplastic compound taxol and related taxanes. The biotechnological production of taxol has so far been based on empirical studies. The aim of the present work has been to study how the factors that enhance taxane production affect the metabolic ...
Onrubia Ibáñez, Miriam
core +3 more sources
Transcriptome analysis of a taxol-producing endophytic fungus Cladosporium cladosporioides MD2
AMB Express, 2018 The shortage of molecular information for taxol-producing fungi has greatly impeded the understanding of fungal taxol biosynthesis mechanism. In this study, the transcriptome of one taxol-producing endophytic fungus Cladosporium cladosporioides MD2 was ...
Li-Yun Miao +9 more
doaj +2 more sources
BMC Plant Biology, 2019 Background Taxol is an efficient anticancer drug; however, the accumulation of taxoids can vary hugely among Taxus species. The mechanism underlying differential accumulation of taxoids is largely unknown. Thus, comparative analysis of the transcriptomes
Ting Zhou +7 more
doaj +2 more sources
TcMYC2a, a Basic Helix–Loop–Helix Transcription Factor, Transduces JA-Signals and Regulates Taxol Biosynthesis in Taxus chinensis [PDF]
Frontiers in Plant Science, 2018 The multitherapeutic taxol, which can be obtained from Taxus spp., is the most widely used anticancer drug. Taxol biosynthesis is significantly regulated by jasmonate acid (JA), one of the most important endogenous hormones in land plants.
Meng Zhang +15 more
doaj +2 more sources
Darkness: A Crucial Factor in Fungal Taxol Production
Frontiers in Microbiology, 2018 Fungal Taxol acquired lots of attention in the last few decades mainly because of the hope that fungi could be manipulated more easily than yew trees to scale up the production level of this valuable anticancer drug.
Sameh S. M. Soliman +3 more
doaj +2 more sources
Ecophysiological approaches to enhance production of the anti-cancer drug taxol by paraconiothyrium variabile and epiccocum nigrum and lysozyme by pichia pastoris [PDF]
, 2013 This study has investigated the interaction of ecophysiological factors such as water activity (aw), temperature, pH and solute types on (a) the production of the anti-cancer drug taxol by the endophytic fungi Parachoniothyrium variabile and Epcoccum ...
Somjaipeng, Supunnika
core +7 more sources
Taxol® Biosynthesis and Production: From Forests to Fermenters
, 2017 Taxol® (paclitaxel) has fascinated researchers, medical professionals, politicians and entrepreneurs for almost half a century. Its medicinal value as a potent anti-cancer compound has expanded greatly over time as new applications have been identified for the treatment of diverse indications.
Christopher McElroy, Stefan Jennewein
openaire +2 more sources