Engineering of 10-Deacetylbaccatin III-10-β-O-Acetyltransferase From Taxus Species for Efficient Acetylating Non-Natural Substrates Into Taxol in Nicotiana benthamiana. [PDF]
Plant Biotechnol JABSTRACT 7‐β‐xylosyl‐10‐deacetyltaxol (XDT) is much more abundant than the anticancer drug Taxol in Taxus species and is usually regarded as the by‐product of Taxol. It could be enzymatically transformed into 10‐deacetyltaxol (DT), and the latter could be further converted into Taxol.
Chen TJ +5 more
europepmc +2 more sources
Chemistry & Biology, 2004 Cytochrome P450 monooxygenases play a prominent role in the biosynthesis of the diterpenoid anticancer drug Taxol, as they appear to constitute about half of the 19 enzymatic steps of the pathway in yew (Taxus) species. A combination of classical biochemical and molecular methods, including cell-free enzyme studies and differential-display of mRNA ...
Chau, MyDoanh +3 more
openaire +4 more sources
Frontiers in Plant Science, 2022 Taxol is a precious and effective anticancer drug. Cerium and methyl jasmonate (MJ) have been shown to increase the yield of taxol in taxus cells. However, the mechanisms of cerium-mediated and MJ-mediated taxol biosynthesis remain unknown.
Na Han +9 more
doaj +1 more source
Baseline survey of root-associated microbes of Taxus chinensis (Pilger) Rehd. [PDF]
PLoS ONE, 2015 Taxol (paclitaxel) a diterpenoid is one of the most effective anticancer drugs identified. Biosynthesis of taxol was considered restricted to the Taxus genera until Stierle et al.
Qian Zhang +7 more
doaj +1 more source
Data_Sheet_2_TcMYB29a, an ABA-Responsive R2R3-MYB Transcriptional Factor, Upregulates Taxol Biosynthesis in Taxus chinensis.docx [PDF]
, 2022 Paclitaxel (Taxol), a highly modified diterpene agent mainly obtained from Taxus species, is the most widely used anticancer drug. Abscisic acid (ABA) is a well-known stress hormone that plays important roles in the secondary metabolism of plants, and it
Xiaoying Cao (10581624) +4 more
core +1 more source
Data_Sheet_1_TcMYB29a, an ABA-Responsive R2R3-MYB Transcriptional Factor, Upregulates Taxol Biosynthesis in Taxus chinensis.PDF [PDF]
, 2022 Paclitaxel (Taxol), a highly modified diterpene agent mainly obtained from Taxus species, is the most widely used anticancer drug. Abscisic acid (ABA) is a well-known stress hormone that plays important roles in the secondary metabolism of plants, and it
Xiaoying Cao (10581624) +4 more
core +1 more source
Table_1_Salicylic Acid-Responsive Factor TcWRKY33 Positively Regulates Taxol Biosynthesis in Taxus chinensis in Direct and Indirect Ways.XLSX [PDF]
, 2021 Taxol is a rare secondary metabolite that accumulates considerably in Taxus species under salicylic acid (SA) and methyl jasmonate treatment. However, the molecular mechanism of its accumulation remains unclear.
Meng Zhang (154027) +8 more
core +1 more source
Additional file 15 of Endophytic fungus Pseudodidymocyrtis lobariellae KL27 promotes taxol biosynthesis and accumulation in Taxus chinensis [PDF]
, 2022 Additional file 15: Table S8.
Xiaoying Cao (10581624) +7 more
core +1 more source
, 2016 Being a complex diterpenoid, the potent anticancer drug, Taxol, requires complicated steps for its biosynthesis. In the present article, recent advances on Taxol biosynthesis pathway are reviewed, including many recently reported genes that regulate ...
Jin, HB, Tang, KX, Guo, BH, Kai, GY
core +2 more sources
BMC Genomics, 2020 Background Taxus cells are a potential sustainable and environment-friendly source of taxol, but they have low survival ratios and slow grow rates. Despite these limitations, Taxus callus cells induced through 6 months of culture contain more taxol than ...
Ying Chen +7 more
doaj +1 more source