Results 31 to 40 of about 244,215 (151)

Transcriptional reprogramming strategies and miRNA-mediated regulation networks of Taxus media induced into callus cells from tissues

BMC Genomics, 2020
Background Taxus cells are a potential sustainable and environment-friendly source of taxol, but they have low survival ratios and slow grow rates. Despite these limitations, Taxus callus cells induced through 6 months of culture contain more taxol than ...
Ying Chen, Meng Zhang, Xiaofei Jin, Haoran Tao, Yamin Wang, Bo Peng, Chunhua Fu, Longjiang Yu   +7 more
doaj   +1 more source

Recent Research Progress in Taxol Biosynthetic Pathway and Acylation Reactions Mediated by Taxus Acyltransferases

Molecules, 2021
Taxol is one of the most effective anticancer drugs in the world that is widely used in the treatments of breast, lung and ovarian cancer. The elucidation of the taxol biosynthetic pathway is the key to solve the problem of taxol supply.
Tao Wang, Lingyu Li, Weibing Zhuang, Fengjiao Zhang, Xiaochun Shu, Ning Wang, Zhong Wang   +6 more
doaj   +1 more source

Additional file 15 of Endophytic fungus Pseudodidymocyrtis lobariellae KL27 promotes taxol biosynthesis and accumulation in Taxus chinensis

, 2022
Additional file 15: Table S8.
Xiaoying Cao (10581624), Guoyin Kai (1440943), Lingxia Xu (9200528), Chunyan Xu (276999), Wen Wan (95714), Jingyi Wang (550305), Mengmeng Dong (4540903), Jihong Jiang (453444)   +7 more
core   +1 more source

Iso-Seq analysis of the Taxus cuspidata transcriptome reveals the complexity of Taxol biosynthesis

BMC Plant Biology, 2019
Background Taxus cuspidata is well known worldwide for its ability to produce Taxol, one of the top-selling natural anticancer drugs. However, current Taxol production cannot match the increasing needs of the market, and novel strategies should be ...
Xuejun Kuang, Sijie Sun, Jianhe Wei, Ying Li, Chao Sun   +4 more
doaj   +1 more source

Elimination of enzymes catalysis compartmentalization enhancing taxadiene production in Saccharomyces cerevisiae

Frontiers in Bioengineering and Biotechnology, 2023
Taxadiene is an important precursor in taxol biosynthesis pathway, but its biosynthesis in eukaryotic cell factories is limited, which seriously hinders the biosynthesis of taxol.
Chenglong Zhang, Wang Chen, Tianyu Dong, Ying Wang, Mingdong Yao, Wenhai Xiao, Wenhai Xiao, Bingzhi Li   +7 more
doaj   +1 more source

Recent Advances in Metabolic Engineering, Protein Engineering, and Transcriptome-Guided Insights Toward Synthetic Production of Taxol

Frontiers in Bioengineering and Biotechnology, 2021
The diterpenoid paclitaxel (Taxol®) is a blockbuster anticancer agent that was originally isolated from the Pacific yew (Taxus brevifolia) five decades ago.
Ishmael Mutanda, Jianhua Li, Fanglin Xu, Fanglin Xu, Fanglin Xu, Yong Wang   +5 more
doaj   +1 more source

Review - Taxol synthesis [PDF]

, 2006
Being a complex diterpenoid, the potent anticancer drug, Taxol, requires complicated steps for its biosynthesis. In the present article, recent advances on Taxol biosynthesis pathway are reviewed, including many recently reported genes that regulate ...
K. X. Tang, H. B. Jin, B. H. Guo, G. Y. Kai   +3 more
core   +1 more source

Transcriptome Sequencing Reveals Regulatory Mechanisms of Taxol Synthesis in Taxus wallichiana var. Mairei

International Journal of Genomics, 2019
Taxol is one of the most potent and effective anticancer drugs and is originally isolated from Taxus species. To investigate the specific regulatory mechanisms of taxol synthesis in Taxus wallichiana var.
Tao Wang, Yiming Chen, Weibing Zhuang, Fengjiao Zhang, Xiaochun Shu, Zhong Wang, Qing Yang   +6 more
doaj   +1 more source

Purification and Biochemical Characterization of Taxadiene Synthase from Bacillus koreensis and Stenotrophomonas maltophilia

Scientia Pharmaceutica, 2021
Taxadiene synthase (TDS) is the rate-limiting enzyme of Taxol biosynthesis that cyclizes the geranylgeranyl pyrophosphate into taxadiene. Attenuating Taxol productivity by fungi is the main challenge impeding its industrial application; it is possible ...
Ashraf S. A. El-Sayed, Maher Fathalla, Ahmed A. Shindia, Amgad M. Rady, Ashraf F. El-Baz, Yara Morsy, Basel Sitohy, Mahmoud Sitohy   +7 more
doaj   +1 more source

Transcriptional profile of Taxus chinensis cells in response to methyl jasmonate

BMC Genomics, 2012
Background Methyl jasmonate (MeJA) has been successfully used as an effective elicitor to enhance production of taxol and other taxanes in cultured Taxus cells. However the mechanism of MeJA-mediated taxane biosynthesis remains unclear.
Li Shu-tao, Zhang Peng, Zhang Meng, Fu Chun-hua, Zhao Chun-fang, Dong Yan-shan, Guo An-yuan, Yu Long-jiang   +7 more
doaj   +1 more source