Results 31 to 40 of about 3,967 (187)

Analysis genome of Pseudotaxus chienii reveals insights into the origin and evolution of taxane biosynthesis [PDF]

Nature Communications
As a sister genus to Taxus, Pseudotaxus holds significant importance for studying the origin and evolution of the taxane biosynthesis pathway. However, the reference genome of Pseudotaxus chienii is yet unavailable.
Mingshuang Wang, Ruoyun Ma, Zijin Fang, Lingxiao Zhang, Yibo Zhang, Mengyin Zheng, Enhui Bai, Wanting Lin, Yanyan Pei, Yue Zang, Huijie Ma, Shangguo Feng, Xiaori Zhan, Chunna Yu, Shuling Wang, Huizhong Wang, Chenliang Yu, Chenjia Shen   +17 more
doaj   +2 more sources

Amesia nigricolor, a novel endophyte of Encephalartos bubalinus, exhibiting a robust taxol biosynthetic stability: chemical characterization and biological activities [PDF]

Microbial Cell Factories
Diminishing the productivity of Taxol by the potential fungi with storage is the key hurdle that impedes their applications to be an industrial platform for Taxol production.
Asmaa Gamal, Ashraf S. A. El-Sayed, Eman Fikry, Nora Tawfeek, Azza M. El-Shafae, Maher M. El-Domiaty   +5 more
doaj   +2 more sources

Darkness: A Crucial Factor in Fungal Taxol Production [PDF]

Frontiers in Microbiology, 2018
Fungal Taxol acquired lots of attention in the last few decades mainly because of the hope that fungi could be manipulated more easily than yew trees to scale up the production level of this valuable anticancer drug.
Sameh S. M. Soliman, Sameh S. M. Soliman, Sameh S. M. Soliman, Manish N. Raizada   +3 more
doaj   +2 more sources

Cloning and Sequencing of Hydroxylase Genes Involved in Taxol Biosynthesis

Zeitschrift Fur Naturforschung - Section C Journal of Biosciences, 2004
Abstract Two full-length cDNAs (TCH1 and TCH2) were obtained from a cDNA library of Taxus chinensis mainly by the single specific-primer PCR (SSP-PCR) method. Compared with other reported enzymes from Taxus species, the deduced amino acid sequences of TCH1 and TCH2 exhibit significant homologies to hydroxylases that are involved in taxol
Ping Zhu, Jun Tu
exaly   +3 more sources

Metabolic Engineering of Bacillus subtilis Toward Taxadiene Biosynthesis as the First Committed Step for Taxol Production [PDF]

Frontiers in Microbiology, 2019
Terpenoids are natural products known for their medicinal and commercial applications. Metabolic engineering of microbial hosts for the production of valuable compounds, such as artemisinin and Taxol, has gained vast interest in the last few decades. The
Ingy I. Abdallah, Hegar Pramastya, Hegar Pramastya, Ronald van Merkerk, Sukrasno, Wim J. Quax   +5 more
doaj   +3 more sources

A molecular approach to taxol biosynthesis [PDF]

, 2012
Secondary metabolism in plants produces numerous compounds with wide-ranging activities, including the antineoplastic compound taxol and related taxanes. The biotechnological production of taxol has so far been based on empirical studies. The aim of the present work has been to study how the factors that enhance taxane production affect the metabolic ...
Onrubia Ibáñez, Miriam
core   +5 more sources

Salicylic acid as an effective elicitor for improved taxol production in endophytic fungus Pestalotiopsis microspora. [PDF]

PLoS ONE, 2019
Salicylic acid (SA) is an effective elicitor to increase taxol production in Pestalotiopsis microspora. Addition of SA at the concentration of 300 μM yielded taxol 625.47 μg L-1, 45- fold higher than that of the control.
Kamalraj Subban, Ramesh Subramani, Vishnu Priya Madambakkam Srinivasan, Muthumary Johnpaul, Jayabaskaran Chelliah   +4 more
doaj   +2 more sources

Transcriptome and Metabolome Analyses of Taxus chinensis var. mairei Tissues Provide New Insights into the Regulation of Paclitaxel Biosynthesis [PDF]

Plants
Taxus is the natural source of the anticancer drug paclitaxel. Although significant progress has been made in elucidating the biosynthetic pathway of paclitaxel, its tissue-specific accumulation and associated regulatory networks in Taxus remains unclear.
Luyuan Jiang, Yanyan Li, Xiaoyang Jiang, Fenjuan Shao, Wenli Wu, Fan Xu, Iain Wilson, Angela Hoffman, Yanfang Yang, Deyou Qiu   +9 more
doaj   +2 more sources

Use of endophytic fungi in the Taxol anticancer drug production [PDF]

Biotecnología Vegetal, 2014
Taxol is a drug used in the chemotherapy of breast, lung, ovarian, prostate, liver cancers, and in the treatment of rheumatoid arthritis. Taxol is obtained from Taxus spp. trees. It is found in low concentrations in the bark, needles and roots.
Hebert Jair Barrales-Cureño, Raqueline de la Rosa Montoya   +1 more
doaj   +1 more source

Transcriptome-wide identification and screening of WRKY factors involved in the regulation of taxol biosynthesis in Taxus chinensis. [PDF]

Sci Rep, 2018
WRKY, a plant-specific transcription factor family, plays important roles in pathogen defense, abiotic cues, phytohormone signaling, and regulation of plant secondary metabolism. However, little is known about the roles, functions, and mechanisms of WRKY
Zhang M, Chen Y, Nie L, Jin X, Liao W, Zhao S, Fu C, Yu L.   +7 more
europepmc   +2 more sources