Results 51 to 60 of about 244,215 (151)

Natural Product‐Induced Ferroptosis to Overcome Therapy Resistance in Aggressive Cancers

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
Natural products trigger ferroptosis through iron overload, glutathione depletion, glutathione peroxidase 4 inhibition, and reactive oxygen species accumulation, selectively targeting aggressive, and drug‐resistant cancers. Polyphenols, alkaloids and terpenoids emerge as promising multi‐target agents to overcome therapy resistance and improve future ...
Giorgio Antoniolli
wiley   +1 more source

Cloning, Heterologous Expression, and Characterization of a Phenylalanine Aminomutase Involved in Taxol Biosynthesis [PDF]

Journal of Biological Chemistry, 2004
Biosynthesis of the N-benzoyl phenylisoserinoyl side chain of the anticancer drug Taxol starts with the conversion of 2S-alpha-phenylalanine to 3R-beta-phenylalanine by phenylalanine aminomutase (PAM). A gene cloning approach was based on the assumption that PAM would resemble the well known plant enzyme phenylalanine ammonia lyase.
Kevin D, Walker, Karin, Klettke, Takumi, Akiyama, Rodney, Croteau   +3 more
openaire   +2 more sources

Improved production of Taxol® precursors in S. cerevisiae using combinatorial in silico design and metabolic engineering

Microbial Cell Factories, 2023
Background Integrated metabolic engineering approaches that combine system and synthetic biology tools enable the efficient design of microbial cell factories for synthesizing high-value products. In this study, we utilized in silico design algorithms on
Koray Malcı, Rodrigo Santibáñez, Nestor Jonguitud-Borrego, Jorge H. Santoyo-Garcia, Eduard J. Kerkhoven, Leonardo Rios-Solis   +5 more
doaj   +1 more source

The Epigenetic Regulation in Plant Specialized Metabolism: DNA Methylation Limits Paclitaxel in vitro Biotechnological Production

Frontiers in Plant Science, 2022
Environmental conditions are key factors in the modulation of the epigenetic mechanisms regulating gene expression in plants. Specifically, the maintenance of cell cultures in optimal in vitro conditions alters methylation patterns and, consequently ...
Ainoa Escrich, Rosa M. Cusido, Mercedes Bonfill, Javier Palazon, Raul Sanchez-Muñoz, Elisabeth Moyano   +5 more
doaj   +1 more source

Convolvulus althaeoides as a Potential Natural Source in Cancer Prophylaxis and Treatment: LC‐ESI‐MS/MS, GC‐MS, In Vitro, and In Silico Investigations

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
n‐hexane and EtOAc fractions of Convolvulus althaeoides aerial parts have potent cytotoxicity, significant antioxidant, and moderate anti‐inflammatory effects. These activities emphasize the potential role of this plant in cancer prophylaxis and treatment.
Ahmed R. Hassan, Shaimaa Negm El‐Dein, Amany M. Korkor, Nourelhoda F. Hassan, Ahmed A. M. A. Selim   +4 more
wiley   +1 more source

Selection and validation of reference genes for quantitative gene expression normalization in Taxus spp.

Scientific Reports, 2020
Quantitative real-time PCR (qRT-PCR) is commonly used to measure gene expression to further explore gene function, while suitable reference genes must be stably expressed under different experimental conditions to obtain accurate and reproducible data ...
Kaikai Zhang, Wei Fan, Duanfen Chen, Luyuan Jiang, Yunfeng Li, Zhiwang Yao, Yanfang Yang, Deyou Qiu   +7 more
doaj   +1 more source

Exploiting the Biosynthetic Potency of Taxol from Fungal Endophytes of Conifers Plants; Genome Mining and Metabolic Manipulation

Molecules, 2020
Endophytic fungi have been considered as a repertoire for bioactive secondary metabolites with potential application in medicine, agriculture and food industry.
Ashraf S.A. El-Sayed, Manal T. El-Sayed, Amgad M. Rady, Nabila Zein, Gamal Enan, Ahmed Shindia, Sara El-Hefnawy, Mahmoud Sitohy, Basel Sitohy   +8 more
doaj   +1 more source

GhTTLL12 Coordinates With Transcriptional Regulators GhMML3 and GhMYB86 to Orchestrate Cotton Fibre Development Through Modulating Microtubule Dynamics

Plant Biotechnology Journal, Volume 24, Issue 10, Page 5320-5339, October 2026.
ABSTRACT Microtubules (MTs) are crucial for cell division, growth, development and morphogenesis in plants. Cotton fibres are single‐celled trichomes that originate from the epidermal cells of the ovule, making them an excellent model for studying plant cell differentiation and rapid elongation.
Xiaowei Ma, Xubinmiao Huang, Jinfang Li, Ting Zhao, Zhenfeng Ling, Shengcai Huang, Zesheng Rui, Yue Shi, Yulin Xing, Lei Sun, Mengting Wang, Haoxi Song, Rui Chen, Zequan Chen, Lei Shao, Nangan Sun, Junduo Wang, Juyun Zheng, Lei Fang   +18 more
wiley   +1 more source

ChemInform Abstract: Biosynthesis of Taxol

ChemInform, 1998
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
openaire   +2 more sources

Evolution‐Inspired Engineering of Diterpene Biosynthesis via Chloroplast Genome Modification

Plant Biotechnology Journal, Volume 24, Issue 10, Page 5510-5525, October 2026.
ABSTRACT Terpenes constitute the largest and most structurally diverse class of plant secondary metabolites, with critical roles in plant‐environment interactions and broad industrial applications. Although nuclear genome engineering of terpene pathways has been extensively explored, chloroplast genome engineering remains largely undeveloped, with most
Alessandro Occhialini, Xinlu Chen, Samantha A. Miller, Mohammad Majdi, Ivette A. Fuentes Quispe, Gabriella King, Feng Chen   +6 more
wiley   +1 more source