Results 51 to 60 of about 3,967 (187)

Elimination of enzymes catalysis compartmentalization enhancing taxadiene production in Saccharomyces cerevisiae

Frontiers in Bioengineering and Biotechnology, 2023
Taxadiene is an important precursor in taxol biosynthesis pathway, but its biosynthesis in eukaryotic cell factories is limited, which seriously hinders the biosynthesis of taxol.
Chenglong Zhang, Wang Chen, Tianyu Dong, Ying Wang, Mingdong Yao, Wenhai Xiao, Wenhai Xiao, Bingzhi Li   +7 more
doaj   +1 more source

Asymmetric Total Synthesis of Taxol [PDF]

, 2021
Taxol is one of the most famous natural diterpenoids and an important anticancer medicine. Taxol represents a formidable synthetic challenge and has prompted significant interest from the synthetic community.
Ya-Jian Hu, Ya-Jian Hu (4377772), Long Min, Chuang-Chuang Li, Long Min (3838219), Xin-Feng Wang, Chen-Chen Gu (9116273), Chen-Chen Gu, Chuang-Chuang Li (1264557), Xin-Feng Wang (486604)   +9 more
core   +1 more source

Recent Advances in Metabolic Engineering, Protein Engineering, and Transcriptome-Guided Insights Toward Synthetic Production of Taxol

Frontiers in Bioengineering and Biotechnology, 2021
The diterpenoid paclitaxel (Taxol®) is a blockbuster anticancer agent that was originally isolated from the Pacific yew (Taxus brevifolia) five decades ago.
Ishmael Mutanda, Jianhua Li, Fanglin Xu, Fanglin Xu, Fanglin Xu, Yong Wang   +5 more
doaj   +1 more source

Purification and Biochemical Characterization of Taxadiene Synthase from Bacillus koreensis and Stenotrophomonas maltophilia

Scientia Pharmaceutica, 2021
Taxadiene synthase (TDS) is the rate-limiting enzyme of Taxol biosynthesis that cyclizes the geranylgeranyl pyrophosphate into taxadiene. Attenuating Taxol productivity by fungi is the main challenge impeding its industrial application; it is possible ...
Ashraf S. A. El-Sayed, Maher Fathalla, Ahmed A. Shindia, Amgad M. Rady, Ashraf F. El-Baz, Yara Morsy, Basel Sitohy, Mahmoud Sitohy   +7 more
doaj   +1 more source

Fig. 6 in Sites of biosynthesis and storage of Taxol in Taxus media (Rehder) plants: Mechanism of accumulation [PDF]

, 2020
Fig. 6. In situ immuno-labelling of TS enzyme and Taxol in Taxus stem transverse sections. (A) Control stem section received no primary Abs compared to (B) a section that received anti-TS Ab and (C) a section that received anti-Taxol Ab.Published as part
Raizada, Manish N., Soliman, Sameh S.M.
core   +1 more source

Transcriptional profile of Taxus chinensis cells in response to methyl jasmonate

BMC Genomics, 2012
Background Methyl jasmonate (MeJA) has been successfully used as an effective elicitor to enhance production of taxol and other taxanes in cultured Taxus cells. However the mechanism of MeJA-mediated taxane biosynthesis remains unclear.
Li Shu-tao, Zhang Peng, Zhang Meng, Fu Chun-hua, Zhao Chun-fang, Dong Yan-shan, Guo An-yuan, Yu Long-jiang   +7 more
doaj   +1 more source

Endophytic Fungi: Key Insights, Emerging Prospects, and Challenges in Natural Product Drug Discovery

Microorganisms, 2022
Plant-associated endophytes define an important symbiotic association in nature and are established bio-reservoirs of plant-derived natural products. Endophytes colonize the internal tissues of a plant without causing any disease symptoms or apparent ...
Pragya Tiwari, Hanhong Bae
doaj   +1 more source

Review - Taxol synthesis [PDF]

, 2006
Being a complex diterpenoid, the potent anticancer drug, Taxol, requires complicated steps for its biosynthesis. In the present article, recent advances on Taxol biosynthesis pathway are reviewed, including many recently reported genes that regulate ...
K. X. Tang, H. B. Jin, B. H. Guo, G. Y. Kai   +3 more
core   +2 more sources

Transcriptome Assembly and Systematic Identification of Novel Cytochrome P450s in Taxus chinensis

Frontiers in Plant Science, 2017
Taxus spp. is a highly valuable medicinal plant with multiple pharmacological effects on various cancers. Cytochrome P450s (CYP450s) play important roles in the biosynthesis of active compounds in Taxus spp., such as the famous diterpenoid, Taxol ...
Weifang Liao, Shengying Zhao, Meng Zhang, Kaige Dong, Ying Chen, Chunhua Fu, Chunhua Fu, Longjiang Yu, Longjiang Yu   +8 more
doaj   +1 more source

On the Discorhabdins Leading to the Aleutianamine Ring System: A One‐Step in Situ Transformation Characterized Through Computational and Experimental Studies and Its Implications on Biosynthesis, Synthesis, and Pharmacology

Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.
The thiocarbenium ion rearrangement of 3‐dihydrodisorhabdin B greatly increases the recovery of aleutianamine from Latrunculia spp., a pyrroloiminoquinone natural product with potent activity against drug‐resistant cancers, collected from the deep‐ocean along the Aleutian Islands.
Cody F. Dickinson, Abhay Potluri, Alison M. Bland, Samuel M. Flipse, George S. Hanna, Ryan T. Wagner, Keith D. Robertson, Thai H. Ho, Daniel J. Sprague, Gerald R. Hoff, Robert P. Stone, Marcus A. Tius, Dean J. Tantillo, Mark T. Hamann   +13 more
wiley   +2 more sources