Results 71 to 80 of about 3,967 (187)
eFood, Volume 7, Issue 4, August 2026.Physapubescin B may interfere with multiple cancer‐associated signaling pathways by inhibiting Ras/Raf/mitogen‐activated protein kinase kinase/extracellular signal‐regulated kinase (Ras/Raf/MEK/ERK) signaling and vascular endothelial growth factor (VEGF)‐dependent angiogenesis.
Wojciech Koch +11 more
wiley +1 more source
Microbial Cell Factories, 2023 Background Integrated metabolic engineering approaches that combine system and synthetic biology tools enable the efficient design of microbial cell factories for synthesizing high-value products. In this study, we utilized in silico design algorithms on
Koray Malcı +5 more
doaj +1 more source
Frontiers in Plant Science, 2022 Environmental conditions are key factors in the modulation of the epigenetic mechanisms regulating gene expression in plants. Specifically, the maintenance of cell cultures in optimal in vitro conditions alters methylation patterns and, consequently ...
Ainoa Escrich +5 more
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, Volume 20, Issue 7, Page 1667-1693, July 2026.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Biotransormations with plant coenzyme A-dependent acyltransferases [PDF]
, 2008 The acylation of plant natural products is widely observed in nature and this modification often confers novel bioactivities. In nature, each of these acylations is selectively catalysed by a coenzyme A-dependent acyltransferase and biotransformations ...
Cunningham, Oliver David
core
Scientific Reports, 2020 Quantitative real-time PCR (qRT-PCR) is commonly used to measure gene expression to further explore gene function, while suitable reference genes must be stably expressed under different experimental conditions to obtain accurate and reproducible data ...
Kaikai Zhang +7 more
doaj +1 more source
Molecules, 2020 Endophytic fungi have been considered as a repertoire for bioactive secondary metabolites with potential application in medicine, agriculture and food industry.
Ashraf S.A. El-Sayed +8 more
doaj +1 more source
Taxol biosynthesis: Taxane 13α-hydroxylase is a cytochrome P450-dependent monooxygenase [PDF]
Proceedings of the National Academy of Sciences, 2001 A central feature in the biosynthesis of Taxol is oxygenation at multiple positions of the taxane core structure, reactions that are considered to be mediated by cytochrome P450-dependent monooxygenases. A PCR-based differential display-cloning approach, usingTaxus(yew) cells induced for Taxol production, yielded a family of related cytochrome P450 ...
S, Jennewein +3 more
openaire +2 more sources
Vacuolization as a Novel Approach to Cancer Therapy
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.This review discusses the novel strategy of inducing vacuole formation in cancer cells using small molecules, that induce nonapoptotic cell death mechanisms, such as paraptosis, oncosis, autophagy, and methuosis, and its potential in overcoming resistance to apoptosis‐based cancer therapies.
Mariah Pasternak +9 more
wiley +1 more source
Homoisoflavonoids—From Natural Specificity and Biosynthesis to Precision Health‐Promoting Mechanisms
Food Frontiers, Volume 7, Issue 3, May 2026.Homoisoflavonoids are rare flavonoids with a unique bi‐aromatic oxygen‐heterocyclic structure. This review synthesizes their structure–activity relationships in anti‐inflammatory, hypoglycemic, and anticancer contexts. By highlighting their specific natural distribution and outlining biosynthetic pathways, it provides a conceptual framework and ...
Jing Zhang +4 more
wiley +1 more source