Results 91 to 100 of about 3,967 (187)
ChemistryOpen, Volume 15, Issue 4, April 2026.Natural products derived from plants, animals, fungi, bacteria, and minerals contain diverse bioactive classes such as alkaloids, flavonoids, terpenoids, saponins, tannins, and phenolics. These natural products work through different mechanisms, including ROS inhibition, NF‐κB suppression, and cytokine regulation, and exhibit wide applications across ...
Sajid Ali +4 more
wiley +1 more source
Deep sequencing reveals transcriptome re-programming of Taxus × media cells to the elicitation with methyl jasmonate. [PDF]
PLoS ONE, 2013 Plant cell culture represents an alternative source for producing high-value secondary metabolites including paclitaxel (Taxol®), which is mainly produced in Taxus and has been widely used in cancer chemotherapy.
Guiling Sun +8 more
doaj +1 more source
Studies on Taxol biosynthesis: preparation of taxadiene-diol and triol derivatives by deoxygenation of taxusin [PDF]
Tetrahedron, 2008 The putative taxol biosynthesis metabolites, taxa-4(20),11(12)-diene-5α, 13α -diol (7), taxa-4(20),11(12)-diene-5α, 9α, 13α-triol (9), and taxa-4(20),11(12)-diene-5α, 10β, 13α-triol (10), have been prepared by Barton deoxygenation of the C-9 and C10-hydroxyl groups of protected derivatives of taxusin, a major taxoid metabolite isolated from Yew heart ...
Hui, Li +3 more
openaire +2 more sources
Molecular Pharming: Advances, Applications, and Future Prospects in Biotechnology and Medicine
Engineering in Life Sciences, Volume 26, Issue 3, March 2026.ABSTRACT Genetically engineered plants incorporate the use of a novel bioreactor known as molecular pharming, which has a transformative view on the pharmaceutical industry. The technique enables mass production, at a low cost, and reproducibly of a large number of different protein‐based drugs, vaccines, and industrial enzymes. This review‐based study
Md. Hridoy Ahmed +13 more
wiley +1 more source
The Synthesis of [16,17-^14C]Geranylgeranyl Pyrophosphate as a Probe for The Biosynthesis of Taxol [PDF]
, 1992 Taxol, a highly functionalized and complex diterpene belonging to the taxane group, possesses strong antitumor activity against various cancers, especially in cases of advanced ovarian and breast cancers.
Huynh, Tram
core
Rethinking production of Taxol (R) (paclitaxel) using endophyte biotechnology [PDF]
, 2014 Taxol (R) (generic name paclitaxel) represents one of the most clinically valuable natural products known to mankind in the recent past. More than two decades have elapsed since the notable discovery of the first Taxol (R) producing endophytic fungus ...
Singh, Satpal +2 more
core +1 more source
The role of cytokines in ovarian cancer drug resistance
International Journal of Cancer, Volume 158, Issue 4, Page 821-834, 15 February 2026.Abstract Ovarian cancer is the leading cause of death among women diagnosed with female reproductive system cancers. While significant advances have been made in treating various types of cancer, progress in ovarian cancer treatment over the past 20 years has been minimal, and the treatment course of ovarian cancer is not linear. Although many patients
Lu Wang +7 more
wiley +1 more source
Enhancement of taxol production by in situ recovery of product [PDF]
, 1998 The effects of addition of adsorbents on the production of taxol and taxane compounds were investigated in Taxus cuspidata cell culture. As a suitable adsorbent, the non-ionic exchange resin XAD-4, among several adsorbents tested, showed maximum ...
J H Lee, J O Hyun, Y J Yoo, I C Kwon
core +1 more source
Natural Products in Cancer Prevention and Therapy: Current Challenges and Future Directions
MedComm, Volume 7, Issue 2, February 2026.Natural products play a pivotal role in cancer therapy. They induce cancer cell death by reprogramming four metabolic pathways while precisely targeting the tumor microenvironment and immune cells. These compounds not only leverage novel delivery systems for innovative applications but also demonstrate unique therapeutic efficacy across clinical stages:
Ruimiao Qian +8 more
wiley +1 more source
Metabolic Control Analysis of Taxol Biosynthesis:An in Silico Approach to Improving Productio [PDF]
, 2006 Objective: To gain further insight into taxol biosynthesis relevant to improving production of this anticancer drug. Methods: A kinetic model representing the pathway for biosynthesis of taxol has been developed.
杨胜利 +6 more
core