Results 91 to 100 of about 244,215 (151)

Downstream reactions and engineering in the microbially reconstituted pathway for Taxol [PDF]

, 2016
Taxol (a trademarked product of Bristol-Myers Squibb) is a complex isoprenoid natural product which has displayed potent anticancer activity. Originally isolated from the Pacific yew tree (Taxus brevifolia), Taxol has been mass-produced through processes
Pfeifer, Blaine A., Stephanopoulos, Gregory, Jiang, Ming   +2 more
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An investigation of the role of the ErbB receptor family in chemotherapeutic drug resistance and invasion in human breast cancer [PDF]

, 2002
The purpose of the work described in this thesis was to investigate the effects of upregulation of c-erbB-2 by cDNA transfection and the downregulation by ribozyme transfection on chemotherapeutic drug sensitivity, in vitro invasion, and expression of a ...
Glynn, Sharon
core   +2 more sources

Transcriptome and Metabolome Analyses of Taxus chinensis var. mairei Tissues Provide New Insights into the Regulation of Paclitaxel Biosynthesis

Plants
Taxus is the natural source of the anticancer drug paclitaxel. Although significant progress has been made in elucidating the biosynthetic pathway of paclitaxel, its tissue-specific accumulation and associated regulatory networks in Taxus remains unclear.
Luyuan Jiang, Yanyan Li, Xiaoyang Jiang, Fenjuan Shao, Wenli Wu, Fan Xu, Iain Wilson, Angela Hoffman, Yanfang Yang, Deyou Qiu   +9 more
doaj   +1 more source

Analysis genome of Pseudotaxus chienii reveals insights into the origin and evolution of taxane biosynthesis

Nature Communications
As a sister genus to Taxus, Pseudotaxus holds significant importance for studying the origin and evolution of the taxane biosynthesis pathway. However, the reference genome of Pseudotaxus chienii is yet unavailable.
Mingshuang Wang, Ruoyun Ma, Zijin Fang, Lingxiao Zhang, Yibo Zhang, Mengyin Zheng, Enhui Bai, Wanting Lin, Yanyan Pei, Yue Zang, Huijie Ma, Shangguo Feng, Xiaori Zhan, Chunna Yu, Shuling Wang, Huizhong Wang, Chenliang Yu, Chenjia Shen   +17 more
doaj   +1 more source

Genome-Wide Analysis of bZIP Transcription Factors and Expression Patterns in Response to Shading Treatment in Taxus yunnanensis

Current Issues in Molecular Biology
Basic leucine zipper (bZIP) transcription factors are widely involved in plant growth, development, environmental adaptation, and secondary metabolism. However, the bZIP gene family in Taxus yunnanensis has not been systematically characterized, and its ...
Jiangtao Fan, Pengpeng Gong, Yujia Liu, Mengke Dou, Qing Li, Qiuhong Hu, Yong Wang, Gang Wang, Xiong Huang   +8 more
doaj   +1 more source

High Quality RNA Isolation from Leaf, Shell, Root Tissues and Callus of Hazelnut (Corylus avellana L.) [PDF]

Journal of Nuts, 2017
Extraction of high quality RNA is a critical step in molecular genetics studies. Hazelnut is one of the most important nuts plants in the world. The presence of the taxol and other taxanes in hazelnut plant necessitates explaining their biosynthesis ...
Hossein Khosravi, Ali Deljou, Sajad Rashidi Monfared   +2 more
doaj  

Studies on Taxol Biosynthesis. Preparation of Taxa-4(20),11(12)-dien-5α-acetoxy-10β-ol by Deoxygenation of a Taxadiene Tetraacetate Obtained from Japanese Yew

, 2016
Taxa-4(20),11(12)-dien-5α-acetoxy-10β-ol 6 has been identified as an early stage intermediate involved in the biosynthesis of taxol (Paclitaxel). This compound has been efficiently prepared by Barton deoxygenation of the C-2- and C-14-hydroxyl groups on ...
Christopher D. Rithner (2037814), Rodney Croteau (2680519), Tohru Horiguchi (3032676), Robert M. Williams (1333935)   +3 more
core   +1 more source

Oxetane Ring Formation in Taxol Biosynthesis Is Catalyzed by a Bifunctional Cytochrome P450 Enzyme

Taxol is a potent drug used in various cancer treatments. Its complex structure has prompted extensive research into its biosynthesis. However, certain critical steps, such as the formation of the oxetane ring, which is essential for its activity, have ...
Dan Staerk (135389), Yong Zhao (84950), Thomas G. Pomorski (17693691), Irini Pateraki (746519), Feiyan Liang (17693682), Aggeliki Andeadelli (17693688), Sotirios C. Kampranis (564823), Yuman Xie (17693685), Yao-Tao Duan (16913065), Antonios M. Makris (746525)   +9 more
core   +2 more sources

Enhancing taxane production in Corylus avellana L. cell cultures through elicitation using molybdenum oxide and iron oxide nanoparticles

Industrial Crops and Products
Taxanes are widely employed in cancer therapy for the treatment of various malignancies. Recent studies have shown that cell cultures from Corylus avellana L. could be a promising source for producing taxanes commercially.
Roghayyeh Hazrati, Nasser Zare, Rasool Asghari-Zakaria, Parisa Sheikhzadeh, Mahipal S. Shekhawat, Rupesh Kumar Singh   +5 more
doaj   +1 more source

Metabolic Control Analysis of Taxol Biosynthesis:An in Silico Approach to Improving Productio

, 2006
Objective: To gain further insight into taxol biosynthesis relevant to improving production of this anticancer drug. Methods: A kinetic model representing the pathway for biosynthesis of taxol has been developed.
杨胜利, 蒋达, 马晓华, 杨凌, 李艳红, 李燕, 王永华   +6 more
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