Results 101 to 110 of about 244,215 (151)

Enhancing the biosynthesis of taxadien-5α-yl-acetate in Escherichia coli by combinatorial metabolic engineering approaches

Bioresources and Bioprocessing
Biosynthesis of paclitaxel (Taxol™) is a hot topic with extensive and durable interests for decades. However, it is severely hindered due to the very low titers of intermediates.
Wen-Liang Xie, Mei-Fang Zhang, Zheng-Yu Huang, Man Xu, Chun-Xiu Li, Jian-He Xu   +5 more
doaj   +1 more source

FoTO1 orchestrates Taxol biosynthesis through catalytic and non-catalytic mechanisms

Abstract Taxol is a blockbuster chemotherapeutic derived from the Pacific Yew tree. Recent work in our group has identified a complete pathway to baccatin III, a key intermediate, that hinges on a novel accessory protein, Facilitator of Taxane Oxidation (FoTO1).
Chloe Wick, Anish Somani, Jack Chun-Ting Liu, Sumudu S Karunadasa, Shou-Ling Xu, Polly M. Fordyce, Conor James McClune, Elizabeth S. Sattely   +7 more
openaire   +2 more sources

Taxol Reduces Cytosolic E-Cadherin and Beta-Catenin Levels in Nasopharyngeal Carcinoma Cell Line Tw-039: Cross-Talk between the Microtubule- and Actin-Based Cytoskeletons

, 2008
Taxol affects microtubule dynamics by promoting microtubule assembly. To obtain a better insight into possible cross- talk between the microtubule- and actin-based cytoskeletons, we studied the short-term effects of Taxol treatment on the expression of ...
LOU, PEI-JEN;CHEN, WEN-PIN;LIN, CHIN- TARNG;CHEN, HUI-CHIN;WU, JIAHN-CHUN, 婁培人;陳文彬;林欽塘;陳慧瑾;吳建春   +1 more
core  

1-phenyl-2-decanoylamino-3-morpholino-1-propanol chemosensitizes neuroblastoma cells for taxol and vincristine

, 2000
In this study, we show that an inhibitor of glycosphingolipid biosynthesis, D,L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP), increases the chemosensitivity of neuroblastoma tumor cells for Taxol and vincristine.
Vellenga, E, Sietsma, H, Ausema, B, Veldman, Robert, Kamps, W, Kok, JW, Nijhof, W   +6 more
core   +1 more source

Metabolic engineering for the optimal production of Taxol (Paclitaxel) - an efficient anticancer drug (focusing on upstream pathways for isoprenoid accumulation).

, 2013
Taxol is one of the most important and active chemotherapeutic agents for clinical treatment of cancers (including ovarian, breast bladder, prostate, and lung cancers), since taxol is an anti-proliferative agent that inhibits cancer cell division ...
Ng, James Shizhao.
core  

TAKSOL VE TÜREVLERİNİN BİYOSENTEZİ : THE BIOSYNTHESIS OF TAXOL AND DERIVATIVES

Ankara Universitesi Eczacilik Fakultesi Dergisi, 1999
Nurgün ERDEMOĞLU, Bilge ŞENER
openaire   +1 more source

Recent Advances in the Biosynthesis and Biotechnological Production of Taxol

Engineering
Yuxun Zhu, Feiyan Liang, Pengpei Chai, Sotirios C. Kampranis, Yong Zhao   +4 more
openaire   +1 more source

High-yield biosynthesis of taxol precursors in engineered Escherichia coli [PDF]

Science-Business eXchange, 2010
openaire   +1 more source

Abstract 2282 Chemistry and Biology of Taxol Biosynthesis

Journal of Biological Chemistry
openaire   +1 more source

Insights Into Taxol® Biosynthesis by Endophytic Fungi [PDF]

Applied Microbiology and Biotechnology, 2023
Abstract There have been two hundred reports that endophytic fungi produce Taxol®, but its production yield is often rather low. Although considerable efforts have been made to increase Taxol/taxanes production in fungi by manipulating cocultures, mutagenesis, genome shuffles, and gene overexpression, little is known ...
Frank Kempken, Kamalraj Subban
exaly   +5 more sources