Results 101 to 110 of about 3,967 (187)
Hazel (Corylus avellana L.) as a New Source of Taxol and Taxanes
Journal of Medicinal Plants, 2012 Taxol is used to treatment of variety cancers including ovarian, breast, lung, head and neck carcinomas and the AIDS-related Karposi’s carcinoma, and was originally obtained from bark of taxus brevifolia.
A Qaderi +6 more
doaj
Plant Biotechnology Journal, Volume 24, Issue 1, Page 31-43, January 2026.Summary In plant molecular farming, recombinant products include traditional protein targets, such as antibodies, antigens, and enzymes, but also increasingly refers to high‐value peptides, and small molecules produced by heterologous enzymatic pathways.
Maxim D. Harding, Frank Sainsbury
wiley +1 more source
BioMed Research International, Volume 2026, Issue 1, 2026.Introduction Cancer is a versatile disease with a high rate of relapse and mortality. Despite the presence of various treatment modalities, there is a serious need for the development of its management. Phytochemicals, which are abundant in nature, can be turned into novel medications for these types of diseases by optimizing their functions and ...
Mithila Kulkarni +5 more
wiley +1 more source
Journal of Microbiology and Biotechnology, 2019 The fungal products dibenzodioxocinones promise a novel class of inhibitors against cholesterol ester transfer protein (CEPT). Knowledge as to their biosynthesis is scarce. In this report, we characterized four more dibenzodioxocinones, which along with a previously described member pestalotiollide B, delimit the dominant spectrum of secondary ...
Yanjie, Liu +9 more
openaire +3 more sources
Molecular Oncology, Volume 19, Issue 12, Page 3665-3684, December 2025.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Studies on the total synthesis of putative intermediates in the biosynthesis of taxol
, 2003 The exploration of several strategies for the synthesis of taxoids useful for studying the biosynthesis of taxol is presented. The approaches described include attempts to access the taxane carbon skeleton through closure of the B-ring across the C-2 – C-3 bond or the C-10 – C-11 bond, as well as attempts to form the A- and B-rings using an ...
Lenger, Steven Robert, author +1 more
openaire +1 more source
Advanced Science, Volume 12, Issue 45, December 4, 2025.The underexplored bacterial genus Aquimarina harbors a large biosynthetic potential for discovering new antibiotics. Here, the authors identify a pair of linear or cyclic bifunctional cationic lipopeptide antibiotics, aquicidine L and C4, inspired by the aquicidine gene cluster from Aquimarina.
Lei Li, Yiwen Zhou, Yuzhu Wu
wiley +1 more source
Oxetane Ring Formation in Taxol Biosynthesis Is Catalyzed by a Bifunctional Cytochrome P450 Enzyme [PDF]
Taxol is a potent drug used in various cancer treatments. Its complex structure has prompted extensive research into its biosynthesis. However, certain critical steps, such as the formation of the oxetane ring, which is essential for its activity, have ...
Dan Staerk (135389) +9 more
core +1 more source
TcJAV3-TcWRKY26 Cascade Is a Missing Link in the Jasmonate-Activated Expression of Taxol Biosynthesis Gene DBAT in Taxus chinensis. [PDF]
Int J Mol Sci, 2022 Chen L +7 more
europepmc +1 more source
Downstream reactions and engineering in the microbially reconstituted pathway for Taxol [PDF]
, 2016 Taxol (a trademarked product of Bristol-Myers Squibb) is a complex isoprenoid natural product which has displayed potent anticancer activity. Originally isolated from the Pacific yew tree (Taxus brevifolia), Taxol has been mass-produced through processes
Pfeifer, Blaine A. +2 more
core +1 more source