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Getting to the Bottom of Taxol Biosynthesis by Fungi [PDF]

Fungal Diversity, 2013
Taxol (paclitaxel) is a highly-oxygenated diterpenoid natural product first isolated from the pacific yew tree (Taxus brevifolia). It is one of the most widely used anticancer drugs. Soon after the discovery of its unique mode of action and the resulting high demand, an extensive search was initiated for alternative sources to replace the slow-growing ...
Stefan Jennewein
exaly   +3 more sources

Taxol Biosynthesis: An Update [PDF]

Planta Medica, 1997
The novel diterpenoid taxol (paclitaxel) is now well-established as a potent chemotherapeutic agent. Total synthesis of the drug is not commercially feasible and, in the foreseeable future, the supply of taxol and its synthetically useful progenitors must rely on biological methods of production.
Rodney Croteau, R Croteau
exaly   +3 more sources

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Biosynthesis of Taxol

Angewandte Chemie International Edition in English, 1997
Jurgen T. Rohr
exaly   +2 more sources

Cloning and Sequencing of Hydroxylase Genes Involved in Taxol Biosynthesis

Zeitschrift Fur Naturforschung - Section C Journal of Biosciences, 2004
Abstract Two full-length cDNAs (TCH1 and TCH2) were obtained from a cDNA library of Taxus chinensis mainly by the single specific-primer PCR (SSP-PCR) method. Compared with other reported enzymes from Taxus species, the deduced amino acid sequences of TCH1 and TCH2 exhibit significant homologies to hydroxylases that are involved in ...
Ping Zhu, Jun Tu
exaly   +3 more sources

Taxol: biosynthesis, molecular genetics, and biotechnological applications

Applied Microbiology and Biotechnology, 2001
Over the past decade, Taxol and its closely related structural analogue Taxotere have emerged as very important antitumor agents. Their widespread use in the treatment of a variety of cancer types, their likely approval for the treatment of additional forms of cancer, and their use at earlier stages of intervention will lead to increased demand for ...
S, Jennewein, R, Croteau
openaire   +2 more sources

Synthetic Biology for Taxol Biosynthesis and Sustainable Production

Trends in Biotechnology
Incomplete understanding of the biosynthetic pathway of the anticancer compound Taxol hinders its production by metabolic engineering. Recent reports by Jiang et al. and other groups now describe the missing steps in Taxol biosynthesis, notably including oxetane ring formation.
Jiaoqi Gao, Yongjin J Zhou, Linfeng Xie
exaly   +3 more sources

Rewiring cellular metabolism for heterologous biosynthesis of Taxol

Natural Product Research, 2019
Taxol is one of the anticancer drugs synthesized naturally in the evergreen Taxus brevifolia forest tree belonging to the yew family (Taxaceae) growing on the Pacific. There are reportedly evidence for treating ovarian, breast and lung cancers through this drug given its unique structural and functional features.
Amirhossein Nazhand, Alessandra Durazzo, Massimo Lucarini, Maria Alessandra Mobilia, Besma Omri, Antonello Santini   +5 more
openaire   +3 more sources

Specificity of the N-Benzoyl Transferase Responsible for the Last Step of Taxol Biosynthesis [PDF]

Archives of Biochemistry and Biophysics, 2008
The last few steps in the biosynthesis of the anticancer drug Taxol in yew (Taxus) species are thought to involve the attachment of beta-phenylalanine to the C13-O-position of the advanced taxane diterpenoid intermediate baccatin III to yield N-debenzoyl-2'-deoxytaxol, followed by hydroxylation on the side chain at the C2'-position to afford N ...
Rodney Croteau, Robert M Coates
exaly   +3 more sources

ChemInform Abstract: Taxol Biosynthesis: An Update

ChemInform, 1997
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
M. HEZARI, R. CROTEAU
openaire   +1 more source

Towards the biosynthesis of an alternative to Taxol

Molecular Medicine Today, 1998
Kosan Biosciences (Burlingame, CA, USA) has received a Phase I Small Business Innovative Research Grant from the US National Cancer Institute to support their work on the biosynthetic pathway of the epothilones, a group of polyketides first isolated from the soil myxobacterium Sorangium cellulosum, as potential alternatives to the anticancer drug ...
openaire   +1 more source