Results 111 to 120 of about 3,967 (187)

A Review on Taxol Production through Biotechnological Approaches

Journal of Medicinal Plants, 2018
Taxol is a very important anticancer drug which was first isolated from Yew plant (Taxus spp.). However, Taxol supply by extraction from natural sources, has several limitations, and cannot meet current marketchr('39')s demands.
M Majidi, AR tarinejad
doaj  

Reconstitution of the Costunolide Biosynthetic Pathway in Yeast and Nicotiana benthamiana. [PDF]

, 2011
The sesquiterpene costunolide has a broad range of biological activities and is the parent compound for many other biologically active sesquiterpenes such as parthenolide.
Charnikhova, T., van der Krol, S., Verstappen, Francel W. A., Vos, R.C.H., de, Harro J. Bouwmeester, Cankar, Katarina, Krol, S., van der, Francel W. A. Verstappen, Tatsiana Charnikhova, Katarina Cankar, de Vos Ric C. H., Majdi, M., Sander van der Krol, Liu Qing, Harro J Bouwmeester, Miriam Goedbloed, Bouwmeester Harro J., Jules Beekwilder, Beekwilder, Jules, Ric C H de Vos, Qing Liu, Majdi, Mohammad, Ric C. H. de Vos, Francel W A Verstappen, Goedbloed Miriam, Charnikhova, Tatsiana, Mohammad Majdi, de Vos, R.C.H., Cankar, K., Cankar Katarina, van der Krol Sander, Liu, Q., Beekwilder Jules, Bouwmeester, Harro, Charnikhova Tatsiana, Goedbloed, M.A., Verstappen, F.W.A., van der Krol, Sander, Verstappen Francel W. A., de Vos, Ric, Goedbloed, Miriam, Bouwmeester, H.J., Beekwilder, M.J., Liu, Qing, Majdi Mohammad   +44 more
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Studies on the evolution of complex natural products biosynthetic pathways on basis of Taxol biosynthesis in plants and endophytic fungi [PDF]

, 2012
Focus of the present PhD thesis was the examination of the interesting and only poorly understood phenomenon of detection of identical natural products in distantly related organisms with regard to metabolite pathway evolution. Due to the impact of Taxol
Heinig, Uwe Herbert
core   +2 more sources

Cytochrome P450 Taxadiene 5α-Hydroxylase, a Mechanistically Unusual Monooxygenase Catalyzing the First Oxygenation Step of Taxol Biosynthesis [PDF]

, 2004
The first oxygenation step in the biosynthesis of the anticancer drug taxol in Taxus species is the cytochrome P450-mediated hydroxylation (with double bond migration) of the diterpene olefin precursor taxa-4(5),11(12)-diene to taxa-4(20),11(12)-dien-5α ...
Jennewein, Stefan, Long, Robert M., Williams, Robert M., Croteau, Rodney   +3 more
core   +1 more source

Review on taxol as the most important anticancer natural drug

Journal of Medicinal Plants, 2006
Taxol is a diterpeniod with complex structure, which is extracted frequently from the genus Taxus. At present, this drug is one of the most important anticancer natural agents with different mechanism from other similar drugs, used for remedy of ...
A Yari Khosroshahi, B Habibi Khaniani, HA Naghdibadi   +2 more
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Orthogonal assays clarify the oxidative biochemistry of Taxol P450 CYP725A4 [PDF]

, 2016
Natural product metabolic engineering potentially offers sustainable and affordable access to numerous valuable molecules. However, challenges in characterizing and assembling complex biosynthetic pathways have prevented more rapid progress in this field.
William Arnold, Bradley Walters Biggs, Parayil Kumaran Ajikumar, Courtney M. Starks (604301), William Arnold (2564164), Bradley Walters Biggs (2564161), Arnold, William, John Edward Rouck (2564155), Das, Aditi, Biggs, Bradley Walters, De Mey, Marjan, Aditi Das (7940), Chin Giaw Lim, Aditi Das, Mark O’Neil-Johnson, Starks, Courtney M, Ajikumar, Parayil Kumaran, Mark O’Neil-Johnson (604302), O'Neil-Johnson, Mark, John Edward Rouck, Lim, Chin Giaw, Rouck, John Edward, Marjan De Mey, Amogh Kambalyal (2564158), Parayil Kumaran Ajikumar (2488570), Courtney M. Starks, Marjan De Mey (32256), Kambalyal, Amogh, Amogh Kambalyal, Chin Giaw Lim (2564167)   +29 more
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Engineering cyanobacteria as a new platform for producing taxol precursors directly from carbon dioxide

Biotechnology for Biofuels and Bioproducts
Taxol serves as an efficient natural anticancer agent with extensive applications in the treatment of diverse malignancies. Although advances in synthetic biology have enabled the de novo synthesis of taxol precursors in various microbial chassis, the ...
Jialing Zhong, Yushu Wang, Zhuoyang Chen, Yaliqin Yalikun, Lin He, Tiangang Liu, Gang Ma   +6 more
doaj   +1 more source

New different origins and evolutionary processes of AP2/EREBP transcription factors in Taxus chinensis

BMC Plant Biology, 2019
Background Taxus spp. produces the anticancer drug, taxol, and hence is planted as an industrial crop in China. APETALA2/ethylene response element binding proteins (AP2/EREBPs) are the key regulators of plant development, growth, and stress responses ...
Meng Zhang, Ying Chen, Xiaofei Jin, Yuxin Cai, Yuanyuan Yuan, Chunhua Fu, Longjiang Yu   +6 more
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High Quality RNA Isolation from Leaf, Shell, Root Tissues and Callus of Hazelnut (Corylus avellana L.) [PDF]

Journal of Nuts, 2017
Extraction of high quality RNA is a critical step in molecular genetics studies. Hazelnut is one of the most important nuts plants in the world. The presence of the taxol and other taxanes in hazelnut plant necessitates explaining their biosynthesis ...
Hossein Khosravi, Ali Deljou, Sajad Rashidi Monfared   +2 more
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Enhancing taxane production in Corylus avellana L. cell cultures through elicitation using molybdenum oxide and iron oxide nanoparticles

Industrial Crops and Products
Taxanes are widely employed in cancer therapy for the treatment of various malignancies. Recent studies have shown that cell cultures from Corylus avellana L. could be a promising source for producing taxanes commercially.
Roghayyeh Hazrati, Nasser Zare, Rasool Asghari-Zakaria, Parisa Sheikhzadeh, Mahipal S. Shekhawat, Rupesh Kumar Singh   +5 more
doaj   +1 more source