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[Advances of taxol combinatorial biosynthesis].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2015Taxol is a kind of isoprenoid with strong anticancer activity. It is difficult to be obtained because of its low concentration in nature, which hinders its application in cancer treatment. Recently, biosynthesis methods for taxol production have attracted more attentions.
Jie, Li, Chunmei, Wang
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Researchers Probe Steps Of Taxol Biosynthesis
Chemical & Engineering News Archive, 1996Understanding detailed pathway could lead to improved cell culture techniques for production of potent anticancer drug Researchers are beginning to understand the detailed biosynthetic pathway by which yew plants produce the anticancer agent taxol. Their findings could lead to the development of a more efficient cell culture process for commercial ...
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Key Step In Taxol Biosynthesis Revealed
Chemical & Engineering News Archive, 2000Four research groups, working collaboratively, have determined the remarkable single-step mechanism by which the acyclic compound geranylgeranyl diphosphate (GGPP) is converted biosynthetically into the tricyclic core of Bristol-Myers Squibb's anticancer agent Taxol (paclitaxel).
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[Recent advances in the biosynthesis of Taxol].
Yao xue xue bao = Acta pharmaceutica Sinica, 2009Taxol is one of the most potent chemotherapeutic agents known, showing excellent activity against a range of cancers. In addition to anticancer, taxol has the effect of preventing graft arteriosclerosis, antiscaring formation and inhibiting angiogenesis.
Jian-qiang, Kong +3 more
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Bioorganic & Medicinal Chemistry, 2001
Taxadiene, the key intermediate of paclitaxel (Taxol) biosynthesis, has been prepared enzymatically from isopentenyl diphosphate in cell-free extracts of Escherichia coli by overexpressing genes encoding isopentenyl diphosphate isomerase, geranylgeranyl diphosphate synthase and taxadiene synthase.
Q, Huang +3 more
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Taxadiene, the key intermediate of paclitaxel (Taxol) biosynthesis, has been prepared enzymatically from isopentenyl diphosphate in cell-free extracts of Escherichia coli by overexpressing genes encoding isopentenyl diphosphate isomerase, geranylgeranyl diphosphate synthase and taxadiene synthase.
Q, Huang +3 more
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Inspired by taxol: biosynthesis and engineering of hypericin and other phytochemicals in Hypericum
PlantaInsights from paclitaxel research inspire elucidation of hypericin biosynthesis, highlighting gene identification, multi-omics integration, and biotechnological strategies enabling scalable and sustainable production of valuable Hypericum secondary metabolites.
Katarína Bruňáková +3 more
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Mechanistic possibilities for oxetane formation in the biosynthesis of Taxol’s D ring
Russian Journal of General Chemistry, 2008Three mechanistic possibilities for the formation of the oxetane (D ring) of Taxol were examined at various levels of theory [B3LYP/6-31+G(d,p), mPW1PW91/6-31+G(d,p), and MP2/6-31+G(d,p)] including one mechanism involving an unusual oxabicyclobutonium ion intermediate.
Dan Willenbring, Dean J. Tantillo
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Acting paths of elicitors on Taxol biosynthesis pathway and their synergistic effect
Biochemical Engineering Journal, 2002Many elicitors have been reported to be favorable to Taxol production in suspension cultures of Taxus cells. However, their acting paths were proved to be different, which were identified based on a quasi-steady-state transfer model. It was found that silver nitrate, ammonium citrate and methyl jasmonic acid acted on the path between Baccatin III and ...
Ying-Jin Yuan +3 more
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[Study on the effects of salicylic acid on taxol biosynthesis].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2000The influence of salicylic acid on the production of taxanes in plant cell culture was studied. Experimental results showed that addition of salicylic acid at concentration of 0.1 mg/L could enhance the production of taxol to three-fold. The concentration of 10-DAB and baccatin III was also increasing while taxol concentration increases under salicylic
Z Q, Miao, Z J, Wei, Y J, Yuan
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