Results 81 to 90 of about 244,215 (151)

The anti-cancer drug Taxol produced in endophytic fungi inhabiting Taxus media: Ecology, regulation and biosynthesis [PDF]

, 2010
Taxol is a diterpenoid anti-cancer drug isolated from the bark of ' Taxus' plants. Taxol was previously found to be biosynthesized in parallel by endophytic fungi inhabiting 'Taxus' and other plant species.
Soliman, Sameh S. M.
core  

On the Discorhabdins Leading to the Aleutianamine Ring System: A One‐Step in Situ Transformation Characterized Through Computational and Experimental Studies and Its Implications on Biosynthesis, Synthesis, and Pharmacology

Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.
The thiocarbenium ion rearrangement of 3‐dihydrodisorhabdin B greatly increases the recovery of aleutianamine from Latrunculia spp., a pyrroloiminoquinone natural product with potent activity against drug‐resistant cancers, collected from the deep‐ocean along the Aleutian Islands.
Cody F. Dickinson, Abhay Potluri, Alison M. Bland, Samuel M. Flipse, George S. Hanna, Ryan T. Wagner, Keith D. Robertson, Thai H. Ho, Daniel J. Sprague, Gerald R. Hoff, Robert P. Stone, Marcus A. Tius, Dean J. Tantillo, Mark T. Hamann   +13 more
wiley   +1 more source

A Gene Cluster for the Biosynthesis of Dibenzodioxocinons in the Endophyte Pestalotiopsis microspora, a Taxol Producer

Journal of Microbiology and Biotechnology, 2019
The fungal products dibenzodioxocinones promise a novel class of inhibitors against cholesterol ester transfer protein (CEPT). Knowledge as to their biosynthesis is scarce. In this report, we characterized four more dibenzodioxocinones, which along with a previously described member pestalotiollide B, delimit the dominant spectrum of secondary ...
Yanjie, Liu, Longfei, Chen, Qiaohong, Xie, Xi, Yu, Anqing, Duan, Yamin, Lin, Biyun, Xiang, Xiaoran, Hao, Wanwan, Chen, Xudong, Zhu   +9 more
openaire   +3 more sources

Studies on the total synthesis of putative intermediates in the biosynthesis of taxol

, 2003
The exploration of several strategies for the synthesis of taxoids useful for studying the biosynthesis of taxol is presented. The approaches described include attempts to access the taxane carbon skeleton through closure of the B-ring across the C-2 – C-3 bond or the C-10 – C-11 bond, as well as attempts to form the A- and B-rings using an ...
Lenger, Steven Robert, author, Williams, Robert M., advisor   +1 more
openaire   +1 more source

Table_1_TcMYC2a, a Basic Helix–Loop–Helix Transcription Factor, Transduces JA-Signals and Regulates Taxol Biosynthesis in Taxus chinensis.XLSX

, 2018
The multitherapeutic taxol, which can be obtained from Taxus spp., is the most widely used anticancer drug. Taxol biosynthesis is significantly regulated by jasmonate acid (JA), one of the most important endogenous hormones in land plants.
Meng Zhang (154027), Mi Wei (5432006), Chunhua Fu (483033), Ying Chen (9697), Weifang Liao (5432003), Xiaofei Jin (5432009), Longjiang Yu (422867), Shengying Zhao (5432000)   +7 more
core   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Review on taxol as the most important anticancer natural drug

Journal of Medicinal Plants, 2006
Taxol is a diterpeniod with complex structure, which is extracted frequently from the genus Taxus. At present, this drug is one of the most important anticancer natural agents with different mechanism from other similar drugs, used for remedy of ...
A Yari Khosroshahi, B Habibi Khaniani, HA Naghdibadi   +2 more
doaj  

Amesia nigricolor, a novel endophyte of Encephalartos bubalinus, exhibiting a robust taxol biosynthetic stability: chemical characterization and biological activities

Microbial Cell Factories
Diminishing the productivity of Taxol by the potential fungi with storage is the key hurdle that impedes their applications to be an industrial platform for Taxol production.
Asmaa Gamal, Ashraf S. A. El-Sayed, Eman Fikry, Nora Tawfeek, Azza M. El-Shafae, Maher M. El-Domiaty   +5 more
doaj   +1 more source

Discovery of FoTO1 and Taxol genes enables biosynthesis of baccatin III

Nature
Abstract Plants make complex and potent therapeutic molecules 1,2 , but sourcing these molecules from natural producers or through chemical synthesis is difficult, which limits their use in the clinic. A prominent example is the anti-cancer therapeutic paclitaxel (sold under
Conor James McClune, Jack Chun-Ting Liu, Chloe Wick, Ricardo De La Peña, Bernd Markus Lange, Polly M. Fordyce, Elizabeth S. Sattely   +6 more
openaire   +2 more sources

Engineering cyanobacteria as a new platform for producing taxol precursors directly from carbon dioxide

Biotechnology for Biofuels and Bioproducts
Taxol serves as an efficient natural anticancer agent with extensive applications in the treatment of diverse malignancies. Although advances in synthetic biology have enabled the de novo synthesis of taxol precursors in various microbial chassis, the ...
Jialing Zhong, Yushu Wang, Zhuoyang Chen, Yaliqin Yalikun, Lin He, Tiangang Liu, Gang Ma   +6 more
doaj   +1 more source