Results 81 to 90 of about 3,967 (187)
Journal of Genetic Engineering and Biotechnology, 2015 The most promising anti-tumor agent developed in the past three decades is Taxol. It is proven to be effective against many cancers. It is necessary to isolate pharmacologically potent endophytic microbial strains from medicinal plants with special ...
G. Roopa +9 more
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Targeted control of supporting pathways in paclitaxel biosynthesis with CRISPR-guided methylation
Frontiers in Bioengineering and Biotechnology, 2023 Introduction: Plant cell culture biomanufacturing is rapidly becoming an effective strategy for production of high-value plant natural products, such as therapeutic proteins and small molecules, vaccine adjuvants, and nutraceuticals.
Cassandra Brzycki Newton +2 more
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Studies on the biosynthesis of taxol: the taxane carbon skeleton is not of mevalonoid origin. [PDF]
Proceedings of the National Academy of Sciences, 1996 A cell culture of Taxus chinensis was established to produce the diterpene 2alpha,5alpha,10beta,14beta-tetra-acetoxy4 ++ +(20),11-taxadiene (taxuyunnanine C) in 2.6% (dry weight) yield. The incorporation of [U-13C6]glucose, [1-13C]glucose, and [1,2-13C2]acetate into this diterpene was analyzed by NMR spectroscopy.
W, Eisenreich +4 more
openaire +2 more sources
Plant Biotechnology Journal, Volume 24, Issue 5, Page 2876-2890, May 2026.ABSTRACT The synthesis and accumulation of active ingredients in medicinal plants are distributed in specific organs, tissues, and cell types, which are important for the exploitation of medicinal plants. However, the fine distribution of active ingredients is difficult to know. Here, the system of mass spectrometry imaging (MSI) integrated with single‐
HaiSheng Zeng +14 more
wiley +1 more source
Table_1_TcMYC2a, a Basic Helix–Loop–Helix Transcription Factor, Transduces JA-Signals and Regulates Taxol Biosynthesis in Taxus chinensis.XLSX [PDF]
, 2018 The multitherapeutic taxol, which can be obtained from Taxus spp., is the most widely used anticancer drug. Taxol biosynthesis is significantly regulated by jasmonate acid (JA), one of the most important endogenous hormones in land plants.
Meng Zhang (154027) +7 more
core +1 more source
Fig. 2 in Sites of biosynthesis and storage of Taxol in Taxus media (Rehder) plants: Mechanism of accumulation [PDF]
, 2020 Fig. 2. Taxol localization and storage. (A) Transverse section of a Taxus plant stem showing the location of Taxol-containing HB (red-stained droplets) within the wood and phloem in comparison to (B) close up view in the vascular bundle (VB) of a root ...
Raizada, Manish N., Soliman, Sameh S.M.
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Frontiers in Microbiology, 2013 Within a plant, there can exist an ecosystem of pathogens and endophytes, the latter described as bacteria and fungal inhabitants that thrive without causing disease to the host.
Sameh S.M. Soliman, Manish N Raizada
doaj +1 more source
IMA Fungus, 2022 The monotypic “bulbilliferous hyphomycete” genus Taxomyces was erected in 1993 for a fungal endophyte isolated from the Yew tree Taxus brevifolia and named Taxomyces andreanae. This fungus was reported to produce the plant-derived anti-cancer drug taxol.
Tian Cheng +3 more
doaj +1 more source
The Regulation and Function of Hippo/YAP Pathway in Cancer
The FASEB Journal, Volume 40, Issue 7, 15 April 2026.Hippo/YAP pathway signaling plays critical roles in the progression of multiple cancer types. This review summarizes current knowledge of Hippo/YAP pathway regulation and function in cancer. We discuss the core components of the Hippo/YAP pathway; its crosstalk with other signaling pathways; regulation by non‐coding RNAs; roles of YAP signaling in ...
Chinmoy Ghosh +3 more
wiley +1 more source
Studies on Taxol Biosynthesis. Preparation of Taxa-4(20),11(12)-dien-5α-acetoxy-10β-ol by Deoxygenation of a Taxadiene Tetraacetate Obtained from Japanese Yew [PDF]
, 2016 Taxa-4(20),11(12)-dien-5α-acetoxy-10β-ol 6 has been identified as an early stage intermediate involved in the biosynthesis of taxol (Paclitaxel). This compound has been efficiently prepared by Barton deoxygenation of the C-2- and C-14-hydroxyl groups on ...
Christopher D. Rithner (2037814) +3 more
core +1 more source