Specificity of the N-benzoyl transferase responsible for the last step of Taxol biosynthesis [PDF]
Archives of Biochemistry and Biophysics, 2008 The last few steps in the biosynthesis of the anticancer drug Taxol in yew (Taxus) species are thought to involve the attachment of beta-phenylalanine to the C13-O-position of the advanced taxane diterpenoid intermediate baccatin III to yield N-debenzoyl-2'-deoxytaxol, followed by hydroxylation on the side chain at the C2'-position to afford N ...
Rodney B Croteau, Robert M Coates
exaly +5 more sources
Omic analysis of the endangered Taxaceae species Pseudotaxus chienii revealed the differences in taxol biosynthesis pathway between Pseudotaxus and Taxus yunnanensis trees [PDF]
BMC Plant Biology, 2021 Background Taxol is an efficient anticancer drug accumulated in Taxus species. Pseudotaxus chienii is an important member of Taxaceae, however, the level of six taxoids in P. chienii is largely unknown. Results High accumulation of 10-DAB, taxol, and 7-E-
Chunna Yu +7 more
doaj +2 more sources
Taxol Biosynthesis: An Update [PDF]
Planta Medica, 1997 The novel diterpenoid taxol (paclitaxel) is now well-established as a potent chemotherapeutic agent. Total synthesis of the drug is not commercially feasible and, in the foreseeable future, the supply of taxol and its synthetically useful progenitors must rely on biological methods of production.
R Croteau, Rodney Croteau
exaly +3 more sources
Conjugation of Aspergillus flavipes Taxol with Porphyrin Increases the Anticancer Activity of Taxol and Ameliorates Its Cytotoxic Effects [PDF]
Molecules, 2020 Taxol is one of the potential anticancer drugs; however, the yield of Taxol and its cytotoxicity are common challenges. Thus, manipulating the Taxol biosynthetic pathway from endophytic fungi, in addition to chemical modification with biocompatible ...
Ashraf S. A. El-Sayed +6 more
doaj +2 more sources
Taxol biosynthesis and molecular genetics. [PDF]
Phytochem Rev, 2006 Biosynthesis of the anticancer drug Taxol in Taxus (yew) species involves 19 steps from the universal diterpenoid progenitor geranylgeranyl diphosphate derived by the plastidial methyl erythritol phosphate pathway for isoprenoid precursor supply. Following the committed cyclization to the taxane skeleton, eight cytochrome P450-mediated oxygenations ...
Croteau R +4 more
europepmc +4 more sources
Transcriptome Sequencing Reveals Regulatory Mechanisms of Taxol Synthesis in Taxus wallichiana var. Mairei [PDF]
International Journal of Genomics, 2019 Taxol is one of the most potent and effective anticancer drugs and is originally isolated from Taxus species. To investigate the specific regulatory mechanisms of taxol synthesis in Taxus wallichiana var.
Tao Wang +6 more
doaj +2 more sources
Transcriptome analysis of a taxol-producing endophytic fungus Cladosporium cladosporioides MD2 [PDF]
AMB Express, 2018 The shortage of molecular information for taxol-producing fungi has greatly impeded the understanding of fungal taxol biosynthesis mechanism. In this study, the transcriptome of one taxol-producing endophytic fungus Cladosporium cladosporioides MD2 was ...
Li-Yun Miao +9 more
doaj +2 more sources
Discovery of FoTO1 and Taxol genes enables biosynthesis of baccatin III. [PDF]
NatureAbstract Plants make complex and potent therapeutic molecules1,2, but sourcing these molecules from natural producers or through chemical synthesis is difficult, which limits their use in the clinic. A prominent example is the anti-cancer therapeutic paclitaxel (sold under the brand name Taxol), which is derived from yew trees (Taxus species ...
McClune CJ +6 more
europepmc +3 more sources
Recent Research Progress in Taxol Biosynthetic Pathway and Acylation Reactions Mediated by Taxus Acyltransferases [PDF]
Molecules, 2021 Taxol is one of the most effective anticancer drugs in the world that is widely used in the treatments of breast, lung and ovarian cancer. The elucidation of the taxol biosynthetic pathway is the key to solve the problem of taxol supply.
Tao Wang +6 more
doaj +2 more sources
Genome-Wide Analysis of bZIP Transcription Factors and Expression Patterns in Response to Shading Treatment in Taxus yunnanensis [PDF]
Current Issues in Molecular BiologyBasic leucine zipper (bZIP) transcription factors are widely involved in plant growth, development, environmental adaptation, and secondary metabolism. However, the bZIP gene family in Taxus yunnanensis has not been systematically characterized, and its ...
Jiangtao Fan +8 more
doaj +2 more sources