Results 51 to 60 of about 31,992 (181)

Accelerating the prioritisation of plant species with underexplored medicinal potential: The pm4mp (Phylogenetic Methods for Medicinal Plants) R package

PLANTS, PEOPLE, PLANET, EarlyView.
Medicinal plants used in ethnobotanical traditions to treat or prevent diseases have gained renewed interest for their largely untapped potential in drug discovery. In this study, we developed and tested novel methods to prioritise plant species based on their unexplored medicinal potential. By enabling researchers to target the most promising species,
Giovanni Zecca, Elisa Toini, Massimo Labra, Fabrizio Grassi   +3 more
wiley   +1 more source

Separation of a tungus producing taxol [PDF]

, 2001
An endogenous filariform fungus has been separated from a tree named Taxus growing in the Aba region, Sichuan, China. The fungus is fermented in fluid medium for 3 weeks at 25 degreesC, then the HPLC and MALDI-TOF analysis of the zymotic fluid show that ...
Li, AM, Wan, B, Wan, B, Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China., Wang, XL   +3 more
core  

The performance of Taxol score in the training dataset. [PDF]

, 2018
The survival of Taxol-receiving and Taxol-depleted groups was comparable in the high Taxol score group (A), while survival of the Taxol-receiving group was significantly better than the Taxol-depleted group in the low Taxol score group (B). The Taxol and
Jianrong Dai (517364), Shunyu Hou (4903546)   +1 more
core   +1 more source

Combined decitabine and Taxol induce MCF-7/Taxol cells pyroptosis. [PDF]

, 2023
A. The integrity of cell membrane was determined by the LDH release assay of breast cancer cells with 640nM Taxol. B. Flow cytometry was used to detect the incidence of pyroptosis in breast cancer cells treated with 640nM Taxol for 24h. C. The expression
Maodong Leng (14716900), Ying Shi (115282), Weihua Gong (471435), Panpan Fang (5476334)   +3 more
core   +1 more source

Allicin: A natural weapon against Taxol resistance in non‐small cell lung cancer through Cathepsin B inhibition and lysosomal‐autophagy disruption

Food Frontiers
Drug resistance in non‐small cell lung cancer (NSCLC) limits its therapeutic efficacy. Allicin may help to solve the problem of Taxol resistance in NSCLC.
Xudong Gao, Chang Xu, Ramesh Kumar Santhanam, Yingshi Zhang, Qingchun Zhao   +4 more
doaj   +1 more source

Lysophosphatidate induces chemo-resistance by releasing breast cancer cells from taxol-induced mitotic arrest.

PLoS ONE, 2011
BackgroundTaxol is a microtubule stabilizing agent that arrests cells in mitosis leading to cell death. Taxol is widely used to treat breast cancer, but resistance occurs in 25-69% of patients and it is vital to understand how Taxol resistance develops ...
Nasser Samadi, Raie T Bekele, Ing Swie Goping, Luis M Schang, David N Brindley   +4 more
doaj   +1 more source

High expression of RIPK2 is associated with Taxol resistance in serous ovarian cancer

Journal of Ovarian Research, 2022
Background Taxol resistance in serous ovarian cancer is responsible for its poor prognosis, yet the underlying mechanism is still poorly understood. Thus, we probed the mechanism of Taxol resistance in serous ovarian cancer with multiple bioinformatic ...
Yuqing Shen, Hui Lin, Kelie Chen, Wanzhong Ge, Dajing Xia, Yihua Wu, Weiguo Lu   +6 more
doaj   +1 more source

Salicylic Acid-Responsive Factor TcWRKY33 Positively Regulates Taxol Biosynthesis in Taxus chinensis in Direct and Indirect Ways

Frontiers in Plant Science, 2021
Taxol is a rare secondary metabolite that accumulates considerably in Taxus species under salicylic acid (SA) and methyl jasmonate treatment. However, the molecular mechanism of its accumulation remains unclear.
Ying Chen, Ying Chen, Ying Chen, Hua Zhang, Hua Zhang, Hua Zhang, Meng Zhang, Meng Zhang, Meng Zhang, Wenli Zhang, Wenli Zhang, Wenli Zhang, Ziqi Ou, Ziqi Ou, Ziqi Ou, Zehang Peng, Zehang Peng, Zehang Peng, Chunhua Fu, Chunhua Fu, Chunhua Fu, Chunfang Zhao, Chunfang Zhao, Chunfang Zhao, Longjiang Yu, Longjiang Yu, Longjiang Yu   +26 more
doaj   +1 more source

Ischaemic stroke and 5‐fluorouracil or capecitabine: A systematic review and meta‐analysis of harms and a retrospective study of the WHO pharmacovigilance database

British Journal of Pharmacology, EarlyView.
Abstract Aim Fluoropyrimidines, including 5‐fluorouracil (5‐FU) and capecitabine, are cornerstone antineoplastic agents for cancer. Case reports suggest that these drugs may be associated with an under‐recognised risk of ischaemic stroke or transient ischaemic attack (TIA).
Sophie Nguyen, Ines Bentahrour, Camille Guerin, Charles Dolladille, Angélique Da Silva, François Cherifi, Elise‐Marie Minoc, Pierre‐Marie Morice, Nicolas Jacquin, Christophe Le Tourneau, Joachim Alexandre, Ahmad Nehme, Etienne Bastien   +12 more
wiley   +1 more source

Persistent in vitro nociceptor hyperexcitability and axonal retraction produced by repeated paclitaxel doses

The FEBS Journal, EarlyView.
Repeated paclitaxel exposure causes long‐lasting nociceptor hyperexcitability and axonal retraction in adult sensory neurons. Using a long‐term primary nociceptor culture, we show that hyperexcitability is mediated by sequential upregulation of NaV1.8, TRPV1, TRPA1, and TRPM8 channels.
Angela Lamberti, Victor Moreno Lozano, Asia Fernández‐Carvajal, Antonio Ferrer‐Montiel   +3 more
wiley   +1 more source