High expression of RIPK2 is associated with Taxol resistance in serous ovarian cancer [PDF]
Journal of Ovarian Research, 2022 Background Taxol resistance in serous ovarian cancer is responsible for its poor prognosis, yet the underlying mechanism is still poorly understood. Thus, we probed the mechanism of Taxol resistance in serous ovarian cancer with multiple bioinformatic ...
Yuqing Shen +6 more
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Circular RNA circ_0006168 enhances Taxol resistance in esophageal squamous cell carcinoma by regulating miR-194-5p/JMJD1C axis [PDF]
Cancer Cell International, 2021 Background Chemoresistance is one of the major obstacles for cancer therapy in the clinic. Circular RNAs (circRNAs) are involved in the pathogenesis of esophageal squamous cell carcinoma (ESCC) and chemoresistance.
Fanyong Qu +5 more
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Interfering cellular lactate homeostasis overcomes Taxol resistance of breast cancer cells through the microRNA-124-mediated lactate transporter (MCT1) inhibition [PDF]
Cancer Cell International, 2019 Background Breast cancer, the most common invasive cancer of women, is a malignant neoplasm and the second main cause of cancer death. Resistance to paclitaxel (Taxol), one of the frequently used chemotherapy agents for breast cancer, presents a major ...
Lu Hou +7 more
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Screening a living biobank identifies cabazitaxel as a strategy to combat acquired taxol resistance in high-grade serous ovarian cancer [PDF]
Cell Reports MedicineSummary: The anti-mitotic agent taxol (paclitaxel) remains a cornerstone of ovarian cancer treatment. To tackle drug resistance and toxicity, second-generation targeted anti-mitotic agents and combination strategies are being explored but have yet to ...
Anthony Tighe +9 more
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Distinct Mitochondrial Recovery Dynamics Following Taxol Removal in Triple-Negative Breast Cancer Cells [PDF]
CellsDrug resistance in TNBC is associated with metabolic plasticity, yet little is known about how mitochondrial and cellular states evolve after chemotherapeutic withdrawal.
Jack Kollmar +4 more
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Chromatin-focused genetic and chemical screens identify BRPF1 as a targetable vulnerability in Taxol-resistant triple-negative breast cancer [PDF]
Experimental and Molecular MedicineTriple-negative breast cancer (TNBC) is a particularly aggressive and frequently recurring form of breast cancer, where chemotherapy is the primary treatment approach.
Ozlem Yedier-Bayram +16 more
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Circular RNA Circ_0002360 Regulates the Taxol Resistance and Malignant Behaviors of Taxol-Resistant Non-Small Cell Lung Cancer Cells by microRNA-585-3p-Dependent Modulation of G Protein Regulated Inducer of Neurite Outgrowth 1 [PDF]
Bioengineered, 2022 Xinju Li
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NOXA/MCL-1 axis determines cell-death decision between apoptosis and a GSDME-dependent cell death associated with production of inflammatory cytokines upon treatment of breast cancer cells with antimitotics [PDF]
Cell Death and DiseaseUnderstanding how malignant cells respond to chemotherapy is essential to prevent the development of resistance and to improve the efficiency of anticancer drugs. Antimitotic treatment in breast cancer cells increases NOXA, an endogenous inhibitor of the
Alison Dumont +7 more
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Inhibition of EREG/ErbB/ERK by Astragaloside IV Reversed Taxol-Resistance of Non-Small Cell Lung Cancer Through Attenuation of Stemness via TGFβ and Hedgehog Signal Pathway [PDF]
Cellular Oncology (Dordrecht)Xiaofeng Yan, Tingjie ye, Changtai Qin
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Mdivi-1 induces spindle abnormalities and augments taxol cytotoxicity in MDA-MB-231 cells
Cell Death Discovery, 2021 Taxol is a first-line chemotherapeutic for numerous cancers, including the highly refractory triple-negative breast cancer (TNBC). However, it is often associated with toxic side effects and chemoresistance in breast cancer patients, which greatly limits
Chieh-Ting Fang +4 more
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