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Cancer Chemotherapy and Pharmacology, 1999
Eleutherobin, a natural product, is an antimitotic agent that promotes the polymerization of stable microtubules. Although its mechanism of action is similar to that of Taxol, its structure is distinct. A structure-activity profile of synthetic eleutherobin derivatives that have modifications at C3, C8 and C15 was undertaken to define the structural ...
H M, McDaid +7 more
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Eleutherobin, a natural product, is an antimitotic agent that promotes the polymerization of stable microtubules. Although its mechanism of action is similar to that of Taxol, its structure is distinct. A structure-activity profile of synthetic eleutherobin derivatives that have modifications at C3, C8 and C15 was undertaken to define the structural ...
H M, McDaid +7 more
openaire +2 more sources
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2013
To compare the difference in gene expression profiles between parental cell line and drug resistant cell line (CNE-1 and CNE-1/taxol) pre-treated or treated by drugs, and search for genes related to taxol resistance and reversal of taxol resistance phenotype.cDNA microarray was used to detect the difference in gene expression profiles between 6 groups ...
Xiaowei, Peng, Guolin, Tan
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To compare the difference in gene expression profiles between parental cell line and drug resistant cell line (CNE-1 and CNE-1/taxol) pre-treated or treated by drugs, and search for genes related to taxol resistance and reversal of taxol resistance phenotype.cDNA microarray was used to detect the difference in gene expression profiles between 6 groups ...
Xiaowei, Peng, Guolin, Tan
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Antitumor effect of taxol-containing liposomes in a taxol-resistant murine tumor model.
Cancer research, 1994Taxol is a promising agent for use in ovarian cancer and other malignancies. One problem associated with taxol is its low aqueous solubility, requiring Cremophor EL (polyethoxylated castor oil) and ethanol as excipients (Diluent 12); these agents cause serious adverse effects.
A, Sharma, E, Mayhew, R M, Straubinger
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[Development of research for drug-resistance mechanism of taxol].
Ai zheng = Aizheng = Chinese journal of cancer, 2003The resistant problem is the main restriction factor for clinical usage of taxol. The main mechanism of its resistance includes the high expression of P-gp, beta- and alpha-tubulin isotypes, the alteration expression of PKC, Bcl-2, p53, and ErbB2. The reversing method includes the use of analogues of taxol to reduce the expression of P-gp, or the use ...
Fang, Wang, Rui, Han
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New Agents for Taxol-Resistant Breast Adenocarcinoma
2003Abstract : Taxol has proven to be a valuable addition to the chemotherapeutic regimens that can be offered to breast cancer patients; however, as with other drugs, evidence for resistance to Taxol has emerged. Among these resistance mechanisms is the P-gp 170 membrane-associated drug-efflux pump, for which the active agent, paclitaxel, is a substrate ...
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TLR4 and NFκB signaling is critical for taxol resistance in ovarian carcinoma cells
Journal of Cellular Physiology, 2017We report here that toll‐like receptor 4 (TLR4) and ABCB1 are upregulated in SKOV3 ovarian carcinoma cells that acquired resistance to the anticancer drug taxol. Silencing of TLR4 using short‐hairpin RNA sensitized taxol‐resistant SKOV3 cells to taxol (4.6 fold), whereas ectopic expression of TLR4 in parental, taxol‐sensitive SKOV3 cells or TLR4‐null ...
Nian‐Kang Sun +3 more
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New Agents for Taxol-Resistant Ovarian Carcinoma
2002Abstract : Taxol resistance is an important issue in relapsing ovarian cancer. Two approaches to address this resistance include the use of drug copolymers and drug targeting. In this proposal, paclitaxel covalently coupled to backbones of poly(L-glutamic) acid (non- targeted) or hyaluronic acid (CD44 targeted) as prodrugs will be evaluated in CD44 ...
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A phosphoglycoprotein associated with taxol resistance in J774.2 cells.
Cancer research, 1985Taxol is an inhibitor of cell replication that promotes the assembly of microtubules in vitro and in cells. In the murine macrophage-like cell line J774.2, a taxol-resistant subline (J7/TAX-50) has been developed in vitro by growing the cells in increasing drug concentrations.
S N, Roy, S B, Horwitz
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Cisplatin, camptothecin, and taxol sensitivities of cells with p53-associated multidrug resistance.
Molecular Pharmacology, 1996With the use of clonogenic survival assays, we show that wild-type p53-expressing A2780 human ovarian cell lines transfected with a dominant negative mutant p53 gene (codon 143, valine to alanine) acquired cross-resistance to ionizing radiation, cisplatin, doxorubicin, and 1-beta-D-arabinofuranosylcytosine.
Vasey, Paul A. +4 more
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Taxol Resistance and Microtubule Dynamics in Breast Cancer
2002Abstract : Alterations to microtubule dynamics, leading to a less stable polymer, may be a crucial determinant in the development of resistance towards Taxol, and other drugs with a binding site on the microtubule polymer. We propose that two potential mechanisms by which breast cancer cells could alter their microtubule dynamics are by (1 ...
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