Results 41 to 50 of about 2,363,919 (190)

Lactate dehydrogenase B is associated with the response to neoadjuvant chemotherapy in oral squamous cell carcinoma. [PDF]

PLoS ONE, 2015
Oral squamous cell carcinoma (OSCC) comprises a subset of head and neck squamous cell carcinoma (HNSCC) with poor therapeutic outcomes and high glycolytic dependency.
Wenyi Sun, Xiaomin Zhang, Xu Ding, Huaiqi Li, Meiyu Geng, Zuoquan Xie, Heming Wu, Min Huang   +7 more
doaj   +1 more source

The Blocking of Drug Resistance Channels by Selected Hydrophobic Statins in Chemoresistance Human Melanoma

Biomolecules, 2023
Despite the development of modern drugs, drug resistance in oncology remains the main factor limiting the curability of patients. This paper shows the use of a group of hydrophobic statins to inhibit drug resistance (Pgp protein).
Wojciech Placha, Piotr Suder, Agnieszka Panek, Patrycja Bronowicka-Adamska, Marta Zarzycka, Małgorzata Szczygieł, Jacek Zagajewski, Monika Weronika Piwowar   +7 more
doaj   +1 more source

Expression of taxol resistance gene 1 correlates with gastric cancer patient clinical outcome and induces taxol resistance

Molecular Medicine Reports, 2010
In the present study, we investigated the effect of the taxol resistance gene 1 (TXR1) on taxol resistance in gastric cancer (GC). Immunohistochemistry was performed in order to assess the expression pattern of TXR1 in paraffin-embedded specimens of 107 GC patients who underwent radical D2 gastrectomy with long-term follow-up.
Zhi-Gang, Bai, Xiang, Qu, Wei, Han, Xue-Mei, Ma, Xiao-Mu, Zhao, Zhong-Tao, Zhang   +5 more
openaire   +3 more sources

DHW-221, a Dual PI3K/mTOR Inhibitor, Overcomes Multidrug Resistance by Targeting P-Glycoprotein (P-gp/ABCB1) and Akt-Mediated FOXO3a Nuclear Translocation in Non-small Cell Lung Cancer

Frontiers in Oncology, 2022
Multidrug resistance (MDR) is considered as a primary hindrance for paclitaxel failure in non-small cell lung cancer (NSCLC) patients, in which P-glycoprotein (P-gp) is overexpressed and the PI3K/Akt signaling pathway is dysregulated.
Mingyue Liu, Chang Xu, Xiaochun Qin, Wenwu Liu, Deping Li, Hui Jia, Xudong Gao, Yuting Wu, Qiong Wu, Xiangbo Xu, Bo Xing, Xiaowen Jiang, Hongyuan Lu, Yingshi Zhang, Huaiwei Ding, Huaiwei Ding, Qingchun Zhao, Qingchun Zhao   +17 more
doaj   +1 more source

CRM197 reverses paclitaxel resistance by inhibiting the NAC‐1/Gadd45 pathway in paclitaxel‐resistant ovarian cancer cells

Cancer Medicine, 2019
Heparin‐binding epidermal growth factor‐like growth factor (HB‐EGF) is a new promising target for the treatment of ovarian cancer. Our previous study showed that cross‐reacting material 197 (CRM197), a specific HB‐EGF inhibitor, significantly reverses ...
Xiao‐han Tang, Hui Li, Xiu‐shuang Zheng, Mei‐song Lu, Yuan An, Xiao‐lei Zhang   +5 more
doaj   +1 more source

Action of the plant-based essential oil-derived compound Taxol for improvising drought tolerance in Eucalyptus by modulating the VIT1 channel protein: a cutting-edge computational approach

Frontiers in Genetics, 2023
Background: Drought poses a significant threat to the growth and survival of woody plants, especially Eucalyptus grandis, which is known for its slow and steady growth. Understanding the physiological and molecular responses of E.
Chen Xu, Sandip Debnath, Asad Syed, Abdallah M. Elgorban, Ali H. Bahkali, Rajalakahmanen Eswaramaathy, Meenakshi Verma, Md Mostofa Uddin Helal, Xing Jian   +8 more
doaj   +1 more source

In Silico Exploration of Microtubule Agent Griseofulvin and Its Derivatives Interactions with Different Human β-Tubulin Isotypes

Molecules, 2023
Tubulin isotypes are known to regulate microtubule stability and dynamics, as well as to play a role in the development of resistance to microtubule-targeted cancer drugs. Griseofulvin is known to disrupt cell microtubule dynamics and cause cell death in
Parisa Aris, Masoud Mohamadzadeh, Alibek Kruglikov, Mahbubeh Askari Rad, Xuhua Xia   +4 more
doaj   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Purification, Fluorescent Labeling, and Detyrosination of Mammalian Cell Tubulin for Biochemical Assays

Cytoskeleton, EarlyView.
ABSTRACT Microtubules play essential roles in numerous cellular processes. All microtubules are built from the protein tubulin, yet individual microtubules can differ spatially and temporally due to their tubulin isotype composition and post‐translational modifications (PTMs).
Ezekiel C. Thomas, Yang Yue, Morgan L. Pimm, Takashi Hotta, Ryoma Ohi, Kristen J. Verhey   +5 more
wiley   +1 more source

Down-regulated βIII-tubulin Expression Can Reverse Paclitaxel Resistance in A549/Taxol Cells Lines

Chinese Journal of Lung Cancer, 2014
Background and objective Chemotherapy drug resistance is the primary causes of death in patients with pulmonary carcinoma which make tumor recurrence or metastasis. β-tubulin is the main cell targets of anti-microtubule drug. Increased expression of βIII-
Yinling ZHUO, Qisen GUO
doaj   +1 more source