Results 61 to 70 of about 2,363,919 (190)

Protection of p53 wild type cells from taxol by nutlin-3 in the combined lung cancer treatment

BMC Cancer, 2010
Background Mutations within the tumor suppressor TP53 gene are one of the most common genetic alterations present at high frequency in human tumors and have been shown to be associated with resistance to radio-chemotherapy. The lack of the wild type TP53
Abolmaali Nasreddin D, Tokalov Sergey V
doaj   +1 more source

Inhibition of P‐glycoprotein using photoimmunotherapy in peritoneal metastasis mouse model

Photochemistry and Photobiology, EarlyView.
Photoimmunotherapy (PIT) using photoimmunoconjugates (PICs) can inhibit the function of the ATP‐binding cassette (ABC) transporter P‐glycoprotein (P‐gp) in a mouse model of peritoneal carcinomatosis. Sterile‐filtered PIC was administered in vivo via intraperitoneal (IP) injection 20 days after IP tumor cell implantation of P‐gp‐overexpressing NCI/ADR ...
Kaitlyn A. Moore, Brian Schnoor, Kathryn L. McNaughton, Idrisa Rahman, Benjamin D. Powers, Dana M. Roque, Huang‐Chiao Huang   +6 more
wiley   +1 more source

Enantioselective Total Synthesis of (−)-Taxol

, 2016
Enantioselective total synthesis of taxol has been accomplished. Coupling reaction of the optically pure A-ring hydroxy aldehyde with the aromatic C-ring fragment followed by Lewis acid mediated eight-membered B-ring cyclization gave the desired ABC endo-
Nobuhito Nakamura (3005613), Hiroyuki Kusama (1925068), Toshiyuki Nishimori (3005604), Ryoma Hara (2997180), Koichiro Morihira (3005610), Isao Kuwajima (2496277), Shigeru Kawahara (3005607), Hajime Kashima (2827205)   +7 more
core   +1 more source

Accelerating the prioritisation of plant species with underexplored medicinal potential: The pm4mp (Phylogenetic Methods for Medicinal Plants) R package

PLANTS, PEOPLE, PLANET, Volume 8, Issue 6, Page 2061-2079, November 2026.
Medicinal plants used in ethnobotanical traditions to treat or prevent diseases have gained renewed interest for their largely untapped potential in drug discovery. In this study, we developed and tested novel methods to prioritise plant species based on their unexplored medicinal potential. By enabling researchers to target the most promising species,
Giovanni Zecca, Elisa Toini, Massimo Labra, Fabrizio Grassi   +3 more
wiley   +1 more source

Polyphyllin H Reverses Paclitaxel Resistance in Breast Cancer by Binding Membrane Cholesterol to Inhibit Both ABCB1 and ABCC3

Pharmaceuticals
Background/Objectives: Breast cancer is the most prevalent malignancy among women, and paclitaxel (PTX) is a first-line chemotherapeutic, but chemoresistance driven by ATP-binding cassette (ABC) transporters limits its efficacy.
Zheng Ye, Chao Hong, Min Jiang, Wenkui Zou, Yaning Ren, Mingfang Li, Xinyue Xue, Xiaoting Xie, Tong Zhang, Yue Ding   +9 more
doaj   +1 more source

Natural Product‐Induced Ferroptosis to Overcome Therapy Resistance in Aggressive Cancers

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
Natural products trigger ferroptosis through iron overload, glutathione depletion, glutathione peroxidase 4 inhibition, and reactive oxygen species accumulation, selectively targeting aggressive, and drug‐resistant cancers. Polyphenols, alkaloids and terpenoids emerge as promising multi‐target agents to overcome therapy resistance and improve future ...
Giorgio Antoniolli
wiley   +1 more source

Feasibility of multi‐energy CT and fat fraction MRI for characterizing active bone marrow response to pelvic external beam radiation therapy

Journal of Applied Clinical Medical Physics, Volume 27, Issue 10, October 2026.
Abstract Background Pelvic external beam radiation therapy (EBRT), frequently exposes a substantial fraction of active bone marrow (ABM), leading to radiation‐induced marrow suppression and associated hematologic toxicity. Accurate delineation and quantitative assessment of ABM are therefore essential to enable marrow‐sparing radiotherapy strategies ...
Carolyn Eckrich, Kristin Bradley, Bethany Anderson, Diego Hernando, Jessica Miller, Jainil Shah, Patrick Wohlfahrt, Michael Lawless   +7 more
wiley   +1 more source

Resistance to Taxol in lung cancer cells associated with increased microtubule dynamics [PDF]

Proceedings of the National Academy of Sciences, 2001
Microtubule dynamics are crucial for mitotic spindle assembly and chromosome movement. Suppression of dynamics by Taxol appears responsible for the drug's potent ability to inhibit mitosis and cell proliferation. Although Taxol is an important chemotherapeutic agent, development of resistance limits its efficacy. To examine the role of microtubule
A, Gonçalves, D, Braguer, K, Kamath, L, Martello, C, Briand, S, Horwitz, L, Wilson, M A, Jordan   +7 more
openaire   +2 more sources

Synergistic enhancement of efficacy of platinum drugs with verteporfin in ovarian cancer cells

BMC Cancer, 2020
Background Epithelial ovarian cancers (EOCs) comprises the majority of malignant ovarian neoplasms. Combination treatment with chemotherapeutic agents seems to be a promising strategy in ovarian cancer (OVCA) patients in order to overcome drug resistance.
Venkata Ramesh Dasari, David J. Carey, Radhika Gogoi   +2 more
doaj   +1 more source

Ethnomedicinal and Phytopharmaceutical Properties of Syzygium samarangense (Blume) Merr. & L.M. Perry: A Gateway to Future Drug Development

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
ABSTRACT Recently, natural products and plant‐based regimens are widely recognized as potential complementary and alternative therapeutic solutions. Traditionally, ethnomedicinal knowledge, validated through scientific evidence, has been a basis for modern drug discovery, emphasizing the importance of updated phytopharmacological knowledge of medicinal
Sujit Kumar Patro, Rudra Narayan Sahoo, Ashirbad Nanda, Shasank S. Swain   +3 more
wiley   +1 more source