Results 81 to 90 of about 13,784 (200)

Polyphyllin H Reverses Paclitaxel Resistance in Breast Cancer by Binding Membrane Cholesterol to Inhibit Both ABCB1 and ABCC3

Pharmaceuticals
Background/Objectives: Breast cancer is the most prevalent malignancy among women, and paclitaxel (PTX) is a first-line chemotherapeutic, but chemoresistance driven by ATP-binding cassette (ABC) transporters limits its efficacy.
Zheng Ye, Chao Hong, Min Jiang, Wenkui Zou, Yaning Ren, Mingfang Li, Xinyue Xue, Xiaoting Xie, Tong Zhang, Yue Ding   +9 more
doaj   +1 more source

Integrating Artificial Intelligence Into Drug Discovery From Medicinal Plants: Current Applications and Infrastructural Challenges

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
This review presents a systems‐oriented roadmap for integrating artificial intelligence into medicinal plant drug discovery to overcome persistent bottlenecks like extract complexity. It highlights that advancing toward reproducible therapeutics requires making phytochemical datasets AI‐ready via rigorous harmonization and phyto‐centric foundational ...
Amit Gangwal, Azim Ansari, Mohd Usman Mohd Siddique, Jyotiram Sawale, Suhas Padmane, Raju Wadekar   +5 more
wiley   +1 more source

Synergistic enhancement of efficacy of platinum drugs with verteporfin in ovarian cancer cells

BMC Cancer, 2020
Background Epithelial ovarian cancers (EOCs) comprises the majority of malignant ovarian neoplasms. Combination treatment with chemotherapeutic agents seems to be a promising strategy in ovarian cancer (OVCA) patients in order to overcome drug resistance.
Venkata Ramesh Dasari, David J. Carey, Radhika Gogoi   +2 more
doaj   +1 more source

Molecular imaging of the kinetics of hyperactivated ERK1/2-mediated autophagy during acquirement of chemoresistance

Cell Death and Disease, 2021
Alterations in key kinases and signaling pathways can fine-tune autophagic flux to promote the development of chemoresistance. Despite empirical evidences of strong association between enhanced autophagic flux with acquired chemoresistance, it is still ...
Aniketh Bishnu, Pratham Phadte, Ajit Dhadve, Asmita Sakpal, Bharat Rekhi, Pritha Ray   +5 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, Volume 20, Issue 7, Page 1667-1693, July 2026.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Blocking lncRNA HCG18 re-sensitizes Taxol resistant lung cancer cells to Taxol through modulating the miR-34a-5p/HDAC1 axis [PDF]

Lung cancer is one of the most frequently diagnosed cancers worldwide, associated with a poor survival rate. Taxol (Paclitaxel) is commonly used as a chemotherapeutic treatment for advanced lung cancers.
Juan Wang (115708), Qiuyue Xu (8931536), Lin Liu (74495), Kai Yang (73590), Zijie Liu (2319538), Xiaoyu Luo (575148), Rong Gong (3496781), Haoyu Li (1672648), Fujun Zhang (588079), Yunmin Xu (18507480)   +9 more
core   +1 more source

Up-regulation of GSTT1 in serous ovarian cancer associated with resistance to TAXOL / carboplatin

Journal of Ovarian Research, 2021
Serous ovarian cancer (SOC) is the most common women cancer and the leading cause of cancer-related mortality among the gynaecological malignancies. Although effective chemotherapeutics combined with surgery are developed for the treatment, the five-year
Jing Zhang, Suhong Xie, Lei Zhou, Xiaoyu Tang, Xiaolin Guan, Minjie Deng, Hui Zheng, Yanchun Wang, Renquan Lu, Lin Guo   +9 more
doaj   +1 more source

Resistance to Taxol in lung cancer cells associated with increased microtubule dynamics [PDF]

Proceedings of the National Academy of Sciences, 2001
Microtubule dynamics are crucial for mitotic spindle assembly and chromosome movement. Suppression of dynamics by Taxol appears responsible for the drug's potent ability to inhibit mitosis and cell proliferation. Although Taxol is an important chemotherapeutic agent, development of resistance limits its efficacy. To examine the role of microtubule
A, Gonçalves, D, Braguer, K, Kamath, L, Martello, C, Briand, S, Horwitz, L, Wilson, M A, Jordan   +7 more
openaire   +2 more sources

Natural Products as Modulators of ABC Transporters in Breast Cancer

Phytotherapy Research, Volume 40, Issue 7, Page 4611-4637, July 2026.
ABSTRACT Breast cancer remains a significant global health challenge, with high incidence and mortality rates despite advancements in early detection and treatment. Multidrug resistance (MDR), particularly in aggressive subtypes like triple‐negative breast cancer (TNBC), continues to hinder effective therapy.
Yoganishalini Sagadevan, Reyhaneh Farghadani, Ammu K. Radhakrishnan   +2 more
wiley   +1 more source

Development of Ultrasound Microbubbles and Phase Shift Microbubbles in Theranostics

WIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 4, July/August 2026.
Microbubbles have been originally designed for diagnostic applications. Over the years, microbubbles and phase shift microbubbles have been further developed for therapeutic indications. ABSTRACT Ultrasound is widely used for diagnostic imaging and therapy.
Emmanuelle J. Meuillet, Evan C. Unger
wiley   +1 more source