Genome-wide DNA methylation analysis of breast cancer MCF-7 / Taxol cells with MeDIP-Seq.
PLoS ONE, 2020 Breast cancer (BC) is the most frequently diagnosed tumor in women worldwide. Although the combination of surgery and Taxol chemotherapy can achieve a certain therapeutic effect, patients often develop drug-resistance, resulting in a poor prognosis ...
Ying Shi +4 more
doaj +1 more source
Molecular Medicine Reports, 2015 Malignant gliomas, which comprise the most common type of primary malignant brain tumor, are associated with a poor prognosis and quality of life. Paclitaxel (Taxol) and temozolomide (TMZ) are Food and Drug Administration‑approved anticancer agents, which are known to have therapeutic applications in various malignancies.
Ding-Guo, Guan +3 more
openaire +3 more sources
Pharmacological modulation and manipulation of cancer drug resistance [PDF]
, 2010 The aim of this project was to investigate pharmacological methods of overcoming resistance in cancer. Novel compounds, targeted therapies and non-steroidal anti-inflammatory drugs (NSAIDs) were examined for their potential to modulate and manipulate ...
Devery, Aoife
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lncRNA-DANCR Promotes Taxol Resistance of Prostate Cancer Cells through Modulating the miR-33b-5p-LDHA Axis. [PDF]
Dis Markers, 2022 Wang YY, Chen C.
europepmc +1 more source
Mcl-1 stabilization confers resistance to taxol in human gastric cancer
Oncotarget, 2017 Taxol has been extensively used as an antineoplastic drug to treat human gastric cancer. However, the acquired drug resistance invariably develops and greatly limits the therapeutic efficacy of Taxol. Identification of the underlying resistance mechanisms may inform the development of new therapies of gastric cancers to Taxol treatment.
Shuang, Wu +4 more
openaire +3 more sources
CYR61 Expression Promotes Taxol Resistance: A Molecular Link with the p53 in Breast. [PDF]
, 2009 CYR61 render human breast cancer cells highly resistance to the microtubule-interfering agent Taxol, a drug of choice for the treatment of metastatic breast cancer.
I. Espinoza, R. Lupu
core +1 more source
CD133+/ABCC5+ cervical cancer cells exhibit cancer stem cell properties
HeliyonObjective: This study explores the correlation between Forkhead box M1 (FOXM1) and ATP-binding cassette subfamily C member 5 (ABCC5) in relation to paclitaxel resistance in cervical cancer. It aims to identify potential cervical cancer stem cell markers,
Lin He +7 more
doaj +1 more source
Circular RNA hsa_circ_0011298 enhances Taxol resistance of non-small cell lung cancer by regulating miR-486-3p/CRABP2 axis. [PDF]
J Clin Lab Anal, 2022 Wu Y, Xie J, Wang H, Hou S, Feng J.
europepmc +1 more source
BMC CancerBackground The main challenge in treating ovarian cancer is chemotherapy resistance. Previous studies have shown that PAK2 is highly expressed in various cancers.
Ting Shuang +4 more
doaj +1 more source
Carboplatin and taxol resistance develops more rapidly in functional BRCA1 compared to dysfunctional BRCA1 ovarian cancer cells [PDF]
, 2014 A major risk factor for ovarian cancer is germline mutations of BRCA1/2. It has been found that (80%) of cellular models with acquired platinum or taxane resistance display an inverse resistance relationship, that is collateral sensitivity to the other ...
O\u27LEARY, JOHN +2 more
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