Results 71 to 80 of about 2,363,919 (190)
Cell Death and Disease, 2021 Alterations in key kinases and signaling pathways can fine-tune autophagic flux to promote the development of chemoresistance. Despite empirical evidences of strong association between enhanced autophagic flux with acquired chemoresistance, it is still ...
Aniketh Bishnu +5 more
doaj +1 more source
Oncology Letters, 2015 The development of chemoresistance in patients represents a major challenge in cancer treatment. Lactate dehydrogenase-A (LDHA) is one of the principle isoforms of LDH that is expressed in breast tissue, controlling the conversion of pyruvate to lactate and also playing a significant role in the metabolism of glucose.
FENG, LIN +6 more
openaire +3 more sources
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.ABSTRACT Chemotherapy commonly induces skeletal muscle dysfunction and cognitive impairment, complications that reduce treatment tolerance and quality of life. Skeletal muscle mass frequently declines during chemotherapy, with cohort studies reporting losses of 3%–10% across treatment courses, while chemotherapy‐induced cognitive impairment affects up ...
SoYoung Ahn +10 more
wiley +1 more source
, 2007 TWIST, a basic helix-loop-helix transcription factor, has been reported to be associated with development and progression of human cancer. Recently, over expression of TWIST is found in cancer patients with shorter survival and poor response to ...
Leung, SCL +5 more
core +1 more source
Frontiers in Pharmacology, 2019 Local recurrence after therapy remains a challenging problem for hypopharyngeal cancer (HPC) due to the chemotherapy resistance. Metformin is associated with reduced cancer risk through promoting global DNA methylation in cancer cells by controlling S ...
Ping Wu +6 more
doaj +1 more source
Small, Volume 22, Issue 59, 22 October 2026.Scaling nanofluidic channel geometries to sub‐200 nm is demonstrated to suppress junction guiding errors in network‐based biocomputing. The resulting increase in path fidelity enables experimental solution of Exact Cover instances with more than 33 million possible solutions, establishing a new benchmark for network‐based biocomputing. ABSTRACT Network‐
Eugene Christo V R +8 more
wiley +1 more source
Upregulation of caveolin‐1 and caveolae organelles in Taxol‐resistant A549 cells
FEBS Letters, 1998 Caveolin is a principal component of caveolae membranes. It has been demonstrated that the interaction of the caveolin scaffolding domain with signaling molecules can functionally inhibit the activity of these molecules. Taxol is an antitumor agent that suppresses microtubule dynamics and binds to microtubules thereby stabilizing them against ...
Yang, Chia-Ping Huang +4 more
openaire +2 more sources
Evolution‐Inspired Engineering of Diterpene Biosynthesis via Chloroplast Genome Modification
Plant Biotechnology Journal, Volume 24, Issue 10, Page 5510-5525, October 2026.ABSTRACT Terpenes constitute the largest and most structurally diverse class of plant secondary metabolites, with critical roles in plant‐environment interactions and broad industrial applications. Although nuclear genome engineering of terpene pathways has been extensively explored, chloroplast genome engineering remains largely undeveloped, with most
Alessandro Occhialini +6 more
wiley +1 more source
Molecular Oncology, Volume 20, Issue 9, Page 2243-2261, September 2026.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Neoplasia: An International Journal for Oncology Research, 2014 Since loss of VHL is frequently detected early phase genetic event in human renal cell carcinoma, pVHL is assumed to be indispensable for suppression of tumor initiation step.
Youn-Sang Jung +3 more
doaj +1 more source