Results 31 to 40 of about 2,363,919 (190)

Extreme low dose of 5-fluorouracil reverses MDR in cancer by sensitizing cancer associated fibroblasts and down-regulating P-gp. [PDF]

PLoS ONE, 2017
We conducted a prospective, meaningful study of extreme low dose of 5-fluorouracil (5FU) as a metronomic agent targeting cancer associated fibroblasts (CAFs) to reverse Multidrug resistance (MDR) by sensitizing cancer associated fibroblasts and down ...
Yan Ma, Yuhua Wang, Zhenghong Xu, Yongjun Wang, John K Fallon, Feng Liu   +5 more
doaj   +1 more source

Biological characteristics of Taxol-resistant ovarian cancer cells and reversal of Taxol resistance by adenovirus expressing p53

Molecular Medicine Reports, 2014
The development of acquired drug resistance is the primary cause of chemotherapy failure in the treatment of ovarian cancer. To examine the mechanism underlying Taxol (TAX) resistance in ovarian cancer and attempt to reverse it, the present study induced a TAX‑resistant ovarian cancer cell line SKOV3/TAX using a gradient concentration increment method.
Qun, Liu, Rui, Sui, Ruirui, Li, Jinwei, Miao, Jian, Liu   +4 more
openaire   +3 more sources

Profiles and Bioinformatics Analysis of Differentially Expressed Circrnas in Taxol-Resistant Non-Small Cell Lung Cancer Cells

Cellular Physiology and Biochemistry, 2018
Background/Aims: Circular RNAs (circRNAs) act as microRNA (miRNA) sponges that regulate gene expression and are involved in physiological and pathological processes.
Ning Xu, Shaomu Chen, Yufeng Liu, Wei Li, Zeyi Liu, Xiaojie Bian, Chunhua Ling, Min Jiang   +7 more
doaj   +1 more source

Sensitization of breast cancer cells to taxol by inhibition of taxol resistance gene 1

Oncology Letters, 2011
The purpose of this study was to determine the role of taxol resistance gene 1 (TXR1) in a taxol-resistant breast cancer cell line. Expression levels of TXR1 and thrombospondin-1 (TSP1) were detected by RT-PCR and Western blot analysis. In MCF-7 cells transfected with TXR1 plasmids, the expression of a number of drug resistance genes was monitored, as ...
Zhigang, Bai, Zhongtao, Zhang, Xiang, Qu, Wei, Han, Xuemei, Ma   +4 more
openaire   +3 more sources

Noncanonical Peloruside A Biosynthesis by an Uncultivated Verrucomicrobiota Symbiont

Angewandte Chemie, EarlyView.
Noncanonical biochemistry of the peloruside PKS characterized in this work, comprising double bond generation by a noncanonical tridomain (blue), acetyl‐CoA recycling (orange), and proofreading systems (purple and yellow). The Z‐double bond is installed by TEB1 through O‐acetylation and acetate elimination. The acyl ligase PelB (AL, orange) selectively
Amy E. Fraley, Michael Rust, Moritz Wagner, Ida R. Hipfinger, Paul J. N. Böhm, Cora L. Dieterich, Christopher M. Field, Michael J. Page, Jeremy G. Owen, Robert A. Keyzers, Shinichi Sunagawa, Jörn Piel   +11 more
wiley   +2 more sources

Silencing of glutaminase 1 resensitizes Taxol-resistant breast cancer cells to Taxol

Molecular Medicine Reports, 2015
Taxol is a front‑line chemotherapeutic agent for the treatment of patients with multiple types of tumor. However, resistance to Taxol remains one of the principal causes of cancer‑associated mortality. Glutamine, which is metabolized via a glutaminase (GLS)‑dependent process, termed glutaminolysis, is important in cell growth and metabolism.
Aiqin, Fu, Ze, Yu, Yaobo, Song, Enning, Zhang   +3 more
openaire   +3 more sources

Study of the Characterization of Side Population Cells in Endometrial Cancer Cell Lines: Chemoresistance, Progestin Resistance, and Radioresistance

Frontiers in Medicine, 2020
Introduction: Radiotherapy, combined regimens as platinum-paclitaxel chemotherapy and/or endocrine therapy is an important adjuvant treatment after surgery for endometrial cancer (EC). While, the resistance to them remain unclear.
Bing-jie Liu, Qi-ying Xu, Qi-ying Xu, Wei-dong Yu, Na Li, Tian Yao, Li-jun Zhao, Jian-liu Wang, Li-hui Wei, Xiao-ping Li   +9 more
doaj   +1 more source

An investigation of the role of the ErbB receptor family in chemotherapeutic drug resistance and invasion in human breast cancer [PDF]

, 2002
The purpose of the work described in this thesis was to investigate the effects of upregulation of c-erbB-2 by cDNA transfection and the downregulation by ribozyme transfection on chemotherapeutic drug sensitivity, in vitro invasion, and expression of a ...
Glynn, Sharon
core   +2 more sources

294 Identification of MCAK Inhibitors that Induce Aneuploidy in Triple Negative Breast Cancer Models

Journal of Clinical and Translational Science, 2023
OBJECTIVES/GOALS: Microtubule poisons, like Taxol, are used to treat triple negative breast cancer (TNBC) and may induce lethal aneuploidy in cancer cells. Patients initially respond, but often develop drug resistance.
John Smith, Stefan Husted, Jay Pilrose, Disha Kuchangi, Stephanie C. Ems-McClung, Richard L. Carpenter, Claire E. Walczak   +6 more
doaj   +1 more source

TMEM45A is essential for hypoxia-induced chemoresistance in breast and liver cancer cells

BMC Cancer, 2012
Background Hypoxia is a common characteristic of solid tumors associated with reduced response to radio- and chemotherapy, therefore increasing the probability of tumor recurrence.
Flamant Lionel, Roegiers Edith, Pierre Michael, Hayez Aurélie, Sterpin Christiane, De Backer Olivier, Arnould Thierry, Poumay Yves, Michiels Carine   +8 more
doaj   +1 more source