Results 11 to 20 of about 2,363,919 (190)
Autotaxin, lysophosphatidate and taxol resistance [PDF]
, 2009 First-line treatment of breast and other cancers with Taxol is compromised by resistance in up to 40% of patients. To improve chemotherapy, it is vital to understand how Taxol resistance develops and to overcome this. Autotaxin (ATX) promotes cancer cell survival, growth, migration, invasion and metastasis.
Samadi, Nasser
openaire +2 more sources
Warburg effect in chemosensitivity: Targeting lactate dehydrogenase-A re-sensitizes Taxol-resistant cancer cells to Taxol [PDF]
Molecular Cancer, 2010 Background Taxol is one of the most effective chemotherapeutic agents for the treatment of patients with breast cancer. Despite impressive clinical responses initially, the majority of patients eventually develop resistance to Taxol.
Riker Adam I +11 more
doaj +3 more sources
Platinum-Taxol non-cross resistance in epithelial ovarian cancer [PDF]
British Journal of Cancer, 1995 The aim of this study was to assess the clinical evidence for platinum-Taxol non-cross-resistance in patients with epithelial ovarian cancer. Unlike other studies, only patients who had demonstrably progressive disease on platinum therapy were analysed. Patients received 135-200 mg m-2 of Taxol over 3 or 24 h and all patients were assessed for response
Gore, M. E. +6 more
core +6 more sources
PLoS ONE, 2011 BackgroundTaxol is a microtubule stabilizing agent that arrests cells in mitosis leading to cell death. Taxol is widely used to treat breast cancer, but resistance occurs in 25-69% of patients and it is vital to understand how Taxol resistance develops ...
Nasser Samadi +4 more
doaj +2 more sources
BMC Cancer, 2018 Background Resistance to chemotherapy drugs (e.g. taxol) has been a major obstacle in successful cancer treatment. In A549 human lung adenocarcinoma, acquired resistance to the first-line chemotherapy taxol has been a critical problem in clinics ...
Hao Huang +6 more
doaj +2 more sources
Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells [PDF]
Drug Design, Development and Therapy, 2014 Yong-Wan Kim,1 Eun Young Kim,1 Doin Jeon,1 Juinn-Lin Liu,2 Helena Suhyun Kim,3 Jin Woo Choi,4 Woong Shick Ahn5 1Cancer Research Institute of Medical Science, The Catholic University of Korea, Seoul, Republic of Korea; 2Brain Tumor Center, Department of ...
Kim YW +6 more
doaj +3 more sources
Ecophysiological approaches to enhance production of the anti-cancer drug taxol by paraconiothyrium variabile and epiccocum nigrum and lysozyme by pichia pastoris [PDF]
, 2013 This study has investigated the interaction of ecophysiological factors such as water activity (aw), temperature, pH and solute types on (a) the production of the anti-cancer drug taxol by the endophytic fungi Parachoniothyrium variabile and Epcoccum ...
Somjaipeng, Supunnika
core +7 more sources
As a promising therapeutic target for cancer, CYP1B1 is overexpressed in Taxol-resistant A549 cells; however, its role in drug resistance still remains unclear.
Fengjiao Zhang (1605394) +8 more
core +13 more sources
The nature of the modification at position 37 of tRNAPhe correlates with acquired taxol resistance. [PDF]
Nucleic Acids Res, 2021 Abstract Acquired drug resistance is a major obstacle in cancer therapy. Recent studies revealed that reprogramming of tRNA modifications modulates cancer survival in response to chemotherapy. However, dynamic changes in tRNA modification were not elucidated. In this study, comparative analysis of the human cancer cell lines and their
Pan Y, Yan TM, Wang JR, Jiang ZH.
europepmc +4 more sources
Insulin-like growth factor 2 silencing restores taxol sensitivity in drug resistant ovarian cancer. [PDF]
PLoS ONE, 2014 Drug resistance is an obstacle to the effective treatment of ovarian cancer. We and others have shown that the insulin-like growth factor (IGF) signaling pathway is a novel potential target to overcome drug resistance.
Jurriaan Brouwer-Visser +5 more
doaj +1 more source