High expression of RIPK2 is associated with Taxol resistance in serous ovarian cancer [PDF]
Journal of Ovarian Research, 2022 Background Taxol resistance in serous ovarian cancer is responsible for its poor prognosis, yet the underlying mechanism is still poorly understood. Thus, we probed the mechanism of Taxol resistance in serous ovarian cancer with multiple bioinformatic ...
Yuqing Shen +6 more
doaj +7 more sources
Screening a living biobank identifies cabazitaxel as a strategy to combat acquired taxol resistance in high-grade serous ovarian cancer [PDF]
Cell Reports MedicineSummary: The anti-mitotic agent taxol (paclitaxel) remains a cornerstone of ovarian cancer treatment. To tackle drug resistance and toxicity, second-generation targeted anti-mitotic agents and combination strategies are being explored but have yet to ...
Anthony Tighe +9 more
doaj +4 more sources
Allicin: A natural weapon against Taxol resistance in non‐small cell lung cancer through Cathepsin B inhibition and lysosomal‐autophagy disruption [PDF]
Food FrontiersDrug resistance in non‐small cell lung cancer (NSCLC) limits its therapeutic efficacy. Allicin may help to solve the problem of Taxol resistance in NSCLC.
Xudong Gao +4 more
doaj +3 more sources
Circular RNA circ_0002360 regulates the Taxol resistance and malignant behaviors of Taxol-resistant non-small cell lung cancer cells by microRNA-585-3p-dependent modulation of G protein regulated inducer of neurite outgrowth 1 [PDF]
Bioengineered, 2022 Drug resistance has become the major obstacle for the treatment of non-small cell lung cancer (NSCLC). Circular RNAs (circRNAs) are tightly linked to the development of drug resistance of NSCLC. Herein, we tested the function of circ_0002360 in the Taxol
Xinju Li, Boxiang Zhang, Xiaohai Cui
exaly +4 more sources
Circular RNA circ_0006168 enhances Taxol resistance in esophageal squamous cell carcinoma by regulating miR-194-5p/JMJD1C axis [PDF]
Cancer Cell International, 2021 Background Chemoresistance is one of the major obstacles for cancer therapy in the clinic. Circular RNAs (circRNAs) are involved in the pathogenesis of esophageal squamous cell carcinoma (ESCC) and chemoresistance.
Fanyong Qu +5 more
doaj +2 more sources
Interfering cellular lactate homeostasis overcomes Taxol resistance of breast cancer cells through the microRNA-124-mediated lactate transporter (MCT1) inhibition [PDF]
Cancer Cell International, 2019 Background Breast cancer, the most common invasive cancer of women, is a malignant neoplasm and the second main cause of cancer death. Resistance to paclitaxel (Taxol), one of the frequently used chemotherapy agents for breast cancer, presents a major ...
Lu Hou +7 more
doaj +2 more sources
Warburg effect in chemosensitivity: Targeting lactate dehydrogenase-A re-sensitizes Taxol-resistant cancer cells to Taxol [PDF]
Molecular Cancer, 2010 Background Taxol is one of the most effective chemotherapeutic agents for the treatment of patients with breast cancer. Despite impressive clinical responses initially, the majority of patients eventually develop resistance to Taxol.
Riker Adam I +11 more
doaj +3 more sources
Mechanisms of Taxol resistance related to microtubules [PDF]
Oncogene, 2003 Since its approval by the FDA in 1992 for the treatment of ovarian cancer, the use of Taxol has dramatically increased. Although treatment with Taxol has led to improvement in the duration and quality of life for some cancer patients, the majority eventually develop progressive disease after initially responding to Taxol treatment.
Hayley Mcdaid +2 more
exaly +3 more sources
The nature of the modification at position 37 of tRNAPhe correlates with acquired taxol resistance. [PDF]
Nucleic Acids Res, 2021 Abstract Acquired drug resistance is a major obstacle in cancer therapy. Recent studies revealed that reprogramming of tRNA modifications modulates cancer survival in response to chemotherapy. However, dynamic changes in tRNA modification were not elucidated.
Pan Y, Yan TM, Wang JR, Jiang ZH.
europepmc +4 more sources
Lysophosphatidate induces chemo-resistance by releasing breast cancer cells from taxol-induced mitotic arrest. [PDF]
PLoS ONE, 2011 BackgroundTaxol is a microtubule stabilizing agent that arrests cells in mitosis leading to cell death. Taxol is widely used to treat breast cancer, but resistance occurs in 25-69% of patients and it is vital to understand how Taxol resistance develops ...
Nasser Samadi +4 more
doaj +2 more sources