Results 21 to 30 of about 2,363,919 (190)
Frontiers in Pharmacology, 2021 Ovarian cancer is the second most common gynecological malignancy, and one of the most deadly. The bottleneck restricting the treatment of ovarian cancer is its multi-drug resistance to chemotherapy.
Ming Sui +7 more
doaj +1 more source
Development of taxane resistance in a panel of human lung cancer cell lines [PDF]
, 2008 Using a selection process designed to reflect clinically relevant conditions, a panel of taxane-selected variants were developed to study further the mechanisms of resistance in lung cancer.
Keenan, Joanne +3 more
core +2 more sources
Upregulation of miR-129-5p increases the sensitivity to Taxol through inhibiting HMGB1-mediated cell autophagy in breast cancer MCF-7 cells [PDF]
Brazilian Journal of Medical and Biological ResearchAlthough Taxol has improved the survival of cancer patients as a first-line chemotherapeutic agent, an increasing number of patients develop resistance to Taxol after prolonged treatment.
Ying Shi +4 more
doaj +2 more sources
LINC00473 promotes the Taxol resistance via miR-15a in colorectal cancer. [PDF]
Biosci Rep, 2018 Dysregulation of long non-coding RNAs (LncRNAs) participated into the initiation and progression of different diseases via direct regulation of proteins or indirect regulation of microRNA (miRNA)-target genes. LINC00473 is a novel carcinoma-related LncRNA and up-regulated in many cancers for tumor growth and metastasis, but its role in chemotherapy ...
Wang L, Zhang X, Sheng L, Qiu C, Luo R.
europepmc +4 more sources
PLoS ONE, 2023 ObjectiveBreast cancer is the most common and high-incidence cancer in women. It is mainly treated by surgery combined with chemoradiation. The main challenge in treating breast cancer patients is developing resistance to chemotherapeutics, so it is ...
Weihua Gong +3 more
doaj +1 more source
European review for medical and pharmacological sciences, 2021 Nasopharyngeal carcinoma (NPC) is a common cancer with high incidence in Southern China. Taxol is one of the first-line chemotherapeutic drugs for treating NPC; however, Taxol resistance has become the main difficulty for clinical treatment and the mechanisms remain not fully understood. In this study, we mainly focus on exploring whether exosomes from
Yuan, F., Zhou, Z.-F.
openaire +2 more sources
Effects of taxol resistance gene 1 on the cisplatin response in gastric cancer. [PDF]
Oncol Lett, 2018 Cisplatin is used to treat multiple types of solid tumor, including gastric cancer. Although cisplatin initially exhibits good efficacy, therapeutic failure often occurs owing to the development of chemoresistance. To the best of our knowledge, the underlying mechanism of cisplatin resistance remains unknown.
Duan S, Yin J, Bai Z, Zhang Z.
europepmc +4 more sources
Convolvulus althaeoides as a Potential Natural Source in Cancer Prophylaxis and Treatment: LC-ESI-MS/MS, GC-MS, In Vitro, and In Silico Investigations. [PDF]
Chem Biodiversn‐hexane and EtOAc fractions of Convolvulus althaeoides aerial parts have potent cytotoxicity, significant antioxidant, and moderate anti‐inflammatory effects. These activities emphasize the potential role of this plant in cancer prophylaxis and treatment.
Hassan AR +4 more
europepmc +2 more sources
A Compressive Review about Taxol®: History and Future Challenges
Molecules, 2020 Taxol®, which is also known as paclitaxel, is a chemotherapeutic agent widely used to treat different cancers. Since the discovery of its antitumoral activity, Taxol® has been used to treat over one million patients, making it one of the most widely ...
Julia Gallego-Jara +4 more
doaj +1 more source
Perturbations in 3D genome organization can promote acquired drug resistance
Cell Reports, 2023 Summary: Acquired drug resistance is a major problem in the treatment of cancer. hTERT-immortalized, untransformed RPE-1 cells can acquire resistance to Taxol by derepressing the ABCB1 gene, encoding for the multidrug transporter P-gP.
Anna G. Manjón +17 more
doaj +1 more source