Results 11 to 20 of about 31,992 (181)
Production and Characterization of Taxol as Anticancer Agent from Aspergillus terreus [PDF]
Journal of Pure and Applied Microbiology, 2019 Taxol, a diterpenoid was initially isolated from the bark of Taxus brevifolia, approved by FDA in 1994 as a powerful drug for metastatic ovarian carcinoma, breast and lung cancer.
Ashraf S.A. El-Sayed +4 more
doaj +2 more sources
Enantioselective Total Synthesis of (−)-Taxol [PDF]
, 2016 Enantioselective total synthesis of taxol has been accomplished. Coupling reaction of the optically pure A-ring hydroxy aldehyde with the aromatic C-ring fragment followed by Lewis acid mediated eight-membered B-ring cyclization gave the desired ABC endo-
Nobuhito Nakamura (3005613) +7 more
core +1 more source
Frontiers in Plant Science, 2022 Taxol is a precious and effective anticancer drug. Cerium and methyl jasmonate (MJ) have been shown to increase the yield of taxol in taxus cells. However, the mechanisms of cerium-mediated and MJ-mediated taxol biosynthesis remain unknown.
Na Han +9 more
doaj +1 more source
Development of taxane resistance in a panel of human lung cancer cell lines [PDF]
, 2008 Using a selection process designed to reflect clinically relevant conditions, a panel of taxane-selected variants were developed to study further the mechanisms of resistance in lung cancer.
Keenan, Joanne +3 more
core +1 more source
Asymmetric Total Synthesis of Taxol [PDF]
, 2021 Taxol is one of the most famous natural diterpenoids and an important anticancer medicine. Taxol represents a formidable synthetic challenge and has prompted significant interest from the synthetic community.
Ya-Jian Hu +9 more
core +1 more source
Mdivi-1 induces spindle abnormalities and augments taxol cytotoxicity in MDA-MB-231 cells
Cell Death Discovery, 2021 Taxol is a first-line chemotherapeutic for numerous cancers, including the highly refractory triple-negative breast cancer (TNBC). However, it is often associated with toxic side effects and chemoresistance in breast cancer patients, which greatly limits
Chieh-Ting Fang +4 more
doaj +1 more source
Baseline survey of root-associated microbes of Taxus chinensis (Pilger) Rehd. [PDF]
PLoS ONE, 2015 Taxol (paclitaxel) a diterpenoid is one of the most effective anticancer drugs identified. Biosynthesis of taxol was considered restricted to the Taxus genera until Stierle et al.
Qian Zhang +7 more
doaj +1 more source
Molecules, 2021 Taxol is one of the most effective anticancer drugs in the world that is widely used in the treatments of breast, lung and ovarian cancer. The elucidation of the taxol biosynthetic pathway is the key to solve the problem of taxol supply.
Tao Wang +6 more
doaj +1 more source
Taxol-induced alteration of intracellular amino-acid profile related to human cervical carcinoma HeLa cell death [PDF]
, 2012 The anti-tumor action of Taxol was investigated in the changes of amino-acids involved in tumor cell survival. By tracing the intracellular amino-acid profiles of HeLa cells treated with non-conditioned and three conditioned media (Taxol, l-alanine, and ...
Wang, Long-Xing +5 more
core +1 more source
Mechanism-Based Rational Discovery and In Vitro Evaluation of Novel Microtubule Stabilizing Agents with Non-Taxol-Competitive Activity [PDF]
, 2020 Microtubules (MT) are cytoskeletal polymers of αβ-tubulin dimers that play a critical role in many cellular functions. Diverse antimitotic drugs bind to MT and disrupt their dynamics acting as MT stabilizing or destabilizing agents.
Matías Zúñiga-Bustos (7816295) +11 more
core +1 more source