Results 11 to 20 of about 31,972 (221)

Taxol acts differently on different tubulin isotypes [PDF]

Communications Biology, 2023
Taxol is a small molecule effector that allosterically locks tubulin into the microtubule lattice. We show here that taxol has different effects on different single-isotype microtubule lattices.
Yean Ming Chew, Robert A. Cross
doaj   +2 more sources

Production and Characterization of Taxol as Anticancer Agent from Aspergillus terreus

Journal of Pure and Applied Microbiology, 2019
Taxol, a diterpenoid was initially isolated from the bark of Taxus brevifolia, approved by FDA in 1994 as a powerful drug for metastatic ovarian carcinoma, breast and lung cancer.
Ashraf S.A. El-Sayed, Manal T. El Sayed, Hend S. Nada, Abdallah E. Hassan, Eman K. Yousef   +4 more
doaj   +2 more sources

Conjugation of Aspergillus flavipes Taxol with Porphyrin Increases the Anticancer Activity of Taxol and Ameliorates Its Cytotoxic Effects

Molecules, 2020
Taxol is one of the potential anticancer drugs; however, the yield of Taxol and its cytotoxicity are common challenges. Thus, manipulating the Taxol biosynthetic pathway from endophytic fungi, in addition to chemical modification with biocompatible ...
Ashraf S. A. El-Sayed, Maher Fathalla, Marwa A. Yassin, Nabila Zein, Shaima Morsy, Mahmoud Sitohy, Basel Sitohy   +6 more
doaj   +2 more sources

Production, bioprocess optimization and γ-irradiation of Penicillium polonicum, as a new Taxol producing endophyte from Ginko biloba

Biotechnology Reports (Amsterdam, Netherlands), 2021
Twenty-eight fungal endophytes were recovered from the different parts of Ginkgo biloba and screened for their Taxol producing potency. Among these isolates, Penicillium polonicum AUMC14487 was reported as the potent Taxol producer (90.53 μg/l).
Ahmed I El-Batal, Gamal M El-Sherbiny, Ashraf S A El-Sayed   +2 more
exaly   +3 more sources

Darkness: A Crucial Factor in Fungal Taxol Production

Frontiers in Microbiology, 2018
Fungal Taxol acquired lots of attention in the last few decades mainly because of the hope that fungi could be manipulated more easily than yew trees to scale up the production level of this valuable anticancer drug.
Sameh S. M. Soliman, Sameh S. M. Soliman, Sameh S. M. Soliman, Manish N. Raizada   +3 more
doaj   +2 more sources

Amesia nigricolor, a novel endophyte of Encephalartos bubalinus, exhibiting a robust taxol biosynthetic stability: chemical characterization and biological activities [PDF]

Microbial Cell Factories
Diminishing the productivity of Taxol by the potential fungi with storage is the key hurdle that impedes their applications to be an industrial platform for Taxol production.
Asmaa Gamal, Ashraf S. A. El-Sayed, Eman Fikry, Nora Tawfeek, Azza M. El-Shafae, Maher M. El-Domiaty   +5 more
doaj   +2 more sources

Taxol–DNA interactions: fluorescence and CD studies of DNA groove binding properties of taxol [PDF]

Biochimica Et Biophysica Acta - General Subjects, 1998
Taxol is perhaps the most successful drug used for the treatment of various cancers. Comprehensive literature accumulated on therapeutics of the drug has indicated numerous side effects.
Krishna N Ganesh
exaly   +2 more sources

Taxol®: The First Microtubule Stabilizing Agent

International Journal of Molecular Sciences, 2017
Taxol®, an antitumor drug with significant activity, is the first microtubule stabilizing agent described in the literature. This short review of the mechanism of action of Taxol® emphasizes the research done in the Horwitz’ laboratory.
Chia-Ping Huang Yang, Susan Band Horwitz
exaly   +2 more sources

Transcriptome-based signature predicts the effect of taxol in serous ovarian cancer. [PDF]

PLoS ONE, 2018
Taxol is a widely used chemotherapy drug used clinically for ovarian cancer, although the response to Taxol among individuals varies due to the heterogeneity among ovarian cancer patients. In this work, we analyzed differences in the prognostic effect of
Shunyu Hou, Jianrong Dai
doaj   +1 more source

Detection, Purification and Elucidation of Chemical Structure and Antiproliferative Activity of Taxol Produced by Penicillium chrysogenum

Molecules, 2020
Penicillium chrysogenum has been reported as a potent taxol producer based on quantitative analysis by TLC and HPLC. The biosynthetic potency of taxol has been validated from PCR detection of rate-limiting genes of taxol synthesis such as ...
Ashraf El-Sayed, Gamal Enan, Abdul-Raouf Al-Mohammadi, Ahmed H. Moustafa, Nashwa El-Gazzar   +4 more
doaj   +1 more source