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Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production

Metabolic Engineering, 2008
Metabolic engineering in microbes could be used to produce large amounts of valuable metabolites that are difficult to extract from their natural sources and too expensive or complex to produce by chemical synthesis. As a step towards the production of Taxol in the yeast Saccharomyces cerevisiae, we introduced heterologous genes encoding biosynthetic ...
Benedikt Engels, Stefan Jennewein
exaly   +4 more sources

Rewiring cellular metabolism for heterologous biosynthesis of Taxol

Natural Product Research, 2019
Taxol is one of the anticancer drugs synthesized naturally in the evergreen Taxus brevifolia forest tree belonging to the yew family (Taxaceae) growing on the Pacific. There are reportedly evidence for treating ovarian, breast and lung cancers through this drug given its unique structural and functional features.
Amirhossein Nazhand   +5 more
openaire   +4 more sources

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