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Key Step In Taxol Biosynthesis Revealed [PDF]
Chemical & Engineering News Archive, 2000 Four research groups, working collaboratively, have determined the remarkable single-step mechanism by which the acyclic compound geranylgeranyl diphosphate (GGPP) is converted biosynthetically into the tricyclic core of Bristol-Myers Squibb's anticancer agent Taxol (paclitaxel).
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Taxol: biosynthesis, molecular genetics, and biotechnological applications
Applied Microbiology and Biotechnology, 2001Over the past decade, Taxol and its closely related structural analogue Taxotere have emerged as very important antitumor agents. Their widespread use in the treatment of a variety of cancer types, their likely approval for the treatment of additional forms of cancer, and their use at earlier stages of intervention will lead to increased demand for ...
R Croteau, S Jennewein
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[Advances and prospects of taxol biosynthesis by endophytic fungi].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2016Taxol is one of the most important chemotherapeutic drugs against cancer. Taxol has been mainly extracted from the bark of yews for a long time. However, methods for the extraction of taxol from the bark of Taxus species were inefficient and environmentally costly.
Kai, Zhao +6 more
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Towards the biosynthesis of an alternative to Taxol
Molecular Medicine Today, 1998Kosan Biosciences (Burlingame, CA, USA) has received a Phase I Small Business Innovative Research Grant from the US National Cancer Institute to support their work on the biosynthetic pathway of the epothilones, a group of polyketides first isolated from the soil myxobacterium Sorangium cellulosum, as potential alternatives to the anticancer drug ...
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Oxetane Ring Formation in Taxol Biosynthesis Is Catalyzed by a Bifunctional Cytochrome P450 Enzyme
Journal of the American Chemical Society, 2023Taxol is a potent drug used in various cancer treatments. Its complex structure has prompted extensive research into its biosynthesis. However, certain critical steps, such as the formation of the oxetane ring, which is essential for its activity, have remained unclear.
Yong Zhao +9 more
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Researchers Probe Steps Of Taxol Biosynthesis
Chemical & Engineering News Archive, 1996Understanding detailed pathway could lead to improved cell culture techniques for production of potent anticancer drug Researchers are beginning to understand the detailed biosynthetic pathway by which yew plants produce the anticancer agent taxol. Their findings could lead to the development of a more efficient cell culture process for commercial ...
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Bioorganic & Medicinal Chemistry, 2001
Taxadiene, the key intermediate of paclitaxel (Taxol) biosynthesis, has been prepared enzymatically from isopentenyl diphosphate in cell-free extracts of Escherichia coli by overexpressing genes encoding isopentenyl diphosphate isomerase, geranylgeranyl diphosphate synthase and taxadiene synthase.
Rodney Croteau +3 more
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Taxadiene, the key intermediate of paclitaxel (Taxol) biosynthesis, has been prepared enzymatically from isopentenyl diphosphate in cell-free extracts of Escherichia coli by overexpressing genes encoding isopentenyl diphosphate isomerase, geranylgeranyl diphosphate synthase and taxadiene synthase.
Rodney Croteau +3 more
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Sites of biosynthesis and storage of Taxol in Taxus media (Rehder) plants: Mechanism of accumulation
Phytochemistry, 2020Taxol is a cytotoxic agent against various types of cancers. The cytotoxic activities of Taxol can be extended to its synthesizing plant. Here, Taxol is shown to have special synthesis, storage and transport mechanisms that avoid the toxic effects on its source plant.
Sameh S. M. Soliman +2 more
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Synthetic biology for Taxol biosynthesis and sustainable production
Trends in BiotechnologyIncomplete understanding of the biosynthetic pathway of the anticancer compound Taxol hinders its production by metabolic engineering. Recent reports by Jiang et al. and other groups now describe the missing steps in Taxol biosynthesis, notably including oxetane ring formation.
Linfeng Xie, Jiaoqi Gao, Yongjin J. Zhou
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Acting paths of elicitors on Taxol biosynthesis pathway and their synergistic effect
Biochemical Engineering Journal, 2002Many elicitors have been reported to be favorable to Taxol production in suspension cultures of Taxus cells. However, their acting paths were proved to be different, which were identified based on a quasi-steady-state transfer model. It was found that silver nitrate, ammonium citrate and methyl jasmonic acid acted on the path between Baccatin III and ...
Zuo-Jun Wei +3 more
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