Results 211 to 220 of about 10,148 (237)

Models for Taxol Biosynthesis: SeO₂Oxidation of Taxadiene

Synthetic Communications, 2006
Abstract Together with the expected mono‐oxidized taxa‐4(20),11(12)‐diene‐5‐ol (1) and taxa‐4(5),11,20‐diene‐20‐ol (2), a new taxane skeleton, 3,12‐cyclotaxane (3), was obtained from chemical oxidation of taxadiene by selenium dioxide/t‐butylhydroperoxide.
Howard J. Williams, James D. Pennington, Qiulong Huang, A. Ian Scott   +3 more
openaire   +2 more sources

Taxol® Biosynthesis and Production: From Forests to Fermenters

2017
Taxol® (paclitaxel) has fascinated researchers, medical professionals, politicians and entrepreneurs for almost half a century. Its medicinal value as a potent anti-cancer compound has expanded greatly over time as new applications have been identified for the treatment of diverse indications.
Stefan Jennewein, Christopher McElroy
openaire   +2 more sources

Mechanistic possibilities for oxetane formation in the biosynthesis of Taxol’s D ring

Russian Journal of General Chemistry, 2008
Three mechanistic possibilities for the formation of the oxetane (D ring) of Taxol were examined at various levels of theory [B3LYP/6-31+G(d,p), mPW1PW91/6-31+G(d,p), and MP2/6-31+G(d,p)] including one mechanism involving an unusual oxabicyclobutonium ion intermediate.
Dean J. Tantillo, Dan Willenbring
openaire   +2 more sources

Preliminary assessment of the C13-side chain 2′-hydroxylase involved in Taxol biosynthesis

Biochemical and Biophysical Research Communications, 2005
The biosynthesis of the anticancer drug Taxol in yew (Taxus) species is thought to involve the preliminary formation of the advanced taxane diterpenoid intermediate baccatin III upon which the functionally important N-benzoyl phenylisoserinoyl side chain is subsequently assembled at the C13-O-position.
Robert M. Long, Rodney Croteau
openaire   +3 more sources

[Advances of taxol combinatorial biosynthesis].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2015
Taxol is a kind of isoprenoid with strong anticancer activity. It is difficult to be obtained because of its low concentration in nature, which hinders its application in cancer treatment. Recently, biosynthesis methods for taxol production have attracted more attentions.
Jie, Li, Chunmei, Wang
openaire   +1 more source

Biosynthesis of Taxoids. Mode of Attachment of the Taxol Side Chain [PDF]

Journal of the American Chemical Society, 1994
Paul E. Fleming, Andrew R. Knaggs, Heinz G. Floss, Xian-Guo He, Ursula Mocek   +4 more
openaire   +1 more source

[Recent advances in the biosynthesis of Taxol].

Yao xue xue bao = Acta pharmaceutica Sinica, 2009
Taxol is one of the most potent chemotherapeutic agents known, showing excellent activity against a range of cancers. In addition to anticancer, taxol has the effect of preventing graft arteriosclerosis, antiscaring formation and inhibiting angiogenesis.
Jian-qiang, Kong, Wei, Wang, Ping, Zhu, Ke-di, Cheng   +3 more
openaire   +1 more source

Biosynthesis of Taxol

2021
Heinz G. Floss, Ursula Mocek
openaire   +1 more source

Asymmetric Total Synthesis of Taxol

Journal of the American Chemical Society, 2021
Ya-Jian Hu, Long Min, Chuang-Chuang Li
exaly  

Biosynthesis of taxoids. Mode of formation of the taxol side chain

Journal of the American Chemical Society, 1993
Paul E. Fleming, Ursula Mocek, Heinz G. Floss   +2 more
openaire   +2 more sources