Results 211 to 220 of about 327,793 (259)

Taxol® Biosynthesis and Production: From Forests to Fermenters

, 2018
Taxol® (paclitaxel) has fascinated researchers, medical professionals, politicians and entrepreneurs for almost half a century. Its medicinal value as a potent anti-cancer compound has expanded greatly over time as new applications have been identified for the treatment of diverse indications.
Christopher McElroy, S. Jennewein
semanticscholar   +2 more sources

ChemInform Abstract: Taxol Biosynthesis: An Update

ChemInform, 1997
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
M. HEZARI, R. CROTEAU
openaire   +1 more source

Role of an endodermis-specific miR858b-MYB1L module in the regulation of Taxol biosynthesis in Taxus mairei.

The Plant Journal
Taxol, a chemotherapeutic agent widely used for treating various cancers, is extracted from the stems of Taxus mairei. However, current knowledge regarding the effects of stem tissue and age on Taxol accumulation is limited.
Chunna Yu, Danjin Zhang, Lingxiao Zhang, Zijin Fang, Yibo Zhang, Wanting Lin, Ruoyun Ma, Mengyin Zheng, Enhui Bai, Chenjia Shen   +9 more
semanticscholar   +1 more source

Key Step In Taxol Biosynthesis Revealed

Chemical & Engineering News Archive, 2000
Four research groups, working collaboratively, have determined the remarkable single-step mechanism by which the acyclic compound geranylgeranyl diphosphate (GGPP) is converted biosynthetically into the tricyclic core of Bristol-Myers Squibb's anticancer agent Taxol (paclitaxel).
openaire   +1 more source

Researchers Probe Steps Of Taxol Biosynthesis

Chemical & Engineering News Archive, 1996
Understanding detailed pathway could lead to improved cell culture techniques for production of potent anticancer drug Researchers are beginning to understand the detailed biosynthetic pathway by which yew plants produce the anticancer agent taxol. Their findings could lead to the development of a more efficient cell culture process for commercial ...
openaire   +1 more source

[Advances of taxol combinatorial biosynthesis].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2015
Taxol is a kind of isoprenoid with strong anticancer activity. It is difficult to be obtained because of its low concentration in nature, which hinders its application in cancer treatment. Recently, biosynthesis methods for taxol production have attracted more attentions.
Jie, Li, Chunmei, Wang
openaire   +1 more source

Towards the biosynthesis of an alternative to Taxol

Molecular Medicine Today, 1998
Kosan Biosciences (Burlingame, CA, USA) has received a Phase I Small Business Innovative Research Grant from the US National Cancer Institute to support their work on the biosynthetic pathway of the epothilones, a group of polyketides first isolated from the soil myxobacterium Sorangium cellulosum, as potential alternatives to the anticancer drug ...
openaire   +1 more source

Models for Taxol Biosynthesis: SeO₂Oxidation of Taxadiene

Synthetic Communications, 2006
Abstract Together with the expected mono‐oxidized taxa‐4(20),11(12)‐diene‐5‐ol (1) and taxa‐4(5),11,20‐diene‐20‐ol (2), a new taxane skeleton, 3,12‐cyclotaxane (3), was obtained from chemical oxidation of taxadiene by selenium dioxide/t‐butylhydroperoxide.
Qiulong Huang, James D. Pennington, Howard J. Williams, A. Ian Scott   +3 more
openaire   +1 more source

Taxadiene Synthase purification and Molecular Characterization in Podocarpus elongatus EFBL-NZM for an Enhanced Taxadiene biosynthesis, a Key Taxol Biosynthetic Intermediate

Bulletin of Faculty of Science, Zagazig University
: The cyclization of geranylgeranyl diphosphate (GGPP) to diterpene taxadiene is carried out by Taxadiene synthase (TDS), one of the most effective rate-limiting enzymes for the production of taxol ...
Nabil Z. Mohamed, Lamis Shaaban, Samia Safan   +2 more
semanticscholar   +1 more source

Preliminary assessment of the C13-side chain 2′-hydroxylase involved in Taxol biosynthesis

Biochemical and Biophysical Research Communications, 2005
The biosynthesis of the anticancer drug Taxol in yew (Taxus) species is thought to involve the preliminary formation of the advanced taxane diterpenoid intermediate baccatin III upon which the functionally important N-benzoyl phenylisoserinoyl side chain is subsequently assembled at the C13-O-position.
Robert M, Long, Rodney, Croteau
openaire   +2 more sources