Results 131 to 140 of about 229,388 (307)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Ecological correlates of taxonomic and functional beta diversity of wetland breeding birds in central part of Inner Mongolia wetlands

Ecological Indicators
Wetlands in Inner Mongolia provide necessary habitats for many bird species and are considered important for biodiversity conservation. However, studies on spatial variation of bird communities within this region remain limited.
Ling-Ying Shuai, Yu-Xin Luo, Yue Luo, Jing-Wen Bai, Di Meng, Fu-Jia Sha, Ke Shi, Wan-Lan Ma, Fu-Shun Zhang   +8 more
doaj   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Response of Montane Fish Biodiversity to Landscape and Anthropogenic Activity Under Potential Water Quality Pathways

Ecology and Evolution
Mountain river ecosystems, globally recognized biodiversity hotspots shaped by pronounced landscape heterogeneity, are facing intensifying anthropogenic pressures.
Wenjun Zhong, Wanjuan Bi, Yan Zhang, Feilong Li, Zehua Zhang, Xiangyun Huang, Xunjie Liu, Yifan Wang, Song Zhang, Shan Xu, Loïc Pellissier, Xiaowei Zhang   +11 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Diversity of Curculionoidea in Humid Rain Forest Canopies of Borneo: A Taxonomic Blank Spot

, 2018
From 1992 to 2009, 334 trees were sampled by insecticidal knockdown on Borneo, Malaysia. Here, we describe the taxonomic composition of the 9671 specimens and 1589 species Curculionoidea collected (with additional notes on Cerambycidae).
Peter Sprick, Floren, Andreas, Andreas Floren, Sprick, Peter   +3 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Deterministic processes drive turnover-dominated beta diversity of breeding birds along the central Himalayan elevation gradient

Avian Research
Beta diversity, the variation of community composition among sites, bridges alpha and gamma diversity and can reveal the mechanisms of community assembly through applying distance-decay models and/or partitioning beta diversity into turnover and ...
Zhifeng Ding, Jianchao Liang, Le Yang, Cong Wei, Huijian Hu, Xingfeng Si   +5 more
doaj   +1 more source