Results 171 to 180 of about 229,388 (307)

The Impact of Urbanization on Taxonomic Diversity and Functional Similarity among Butterfly Communities in Waterfront Green Spaces. [PDF]

Insects, 2023
Fang W, Lin X, Lin Y, Huang S, Huang J, Fan S, Ran C, Dang E, Lin Y, Fu W.   +9 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Unraveling the Taxonomic Diversity and Functional Potential of the Tunisian Salterns, Abbassia and Thyna, via Integrated 16S-18S Amplicons and Shotgun Metagenomics. [PDF]

Int J Mol Sci
Mechri S, Najjari A, Croze S, Ouzari HI, Le Roes-Hill M, Tounsi S, Lachuer J, Jaouadi B.   +7 more
europepmc   +1 more source

High taxonomic diversity and miniaturization in benthic communities under persistent natural CO₂ disturbances. [PDF]

Proc Biol Sci, 2023
González-Delgado S, Wangensteen OS, Sangil C, Hernández CA, Alfonso B, Soto AZ, Pérez-Portela R, Mariani S, Hernández JC.   +8 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Phanerozoic Taxonomic Diversity: A Test of Alternate Models [PDF]

Science, 1973
openaire   +2 more sources

Taxonomic Diversity and Metabolic and Pharmacological Profiles of Marine-Derived Actinomycetes from the Lisbon and Setúbal Coast, Portugal. [PDF]

Mar Drugs
Coelho MP, Suárez-Moo P, Rocha M, Matos AOG, Marques V, Margarida S, Mil-Homens M, Prieto-Davó A, Rodrigues CMP, Bauermeister A, Sobral RG, Gaudêncio SP.   +11 more
europepmc   +1 more source

Terrestrial crustaceans (Arthropoda, Crustacea): taxonomic diversity, terrestrial adaptations, and ecological functions. [PDF]

Zookeys, 2023
Marin IN, Tiunov AV.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

DNA barcoding of <i>Messor</i> ants of Bulgaria with insights into their taxonomic diversity. [PDF]

Biodivers Data J
Lapeva-Gjonova A, Pramatarova M, Borowiec L, Gjonov I, Kostova R, Bekchiev R, Borissov S.   +6 more
europepmc   +1 more source