Results 161 to 170 of about 449,878 (299)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

High taxonomic diversity and miniaturization in benthic communities under persistent natural CO₂ disturbances. [PDF]

Proc Biol Sci, 2023
González-Delgado S, Wangensteen OS, Sangil C, Hernández CA, Alfonso B, Soto AZ, Pérez-Portela R, Mariani S, Hernández JC.   +8 more
europepmc   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Taxonomic Diversity and Metabolic and Pharmacological Profiles of Marine-Derived Actinomycetes from the Lisbon and Setúbal Coast, Portugal. [PDF]

Mar Drugs
Coelho MP, Suárez-Moo P, Rocha M, Matos AOG, Marques V, Margarida S, Mil-Homens M, Prieto-Davó A, Rodrigues CMP, Bauermeister A, Sobral RG, Gaudêncio SP.   +11 more
europepmc   +1 more source

Terrestrial crustaceans (Arthropoda, Crustacea): taxonomic diversity, terrestrial adaptations, and ecological functions. [PDF]

Zookeys, 2023
Marin IN, Tiunov AV.
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

DNA barcoding of <i>Messor</i> ants of Bulgaria with insights into their taxonomic diversity. [PDF]

Biodivers Data J
Lapeva-Gjonova A, Pramatarova M, Borowiec L, Gjonov I, Kostova R, Bekchiev R, Borissov S.   +6 more
europepmc   +1 more source

Taxonomic diversity of microbial communities in sub-seafloor hydrothermal sediments of the active Santorini-Kolumbo volcanic field. [PDF]

Front Microbiol, 2023
Polymenakou PN, Nomikou P, Hannington M, Petersen S, Kilias SP, Anastasiou TI, Papadimitriou V, Zaka E, Kristoffersen JB, Lampridou D, Wind S, Heinath V, Lange S, Magoulas A.   +13 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Taxonomic diversity in the global wheat phyllosphere mycobiome - a meta analysis. [PDF]

Front Plant Sci
Fischer MH, Rzepczynska A, Kjøller R.
europepmc   +1 more source