Results 161 to 170 of about 183,225 (261)

Functional diversity outperforms taxonomic diversity in revealing short-term trampling effects. [PDF]

Sci Rep, 2021
Li W, He S, Cheng X, Zhang M.
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Substrate type and palaeodepth do not affect the Middle Jurassic taxonomic diversity of crinoids. [PDF]

PeerJ, 2021
Salamon MA, Feldman-Olszewska A, Jain S, Ferré BBM, Paszcza K, Płachno BJ.   +5 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Taxonomic Diversity and Antimicrobial Potential of Thermophilic Bacteria from Two Extreme Algerian Hot Springs. [PDF]

Microorganisms
Aireche M, Merzoug M, Hammadi AI, Zater ZY, Bendida K, Brakna CN, Berrazeg M, Aireche AY, Saidi Y, Todorov SD, Arabet D, Saidi D.   +11 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Taxonomic diversity and functional potential of microbial communities in oyster calcifying fluid. [PDF]

Appl Environ Microbiol
Unzueta-Martínez A, Girguis PR.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Two New Species of <i>Lophozia</i> (Marchantiophyta) from the Sino-Himalaya and the Taxonomic Diversity of East Asian <i>Lophozia</i>. [PDF]

Plants (Basel)
Bakalin VA, Maltseva YD, Klimova KG, Ma W, Choi SS.   +4 more
europepmc   +1 more source

Chlamydiae in cnidarians: Shared functional potential despite broad taxonomic diversity

, 2023
Maire J, Collingro A, Horn M, van Oppen MJH.   +3 more
europepmc   +1 more source