Results 71 to 80 of about 174,907 (264)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Low functional β-diversity despite high taxonomic β-diversity among tropical estuarine fish communities.

PLoS ONE, 2012
The concept of β-diversity, defined as dissimilarity among communities, has been widely used to investigate biodiversity patterns and community assembly rules. However, in ecosystems with high taxonomic β-diversity, due to marked environmental gradients,
Sébastien Villéger, Julia Ramos Miranda, Domingo Flores Hernandez, David Mouillot   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Contrasting patterns of long-term zoobenthic diversity dynamics in response to sedimentary phosphorus input in eutrophic and mesotrophic lakes

Ecological Indicators
The response of ecosystem structures and functions to eutrophication has been investigated worldwide. Yet, present knowledge on the effects of nutrient inputs on biotic diversity is unsystematic and mainly based on taxonomic composition.
Yanmin Cao, Hui Li, Ziye Fu, Wenlong Ge, Xu Chen, Linghan Zeng, Enlou Zhang   +6 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The central role of soil in shaping terrestrial ferns’ assemblage composition, but not taxonomic diversity, in subtropical Atlantic forests [PDF]

Acta Botânica Brasílica
Understanding the uneven fern distribution is crucial for predicting future changes in their diversity and composition. Here, we explore major subtropical Atlantic Forest' physiognomies, addressing the following questions: 1) Is the current ...
Denilson da Silva Machado, Felipe Gonzatti, Leandro Duarte, Guilherme Dubal dos Santos Seger   +3 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Patterns and drivers of waterbird alpha and beta diversity are different between arid and humid regions of China

Avian Research
Waterbirds are vital for wetland ecosystems, but climate change and human activities are harming these habitats globally, reducing biodiversity and threatening waterbird survival. In China, wetlands in humid and arid regions face quite different threats,
Zhuoen Liu, Jinlei Zhang, Tingjia Zhao, Wenjian Song, Lu Wen, Qing Zhang, Gang Feng   +6 more
doaj   +1 more source