Results 131 to 140 of about 24,096 (164)

November 23-29, 2020 Residence TAZ to Service TAZ

2023
Travel time from TAZ of residence (origin) to Service TAZ (destination), measured for November 23-29 ...
CUERVO, Luis Gabriel, Cuervo, Daniel, Martínez-Herrera, Eliana, Molina, Ciro Jaramillo, Méndez, Jorge Gallego, Pinilla, Luis Fernando, Hatcher-Roberts, Janet   +6 more
openaire   +1 more source

Role of YAP/TAZ in mechanotransduction

Nature, 2011
Cells perceive their microenvironment not only through soluble signals but also through physical and mechanical cues, such as extracellular matrix (ECM) stiffness or confined adhesiveness. By mechanotransduction systems, cells translate these stimuli into biochemical signals controlling multiple aspects of cell behaviour, including growth ...
DUPONT, SIRIO, MORSUT, LEONARDO, ARAGONA, MARIACELESTE, ENZO, ELENA, GIULITTI, STEFANO, CORDENONSI, MICHELANGELO, ZANCONATO, FRANCESCA, Le Digabel J, Forcato M, Bicciato S, ELVASSORE, NICOLA, PICCOLO, STEFANO   +11 more
openaire   +3 more sources

TAZ is important for maintenance of the integrity of podocytes

American Journal of Physiology-Renal Physiology, 2022
Podocytes play an important role in maintaining the integrity of the structure and function of the kidney. We observed that mice with selective deletion of transcriptional coactivator with PDZ-binding motif (TAZ) in podocytes developed proteinuria. TAZ is constitutively active and critical for expression of synaptopodin, zonula occludens-1, and zonula
Jianchun Chen, Xiaoyong Wang, Qian He, Raymond C. Harris   +3 more
openaire   +2 more sources

TAZ promotes PDX1-mediated insulinogenesis

Cellular and Molecular Life Sciences, 2022
Transcriptional co-activator with PDZ-binding motif (TAZ) is a key mediator of the Hippo signaling pathway and regulates structural and functional homeostasis in various tissues. TAZ activation is associated with the development of pancreatic cancer in humans, but it is unclear whether TAZ directly affects the structure and function of the pancreas. So
Mi Gyeong Jeong, Hyo Kyeong Kim, Gibbeum Lee, Hee Yeon Won, Da Hye Yoon, Eun Sook Hwang   +5 more
openaire   +2 more sources

The emerging roles of YAP and TAZ in cancer [PDF]

Nature Reviews Cancer, 2015
Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) are the major downstream effectors of the Hippo pathway, which regulates tissue homeostasis, organ size, regeneration and tumorigenesis. In this Progress article, we summarize the current understanding of the biological functions of YAP and TAZ, and how the ...
Toshiro Moroishi, Carsten Gram Hansen, Kun-Liang Guan   +2 more
exaly   +5 more sources

BETting on YAP–TAZ

Nature Reviews Cancer, 2018
Two papers recently published in Nature Medicine and Science Signaling highlight the various interdependent or independent ways by which YAP and TAZ can affect tumour growth.
openaire   +2 more sources

YAP/TAZ phase separation for transcription

Nature Cell Biology, 2020
YAP and TAZ, paralogous mammalian genes, act as the key transcriptional effectors of the Hippo pathway. Two recent reports show that both YAP and TAZ form liquid–liquid phase-separated bodies that promote gene transcription by engaging in super-enhancers.
J. Matthew Franklin, Kun-Liang Guan
openaire   +2 more sources

Distinct effects of Hippo-YAP/TAZ and YAP/TAZ-TEAD in epithelial maintenance and repair

Biochemical and Biophysical Research Communications
The maintenance of epithelial homeostasis is essential for preserving tissue architecture and function, and the transcriptional co-activators YAP/TAZ are central to this regulatory network. Although the Hippo-YAP/TAZ-TEAD axis is known to govern epithelial integrity, it remains unclear to what extent Hippo-controlled YAP/TAZ activity overlaps with, or ...
Qiuyun Yuan, Yao Yuan, Yang Peng, Xiaoqiang Xia, Qianming Chen, Fa-Xing Yu, Xiaodong Feng   +6 more
openaire   +2 more sources

Spindle localization of YAP/TAZ maintains even distribution of YAP/TAZ in daughter cells

Journal of Biosciences
YAP and TAZ are downstream effectors of the Hippo signaling pathway, known to shuttle between the cytoplasm and nucleus, where they primarily function as transcriptional coactivators. Although their nuclear role has been well characterized, the non-transcriptional functions of YAP/TAZ remain poorly understood.
openaire   +2 more sources

“Down the Taz River to the Home of Mameyev” (From the History of the Development of the Taz Bay)

Herald of Omsk University. Series: Historical studies, 2019
The article first attempts to generalize information about the family of merchants and fish industrialists Mameyev, who lived on the coast of the Taz Bay in the second half of the 19th - first half of the 20th century. It is revealed that the first Mameyev settled there in 1863. In the late 19th century, along with other industrialists who set up their
openaire   +1 more source