Results 121 to 130 of about 76,145 (237)

Collateral susceptibility-guided alternation of ceftolozane/tazobactam with imipenem prevents resistance development in XDR Pseudomonas aeruginosa biofilms

open access: yesBiofilm
Objectives: New combinations of β-lactams and β-lactamase inhibitors, such as ceftolozane/tazobactam could be useful to combat biofilm-driven chronic infections by extensively resistant (XDR) Pseudomonas aeruginosa but resistance development by mutations
María Fernández-Billón   +9 more
doaj   +1 more source

Application of Metagenomic Next‐Generation Sequencing in the Diagnosis of Pneumonia in Patients With Cancer

open access: yesCancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background With the development of new sequencing technologies, metagenomic next‐generation sequencing (mNGS) has become a diagnostic tool for respiratory tract infections. Patients with cancer may develop pneumonia caused by infections or antitumor therapy.
Rong Qin   +4 more
wiley   +1 more source

Optimizing Vancomycin Dosing in Chronic Kidney Disease by Deriving and Implementing a Web-Based Tool Using a Population Pharmacokinetics Analysis. [PDF]

open access: yes, 2019
Background: Chronic kidney disease (CKD) patients requiring intravenous vancomycin bear considerable risks of adverse outcomes both from the infection and vancomycin therapy itself, necessitating especially precise dosing to avoid sub- and ...
Chae, Jung-Woo   +9 more
core  

Severe Adult HLH/MAS With SPTCL‐Like Panniculitis: A Phenotype‐Guided, Resource‐Adapted Therapeutic Strategy Without Cytotoxic Therapy

open access: yesClinical Case Reports, Volume 14, Issue 5, May 2026.
Graphical abstract illustrating the phenotype‐guided therapeutic approach in severe adult HLH/MAS with SPTCL‐like panniculitis, demonstrating clinical and biochemical response following sequential treatment with therapeutic plasma exchange, intravenous immunoglobulin, and cyclosporine.
Hatem Mousa Taha   +2 more
wiley   +1 more source

Piperacillin/Tazobactam as Cause of Acute Generalized Exanthematous Pustulosis

open access: yesCase Reports in Dermatological Medicine, 2019
Acute generalized exanthematous pustulosis (AGEP) is a rare cutaneous adverse reaction mainly attributed to antibiotics. It is characterized by numerous, nonfollicular, sterile pustules, arising on an exanthematous and edematous base.
Aikaterini Kyriakou   +4 more
doaj   +1 more source

Mortality after broad‐ versus narrow‐spectrum antibiotic treatment for patients with nursing and healthcare‐associated pneumonia: A nationwide retrospective cohort study

open access: yesJournal of Hospital Medicine, Volume 21, Issue 5, Page 477-486, May 2026.
Visual Abstract Abstract Background Nursing and healthcare‐associated pneumonia (NHCAP) is defined as pneumonia occurring in individuals with frequent healthcare contact, such as residents of care facilities or patients with impaired activities of daily living.
Jumpei Taniguchi   +4 more
wiley   +1 more source

Orbital Complications of Acute Rhinosinusitis in Adulthood: Predictors of Outcome and Management

open access: yesThe Laryngoscope, Volume 136, Issue 5, Page 2073-2081, May 2026.
In a multicenter cohort of 213 adults with orbital complications of acute rhinosinusitis, 68% required surgery and the modified Chandler classification was the strongest predictor of treatment modality. While abscess‐related and type II complications frequently necessitated surgical management, final ophthalmologic outcomes were uniformly favorable ...
Alessandro Vinciguerra   +41 more
wiley   +1 more source

Laryngeal Transplantation in Cancer Patients: Evaluation of Surgical Outcomes and Functional Recovery

open access: yesMedComm, Volume 7, Issue 5, May 2026.
Our pilot clinical study in laryngeal transplantation achieved divergent outcomes: two cases maintained functional speech/swallowing with around 2 year graft survival and have been ongoing, while two succumbed to sepsis (10mo) and hemorrhagic recurrence (11mo).
Zheng Jiang   +9 more
wiley   +1 more source

Emergence and Genomic Characterization of a Hypervirulent Klebsiella pneumoniae Isolate From a New Clone in Brazil

open access: yesMicrobiology and Immunology, Volume 70, Issue 5, Page 261-267, May 2026.
ABSTRACT Hypervirulent Klebsiella pneumoniae (hvKp) has emerged globally as a major public health concern, often associated with severe community‐acquired and healthcare‐associated human infections. Despite alerts from PAHO/WHO on convergent hvKp strains with multidrug resistance in Latin America, comprehensive data from Brazil, the region's largest ...
Carlos Henrique Camargo   +21 more
wiley   +1 more source

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