Results 1 to 10 of about 52,056 (152)

Piperacillin–tazobactam tolerability in patients with a labeled penicillin allergy (PIPPEN) [PDF]

Antimicrobial Stewardship & Healthcare Epidemiology
Background: Piperacillin–tazobactam is a beta-lactam antibiotic with a distinct R1 side chain compared to other penicillins, therefore the risk of cross-reactivity should be theoretically low.
Avneet Purewal, Kieran Shah, Sarah N. Stabler, Kevin Afra, Ke Su   +4 more
doaj   +2 more sources

Ensuring Sufficient Trough Plasma Concentrations for Broad-Spectrum Beta-Lactam Antibiotics in Children With Malignancies: Beware of Augmented Renal Clearance!

Frontiers in Pediatrics, 2022
Introduction: Broad-spectrum beta-lactams are commonly prescribed for empirical or selective treatment of bacterial infections in children with malignancies.
Pascal André, Léonore Diezi, Kim Dao, Pierre Alex Crisinel, Laura E. Rothuizen, Haithem Chtioui, Laurent Arthur Decosterd, Manuel Diezi, Sandra Asner, Thierry Buclin   +9 more
doaj   +1 more source

Semirapid Detection of Piperacillin/Tazobactam Resistance and Extended-Spectrum Resistance to β-Lactams/β-Lactamase Inhibitors in Clinical Isolates of Escherichia coli

Microbiology Spectrum, 2021
Piperacillin/tazobactam (TZP) is a β-lactam/β-lactamase inhibitor (BL/BLI) recommended for the empirical treatment of severe infections. The excessive and indiscriminate use of TZP has promoted the emergence of TZP-resistant Escherichia coli isolates ...
Ángel Rodríguez-Villodres, Alicia Gutiérrez Linares, Lydia Gálvez-Benitez, Jerónimo Pachón, José Antonio Lepe, Younes Smani   +5 more
doaj   +1 more source

Antimicrobial activity of high-dose cefepime-tazobactam (WCK 4282) against a large collection of gram-negative organisms collected worldwide in 2018 and 2019

International Journal of Infectious Diseases, 2022
: Background: High-dose cefepime-tazobactam (WCK 4282) is currently under clinical development at a dosage of 2 grams/2 grams every 8 hours with prolonged infusion (90 minutes).
Helio S. Sader, Cecilia G. Carvalhaes, Rodrigo E. Mendes, Mariana Castanheira   +3 more
doaj   +1 more source

Development and validation of a quantitative HPLC/MS/MS method for the determination of piperacillin in blood plasma

Research Results in Pharmacology, 2023
Introduction: Reduced mortality in patients with sepsis taking piperacillin is possible when they receive a long-term infusion, which improves the effect of antimicrobials.
Vladimir I. Petrov, Ivan S. Anikeev, Tatyana E. Zayachnikova, Andrey V. Strygin, Anna M. Dotsenko   +4 more
doaj   +1 more source

Analysis of IV Drugs in the Hospital Workflow by Raman Spectroscopy: The Case of Piperacillin and Tazobactam

Molecules, 2021
Medical errors associated with IV preparation and administration procedures in a hospital workflow can even cost human lives due to the direct effect they have on patients.
Ioanna Chrisikou, Malvina Orkoula, Christos Kontoyannis   +2 more
doaj   +1 more source

Piperacillin Steady State Concentrations in Target Tissues Relevant for PJI Treatment—A Randomized Porcine Microdialysis Study Comparing Continuous Infusion with Intermittent Short-Term Infusion

Antibiotics, 2023
(1) Introduction: Piperacillin is a common antibiotic choice in the treatment of periprosthetic joint infections (PJI) caused by Pseudomonas aeruginosa.
Hans Christian Rasmussen, Pelle Hanberg, Martin Knudsen, Sara Kousgaard Tøstesen, Andrea René Jørgensen, Elisabeth Krogsgaard Petersen, Kristina Öbrink-Hansen, Kjeld Søballe, Maiken Stilling, Mats Bue   +9 more
doaj   +1 more source

Continuous infusion of piperacillin‐tazobactam significantly improves target attainment in children with cancer and fever

Cancer Reports, 2022
Background Children with febrile neutropenia commonly exhibit alterations of pharmacokinetic (PK) parameters, leading to decreased β‐lactam concentrations.
Sabine F. Maarbjerg, Anders Thorsted, Lena E. Friberg, Elisabet I. Nielsen, Mikala Wang, Henrik Schrøder, Birgitte K. Albertsen   +6 more
doaj   +1 more source

Population Pharmacokinetic Model of Piperacillin in Critically Ill Patients and Describing Interethnic Variation Using External Validation

Antibiotics, 2022
Objectives: This study aimed to develop a piperacillin population PK model for critically ill Brazil-ian patients and describe interethnic variation using an external validation. Methods: Plasma samples were obtained from 24 ICU patients during the fifth
Cristina Sanches, Geisa C. S. Alves, Andras Farkas, Samuel Dutra da Silva, Whocely Victor de Castro, Farah Maria Drummond Chequer, Francisco Beraldi-Magalhães, Igor Rafael dos Santos Magalhães, André de Oliveira Baldoni, Mark D. Chatfield, Jeffrey Lipman, Jason A. Roberts, Suzanne L. Parker   +12 more
doaj   +1 more source

Therapeutic Drug Monitoring of Meropenem and Piperacillin in Critical Illness—Experience and Recommendations from One Year in Routine Clinical Practice

Antibiotics, 2020
Various studies have reported insufficient beta-lactam concentrations in critically ill patients. The extent to which therapeutic drug monitoring (TDM) in clinical practice can reduce insufficient antibiotic concentrations is an ongoing matter of ...
Christina Scharf, Michael Paal, Ines Schroeder, Michael Vogeser, Rika Draenert, Michael Irlbeck, Michael Zoller, Uwe Liebchen   +7 more
doaj   +1 more source