Results 1 to 10 of about 4,295 (159)

Penicillanic Acid Sulfones Inactivate the Extended-Spectrum β-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of β-Lactamase Inhibition [PDF]

mBio, 2022
β-Lactamases hydrolyze β-lactam antibiotics and are major determinants of antibiotic resistance in Gram-negative pathogens. Enmetazobactam (formerly AAI101) and tazobactam are penicillanic acid sulfone (PAS) β-lactamase inhibitors that differ by an ...
Philip Hinchliffe, Catherine L. Tooke, Christopher R. Bethel, Benlian Wang, Christopher Arthur, Kate J. Heesom, Stuart Shapiro, Daniela M. Schlatzer, Krisztina M. Papp-Wallace, Robert A. Bonomo, James Spencer   +10 more
doaj   +2 more sources

Molecular docking of human serum albumin with penicillin G determinants [PDF]

Біофізичний вісник, 2023
Background: Human serum albumin (HSA) is the main pharmacokinetic effector of many medications, including penicillin G and its metabolites. An urgent problem of practical medicine is immediate hypersensitivity reactions caused by penicillin toxicity ...
N. V. Khmil, V. G. Kolesnikov
doaj   +3 more sources

Microwave-assisted synthesis of some hybrid molecules containing penicillanic acid or cephalosporanic acid moieties and investigation of their biological activities. [PDF]

Med Chem Res, 2014
Alpay Karaoglu, Sengul/0000-0003-1047-8350WOS: 000334184400039Ethyl 4-amino-2-fluorophenylpiperazin-1-carboxylates containing a 1,3-oxazol(idin)e, 5-thioxo-1,2,4-triazole, 1,3,4-thiadiazole, 5-thioxo-1,3,4-oxadiazole, or 1,3-thiazole nucleus were ...
Basoglu S, Ulker S, Alpay-Karaoglu S, Demirbas N.   +3 more
europepmc   +3 more sources

Regiospecific syntheses of 6alpha-(1R-Hydroxyoctyl)penicillanic acid and 6beta-(1R-hydroxyoctyl)penicillanic acid as mechanistic probes of class D beta-lactamases. [PDF]

Org Lett, 2009
The unique hydrophobic surface patches in class D beta-lactamases presented an opportunity for designing two compounds, 6alpha-(1R-hydroxyoctyl)penicillanic acid and 6beta-(1R-hydroxyoctyl)penicillanic acid, as mechanistic probes of these enzymes. In a sequence of three synthetic steps from benzhydryl 6,6-dibromopenicillanate, the targeted compounds ...
Testero SA, O'Daniel PI, Shi Q, Lee M, Hesek D, Ishiwata A, Noll BC, Mobashery S.   +7 more
europepmc   +4 more sources

Self-Assembly of Alginate-Grafted Penicillanic Acid Derivatives into Antibacterial Micelles for Controlled Drug Delivery [PDF]

ACS Omega
Xiuqiong Chen, Jiayi Liu, Jiji Fan, Yanan Bu, Qian Wang, Huiqiong Yan, Changjiang Yu, Qiang Lin   +7 more
doaj   +2 more sources

Targeting Class A and C Serine \u3b2-Lactamases with a Broad-Spectrum Boronic Acid Derivative [PDF]

, 2014
Production of \u3b2-lactamases (BLs) is the most widespread resistance mechanism adopted by bacteria to fight \u3b2-lactam antibiotics. The substrate spectrum of BLs has become increasingly broad, posing a serious health problem. Thus, there is an urgent
Alberto Venturelli, Bebrone C., Bennett P. M., Blizzard T. A., Bonnefoy A., Bonnet R., Bradshaw J. M., Brian K. Shoichet, Brunger A. T., Bush K., Bush K., Carter P. J., Cecilia Pozzi, Chaibi E. B., Chen Y., Chen Y., Coleman K., Delmas J., Donatella Tondi, Drawz S. M., Ehmann D. E., Emsley P., Farina D., Hirsch E. B., Hunter C. A., Ibuka A., Jacoby G. A., Kettner C. A., Laskowski R. A., Lovell S. C., Majumdar S., Marciano D. C., Maria Paola Costi, Morandi F., Murshudov G. N., Ness S., Nichols D. A., Otwinowski Z. M., Pages J. M., Potterton E., Powers R. A., Powers R. A., Richard Bonnet, Robin F., Roth T. A., Strynadka N. C., Strynadka N. C. J., Strynadka N. C. J., Thornton J. M., Tondi D., Tondi D., Usher K., Venturelli A., Waley S. G., Wang X., Wang X., Wang X., Willcockson I. U., Winn M. D.   +58 more
core   +6 more sources

Synthesis and biological activity study of some novel Tri-Schiff’s basses derived from 6-aminopenicillanic acid and Tri-amide containing three 1,3,4-thiadiazole units.

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2009
Reaction of meistylene with bromine under UV-light afforded α,α,α',α',α",α"-hexabromo mesitylene [2]. The reaction of compound [2] with morpholine and hydrochloric acid afforded 1,3,5-triformyl benzene [3].
Radwan M. Ali Hameed
doaj   +1 more source

Preparation and characterization of cadmium (ll), zinc (ll) and copper (ll) ion complexes using new triazene ligands and study of their biological activity [PDF]

Caspian Journal of Environmental Sciences
The synthesis of novel ligand was disclosed in this study. This ligand was synthesized from reaction between 4-amino anti pyrene and 6-amino penicillanic acid by triazene reaction.
Haneen Sadi Hussein, Mohammad Hamid Said, Ahmed Hassan Shantaf   +2 more
doaj   +1 more source

Simple, Quick Methods for Detection of 6-Amino-penicillanic Acid [PDF]

Nature, 1961
ONE of the greatest discoveries of the past years in penicillin research was the discovery, isolation1 and preparation of 6-amino-penicillanic acid (6-APA) forming the common ‘nucleus’ of natural penicillins2,3, and the successful introduction into therapy of semi-synthetic penicillins produced from it4,5. The new semi-synthetic penicillin preparations
J, URI, F, SZTARICSKAI
openaire   +2 more sources

Production of 6-aminopenicillanic acid in aqueous two-phase systems by recombinant Escherichia coli with intracellular penicillin acylase [PDF]

, 2004
Bioconversion of Penicillin G in PEG 20000-Dextran T 70 aqueous two-phase systems was achieved using the recombinant Escherichia coli A56 (ppA22) with intracellular penicillin acylase as catalyst. The best conversion conditions were attained for: 7%(w/v)
Cabral, J. M. S., Cao, Xue-jun, Fonseca, Luís Pina, Marcos, João Carlos, Wu, Xing-yan   +4 more
core   +1 more source