Results 11 to 20 of about 4,314 (176)

Mechanistic basis for inhibition of the extended-spectrum β-lactamase GES-1 by enmetazobactam and tazobactam. [PDF]

FEBS Lett
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Beer M, Hinchliffe P, Hanževački M, Bethel CR, Tooke CL, Van der Kamp MW, Papp-Wallace KM, Bonomo RA, Shapiro S, Mulholland AJ, Spencer J.   +10 more
europepmc   +2 more sources

Transesterification of Non‐Activated Esters Promoted by Small Molecules Mimicking the Active Site of Hydrolases

Angewandte Chemie, Volume 134, Issue 35, August 26, 2022., 2022
A small artificial hydrolase that mimics the active centre of chymotrypsin and N‐terminal hydrolases is able to perform, for the first time, the transesterification of ethyl acetate with methanol under neutral conditions and at room temperature. This artificial enzyme also catalysed the transesterification of important neurotransmitter acetylcholine ...
José J. Garrido‐González, Estela Sánchez‐Santos, Asmaa Habib, Ángel V. Cuevas Ferreras, Francisca Sanz, Joaquín R. Morán, Ángel L. Fuentes de Arriba   +6 more
wiley   +2 more sources

Increasing the Selectivity of Light‐Active Antimicrobial Agents – Or How To Get a Photosensitizer to the Desired Target

ChemBioChem, Volume 24, Issue 18, September 15, 2023., 2023
Selective targeting of light‐active molecules to pathogens is a very attractive approach in modern drug discovery efforts. In this review, we summarize the current developments and highlights of recent literature dealing with the modification of photosensitizers to increase their target specificity.
Michael Grimmeisen, Claudia Jessen‐Trefzer   +1 more
wiley   +1 more source

International consensus recommendations for the use of prolonged‐infusion beta‐lactam antibiotics: Endorsed by the American College of Clinical Pharmacy, British Society for Antimicrobial Chemotherapy, Cystic Fibrosis Foundation, European Society of Clinical Microbiology and Infectious Diseases, Infectious Diseases Society of America, Society of Critical Care Medicine, and Society of Infectious Diseases Pharmacists

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 43, Issue 8, Page 740-777, August 2023., 2023
Abstract Intravenous β‐lactam antibiotics remain a cornerstone in the management of bacterial infections due to their broad spectrum of activity and excellent tolerability. β‐lactams are well established to display time‐dependent bactericidal activity, where reductions in bacterial burden are directly associated with the time that free drug ...
Lisa T. Hong, Kevin J. Downes, Alireza FakhriRavari, Jacinda C. Abdul‐Mutakabbir, Joseph L. Kuti, Sarah Jorgensen, David C. Young, Mohammad H. Alshaer, Matteo Bassetti, Robert A. Bonomo, Mark Gilchrist, Soo Min Jang, Thomas Lodise, Jason A. Roberts, Thomas Tängdén, Athena Zuppa, Marc H. Scheetz   +16 more
wiley   +1 more source

Antibiotics “dumped”: Negotiating Pharmaceutical Identities, Properties, and Interests in China–India Trade Disputes

Medical Anthropology Quarterly, Volume 37, Issue 2, Page 148-163, June 2023., 2023
Abstract China and India have become major producers of antibiotics, and the world has become highly dependent on them. Since 2000, the competition among Chinese and Indian manufacturers on key antibiotic ingredients has become increasingly intense in a series of trade disputes involving anti‐dumping investigations.
Mingyuan Zhang, Lise Bjerke
wiley   +1 more source

Bio‐Inspired Imprinting Materials for Biomedical Applications

Advanced Science, Volume 9, Issue 28, October 5, 2022., 2022
Inspired by the recognition mechanism of biological molecules, molecular imprinting techniques are imparted with numerous merits and thus broaden the avenues for convenient fabrication protocol of bio‐inspired molecularly imprinted polymers with desirable functions to satisfy the extensive demands of biomedical applications. Herein, the recent research
Hanxu Chen, Jiahui Guo, Yu Wang, Weiliang Dong, Yuanjin Zhao, Lingyun Sun   +5 more
wiley   +1 more source

Kinetics and Mechanism of Oxidation of Carbenicillin by Copper (III) Periodate Complex in Aqueous Alkaline Medium

Journal of Chemistry, Volume 2020, Issue 1, 2020., 2020
Kinetics and mechanism of oxidation of carbenicillin by diperiodatocuprate [DPC‐III] in aqueous alkaline medium were studied spectrophotometrically at 298 K and an ionic strength of 0.10 mol·dm−3. The reaction between DPC (III) and carbenicillin in the alkaline medium showed (CRBC : DPC‐III) 1 : 4 stoichiometry. The reaction products were identified by
Yuv Raj Sahu, Parashuram Mishra, Leonardo Palmisano   +2 more
wiley   +1 more source

Comparison between a direct-flow SPR immunosensor for ampicillin and a competitive conventional amperometric device: analytical features and possible applications to real samples [PDF]

, 2017
In this research, we developed a direct-flow surface plasmon resonance (SPR) immunosensor for ampicillin to perform direct, simple, and fast measurements of this important antibiotic.
Campanella, Luigi, Favero, Gabriele, Martini, Elisabetta, Mazzei, Franco, Merola, Giovanni, Sanzo', Gabriella, Tomassetti, Mauro   +6 more
core   +2 more sources

Antibiotics for acute bronchitis. [PDF]

, 2014
BACKGROUND: The benefits and risks of antibiotics for acute bronchitis remain unclear despite it being one of the most common illnesses seen in primary care.
Ayres, Batieha, Becker, Boldy, Brickfield, Butler, Chalmers, Christ-Crain, Coenen, Dagnelie, Delozier, Dowell, Dunlay, Evans, Fahey, Fahey, Falck, Foy, Franks, Gonzales, Gonzales, Gordon, Gottfarb, Grayston, Gulliford, Henry, Herman, Herwaldt, Howie, Hueston, Hueston, Jonsson, Kaiser, King, Laurenzi, Lefebvre, Little, Little, Llor, Macfarlane, Macfarlane, Macfarlane, Macfarlane, Mainous, Matthys, Metlay, Metlay, Meza, Molstad, Nduba, Oeffinger, Petersen, Robertson, Scherl, Smith, Smith, Smith, Smucny, Smucny, Stott, Straand, Stuart-Harris, Thom, Velden, Verheij, Verheij, Williamson   +66 more
core   +1 more source

Inverted sugar syrup attained from sucrose hydrolysis using a membrane reactor [PDF]

, 2010
Invertase, whether adsorbed on styrene-divinylbenzene copolymers or otherwise, was used for continuous sucrose hydrolysis using a cell-type membrane reactor (CTMR), coupled with an ultra (UF-100kDa), or a microfiltration (MF- pore diameter of 5 µm ...
TOMOTANI, Ester Junko, VITOLO, Michele
core   +4 more sources