The action of "Penbritin" on Brucella micro-organism [PDF]
, 1962 A report (Rolinson and Stevens, 1961) on 6 D aminophenylacetamido penicillanic acid Penbdtin and its action on Gram-negative bacteria made us think it would be useful to test its activity on Brucella micro-organisms.
Agius, Emanuel, Mifsud, Joseph
core
Cross-class metallo-β-lactamase inhibition by bisthiazolidines reveals multiple binding modes [PDF]
, 2016 Metallo-β-lactamases (MBLs) hydrolyze almost all β-lactam antibiotics and are unaffected by clinically available β-lactamase inhibitors (βLIs). Active-site architecture divides MBLs into three classes (B1, B2, and B3), complicating development of βLIs ...
Bonomo, Robert A. +12 more
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Antimicrobial Activity of Ceftolozane-Tazobactam Tested against Enterobacteriaceae and Pseudomonas aeruginosa with Various Resistance Patterns Isolated in U.S. Hospitals (2011-2012) [PDF]
, 2013 Ceftolozane/tazobactam, a novel antimicrobial agent with activity against Pseudomonas aeruginosa (including drug-resistant strains) and other common Gram-negative pathogens (including most extended-spectrum-beta-lactamase [ESBL]-producing ...
Farrell, David J. +3 more
core +2 more sources
Archiv der Pharmazie, 2013 6‐Substituted amino‐penicillanic acid esters were synthesized starting with 6‐apa. The compounds containing a 1,3‐thiazole‐ or 1,3‐thiazolidinone nucleus linked to the penicillanic acid skeleton via a hydrazino linkage were obtained from 6‐apa. The treatment of carbonylamino and carbonothioylamino compounds with 4‐chlorophenacyl bromide or ethyl ...
Demirci, Serpil +4 more
openaire +3 more sources
Interaction of Staphylococcal Penicillinase and 6-[D(—)-α-Guanidino-Phenylacetamido]-Penicillanic Acid [PDF]
Applied Microbiology, 1968 6[ d (—)-α-Guanidinophenylacetamido]-penicillanic acid was shown to be significantly hydrolyzed by only one of six preparations of staphylococcal penicillinase. This penicillin analogue is a stronger penicillinase inactivator than are nafcillin and methicillin, which were not significantly ...
E H, Thiele, H J, Robinson
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Site-saturation studies of β-lactamase: Production and characterization of mutant β-lactamases with all possible amino acid substitutions at residue 71 [PDF]
, 1986 A mutagenic technique that "saturates" a particular site in a protein with all possible amino acid substitutions was used to study the role of residue 71 in β-lactamase (EC 3.5.2.6). Threonine is conserved at residue 71 in all class A β-lactamases and is
Richards, John H., Schultz, Steve C.
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Activity of OP0595-β-lactam combination against Gram-negative bacteria with extended-spectrum, AmpC and carbapenem-hydrolysing β-lactama [PDF]
, 2015 Background: OP0595 is a diazabicyclooctane that (i) acts as a PBP2-ctive antibacterial, (ii) inhibits Class A and C β-lactamases and (iii), like mecillinam, gives β-lactamase-independent potentiation of β-lactams targeting other PBPs.
Livermore, David M. +3 more
core +1 more source
A novel synthetic method for penicillanic acid derivatives by electroreduction.
Chemical and Pharmaceutical Bulletin, 1988 Electroreductive dehalogenation of 6-halopenicillanic acid derivatives was conveniently carried out to give the corresponding penicillanic acid derivatives, key intermediates in syntheses of various β-lactamase inhibitors, in good yields.
S, Ikeda +3 more
openaire +3 more sources
, 2014 The OXA β-lactamases were among the earliest β-lactamases detected; however, these molecular class D β-lactamases were originally relatively rare and always plasmid mediated.
Brink AJ +5 more
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A Reaction Database for Small Molecule Pharmaceutical Processes Integrated with Process Information [PDF]
, 2017 This article describes the development of a reaction database with the objective to collect data for multiphase reactions involved in small molecule pharmaceutical processes with a search engine to retrieve necessary data in investigations of reaction ...
Anantpinijwatna, Amata +3 more
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