Results 61 to 70 of about 238,637 (182)

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Strengthening accountability for tuberculosis policy implementation in South Africa: perspectives from policymakers, civil society, and communities

BMC Global and Public Health
Background Translating health policy into effective implementation is a core priority for responding effectively to the tuberculosis (TB) crisis. The national TB Recovery Plan was developed in response to the negative impact that the COVID-19 pandemic ...
Helene-Mari van der Westhuizen, Janet Giddy, Renier Coetzee, Goodman Makanda, Phumeza Tisile, Michelle Galloway, Siyavuya Bunyula, Ingrid Schoeman, Ruvandhi R. Nathavitharana   +8 more
doaj   +1 more source

Assessment of Isoniazid Preventive Therapy Outcome Among People Living with HIV in a Referral Hospital, Northeast Ethiopia

Integrated Pharmacy Research and Practice, 2020
Yohannes Mengesha,1 Muhammed Ahmed2 1Department of Pharmacy, Pharmaceutics Unit, Wollo University, College of Medicine and Health Sciences, Dessie, Ethiopia; 2Dessie Referral Hospital, Dessie, EthiopiaCorrespondence: Yohannes Mengesha Email joymengesha ...
Mengesha Y, Ahmed M
doaj  

Ugonjwa wa TB inayosababisha madhara

, 2016
Title from PDF caption (viewed on December 13, 2017)."Imetokana na maelezo ya Mradi wa Kuzuia na Kudhibiti TB wa Idara ya Afya ya Minnesota.""SW OHA 8346 (3/2016)."This archived document is maintained by the State Library of Oregon as part of the Oregon ...

core  

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Missed Tuberculosis Investigations and Associated Factors in Patients with Symptoms Indicative of Tuberculosis at Public Health Institutions in Northwest Ethiopia: The Application of a Negative Binomial Model

Infection and Drug Resistance, 2022
Mulusew Andualem Asemahagn School of Public Health, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, EthiopiaCorrespondence: Mulusew Andualem Asemahagn, Email muler.hi@gmail.comBackground: Tuberculosis (TB) remains one of the top
Asemahagn MA
doaj  

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Finding missing TB cases in Northern Nigeria

Public Health Action
SETTING: Despite recent progress in TB notification rates, 6.2% of the 3.1 million ‘missing’ people with TB globally are from Nigeria. Identifying these ‘missing’ cases will improve TB control efforts in Nigeria.
S.A. Omotayo, O. Chukwuogo, C. Ogbudebe, D. Egbule, P. Opara, T. Bot, E. Chukwu, P. Nwadike, I. Gordon, C. Ezekhaigbe, A. Yakubu, B. Odume   +11 more
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source