Results 41 to 50 of about 238,637 (182)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Annals of Mechnikov's InstituteIntroduction: Tuberculosis (TB) and human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) comprise the major burden of infectious disease in resource-limited countries.
Kriti Gupta +3 more
doaj +1 more source
, 2020 "Document adapté du département de la Santé du Minnesota, Programme de prévention et de contrôle de la tuberculose.""OHA 8346 (01/2020)"--Page 2.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents ...
core
Passive Versus Active Tuberculosis Case Finding and Isoniazid Preventive Therapy Among Household Contacts in a Rural District of Malawi. [PDF]
, 2003 SETTING: Thyolo district, rural Malawi. OBJECTIVES: To compare passive with active case finding among household contacts of smear-positive pulmonary tuberculosis (TB) patients for 1) TB case detection and 2) the proportion of child contacts aged under 6 ...
Zachariah, R +9 more
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
HIV & AIDS Review. International Journal of HIV-Related ProblemsIntroduction Human immunodeficiency virus (HIV)/tuberculosis (TB) co-infection has become huge barrier to achieving TB control in the world. TB, despite being discovered in 1882, remains a major public health problem in many developing countries.
Parth U. Patel +2 more
doaj +1 more source
, 2020 "OHA 8346 (01/2020)"--Page 2.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Mode of access: Internet from
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
TB or not TB! That's the question
The Pan African Medical Journal, 2019 Twenty seven years old lady presented to the emergency department accompanied by family members with complaint of fluctuating consciousness and fever for the past three days.
Ahmed Nugud, Assmaa Nugud
doaj +1 more source
Ripped from the headlines: how can we harness communications to control TB? [PDF]
, 2007 Even 125 yrs after Robert Koch discovered the tuberculosis (TB) bacillus and 63 yrs since the discovery of streptomycin, the first anti-TB drug, TB, the ‘‘white plague’’, still causes ,9 million incidents of illness and claims .1.6 million lives annually.
CIRILLO DM +4 more
core +1 more source