Results 91 to 100 of about 192,044 (290)

Lifelong behavioral and neuropathological consequences of repetitive mild traumatic brain injury [PDF]

, 2017
Objective: Exposure to repetitive concussion, or mild traumatic brain injury (mTBI), has been linked with increased risk of long-term neurodegenerative changes, specifically chronic traumatic encephalopathy (CTE).
Acker, Christopher M., Ait-Ghezala, Ghania, Bachmeier, Corbin, Crawford, Fiona, Crynen, Gogce, Davies, Peter, Ferguson, Scott, Mouzon, Benoit C., Mullan, Michael, Ojo, Joseph O., Paris, Daniel, Stewart, William   +11 more
core   +2 more sources

An algorithm for seizure detection in rodents

Epilepsia Open, EarlyView.
Abstract Objective Epilepsy animal research often relies on long‐term intracranial electroencephalographic (iEEG) recordings. Here, we describe an artificial neural network (ANN) algorithm for automatic detection of seizures. Methods The algorithm was trained on iEEG recordings of three mouse models of chronic epilepsy: (1) the pilocarpine model of ...
Lyna Kamintsky, Gerben van Hameren, Itai Weissberg, Pooyan Moradi, Ofer Prager, Alaa Abu Ahmad, Lior Schori, Albert Becker, Yaniv Zigel, Alon Friedman   +9 more
wiley   +1 more source

Fast ripple‐delta coupling as an early biomarker for post‐traumatic epileptogenesis in repetitive brain injury

Epilepsia Open, EarlyView.
Abstract Objective Traumatic brain injury (TBI) can induce posttraumatic epilepsy (PTE), but early biomarkers for epileptogenesis are lacking. We aimed to investigate electrographic biomarkers before and during posttraumatic seizure development. Methods We used a repetitive diffuse TBI model in mice with continuous video‐EEG monitoring up to 4½ months ...
Oleksii Shandra, Dzenis Mahmutovic, Biswajit Maharathi, Md Adil Arman, Michael J. Benko, Owen Leitzel, Pritom Kumar Saha, Stefanie Robel   +7 more
wiley   +1 more source

Tanshinone IIA Promotes M2 Microglia by ERβ/IL-10 Pathway and Attenuates Neuronal Loss in Mouse TBI Model

Neuropsychiatric Disease and Treatment, 2020
Mingrui Chen,1 Qiulin Chen,1 Tao Tao2 1Department of Neurosurgery, Chongqing Red Cross Hospital (People’s Hospital of Jiangbei District), Jiangbei, Chongqing 400020, People’s Republic of China; 2Department of Rehabilitation Medicine, Guizhou ...
Chen M, Chen Q, Tao T
doaj  

Expansion of a fly TBI model to four levels of injury severity reveals synergistic effects of repetitive injury for moderate injury conditions

Fly, 2019
Several million traumatic brain injury (TBI) events are reported in the United States annually. However, mild TBI events often go unreported, and mild and repetitive mild TBI conditions are challenging to model. Fruit flies (Drosophila melanogaster) have
Lauren J Putnam, Ashley M Willes, Brooke E Kalata, Nathaniel D Disher, Douglas J Brusich   +4 more
doaj   +1 more source

Prognostic value of early magnetic resonance imaging in dogs after traumatic brain injury: 50 cases [PDF]

, 2014
Retrospective study of dogs with TBI that underwent 1.5T MRI within 14 days after head trauma. MRI evaluators were blinded to the clinical presentation, and all images were scored based on an MRI grading system (Grade I [normal brain parenchyma] to Grade
Asikainen, Bazarian, Bigler, Brain Trauma Foundation, Byrne, Chew, Englander, Firsching, Frey, Friedenberg, Hicks, Hilario, Kearsley-Fleet, Klein, Kornegay, Lagares, Lannsjö, Lee, Lowenstein, Löscher, Management of Concussion/mTBI Working Group, McDonald, Mittl, Orrison, Pearl, Platt, Sande, Schwartz-Porsche, Shenton, Shores, Simpson, Skandsen, Steinmetz, Tanoue, Vespa, Wendt-Hornickle, Wilde, Yuh, Zuercher   +38 more
core   +2 more sources

Harnessing Piezoelectric Biomaterials for Pathogenic Eradication and Tissue Regeneration

Exploration, EarlyView.
This review highlights recent advances in piezoelectric biomaterials for antibacterial therapy and tissue regeneration, discussing material classifications, catalytic mechanisms, property enhancements, biomedical applications, and future challenges in clinical translation.
Wenxuan Mao, Xiaoye Li, Ao He, Meng Ding, Yu Zhang, Zhuo Dai, Qiang Li, Weijun Xiu, Yanling Hu, Yongbin Mou, Dongliang Yang, Heng Dong   +11 more
wiley   +1 more source

In vivo metabolic imaging of Traumatic Brain Injury. [PDF]

, 2017
Complex alterations in cerebral energetic metabolism arise after traumatic brain injury (TBI). To date, methods allowing for metabolic evaluation are highly invasive, limiting our understanding of metabolic impairments associated with TBI pathogenesis ...
Chaumeil, Myriam M, Chou, Austin, Feng, Xi, Guglielmetti, Caroline, Krukowski, Karen, Najac, Chloe, Riparip, Lara-Kirstie, Rosi, Susanna   +7 more
core   +2 more sources

Potential neuroprotective and therapeutic agents and their mechanisms for irradiation‐induced brain injury

Ibrain, EarlyView.
In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard, Vivian Kapio Abem, Sagor Kumar Roy   +2 more
wiley   +1 more source

SNTF immunostaining reveals previously undetected axonal pathology in traumatic brain injury [PDF]

, 2015
Diffuse axonal injury (DAI) is a common feature of severe traumatic brain injury (TBI) and may also be a predominant pathology in mild TBI or “concussion”.
Cullen, D. Kacy, Johnson, Victoria E., Siman, Robert, Smith, Douglas H., Stewart, William, Weber, Maura T.   +5 more
core   +1 more source