Results 61 to 70 of about 192,044 (290)

Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes

Advanced Science, EarlyView.
Stochastic nanoscale physical cues induce glioblastoma (GBM)‐associated transcriptional traits in naïve astrocytes leading to spontaneous formation of spheroids. Cells within spheroids express activated‐MMP2 and a differential gene expression pattern involving P53 and NOTCH3, providing evidence for a role for changes in brain topography, as observed in
Laurent Starck, Tobias Butelmann, Sabrina Hogan, Melika Sarem, Bernd Heimrich, Ritwick Sawarkar, Marie‐Françoise Ritz, Gregor Hutter, V. Prasad Shastri   +8 more
wiley   +1 more source

Inhibition of NOX2 contributes to the therapeutic effect of aloin on traumatic brain injury

Folia Neuropathologica, 2020
Traumatic brain injury (TBI) is a subset of brain injury induced by external mechanical forces to the head or neck. TBI has been reported to be one of the leading causes of disability, and it causes a huge financial burden around the world.
Haihai Dong, Haitao Wang, Xuezhi Zhang
doaj   +1 more source

Enhanced pre-frontal functional-structural networks to support postural control deficits after traumatic brain injury in a pediatric population [PDF]

, 2017
Traumatic brain injury (TBI) affects the structural connectivity, triggering the re-organization of structural-functional circuits in a manner that remains poorly understood.
Bonifazi, Paolo, Cortes, Jesus M, Diez, Ibai, Drijkoningen, David, Gooijers, Jolien, Marinazzo, Daniele, Stramaglia, Sebastiano, Swinnen, Stephan P   +7 more
core   +3 more sources

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

Advanced Science, EarlyView.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du, Rui Deng, Ya Wu, Hong‐Xia Ren, Zong‐Hong Lin, Yang‐Bao Miao   +5 more
wiley   +1 more source

A workflow to explore elongase diversity and extend the repertoire of fatty acids produced by Yarrowia lipolytica

Microbial Cell Factories
Background Fatty acids display highly diverse structures that confer these molecules unique chemical properties and distinct physiological functions.
Jérémy Le Reun, Zélie Salvioli, Christian Croux, Jérémy Esque, Isabelle André, Florence Bordes   +5 more
doaj   +1 more source

Modelling the benefits of urine source separation scenarios on wastewater treatment plants within an urban water basin

Water Science and Technology, 2022
Stringent discharge regulations are encouraging researchers to create innovative and sustainable wastewater treatment solutions. Urine source separation (USS) is among the potent approaches that may reduce nutrient peak loads in the influent wastewater ...
Gerald Matar, Mathilde Besson, Jennifer Mas, Sam Azimi, Vincent Rocher, Mathieu Sperandio   +5 more
doaj   +1 more source

Routine repeat head CT may not be necessary for patients with mild TBI. [PDF]

, 2018
Background:Routine repeat cranial CT (RHCT) is standard of care for CT-verified traumatic brain injury (TBI). Despite mixed evidence, those with mild TBI are subject to radiation and expense from serial CT scans.
Deane, Molly R, Luy, Diego D, Rosen, Claire B, Scalea, Thomas M, Stein, Deborah M   +4 more
core   +2 more sources

Ferroptosis‐Mediated Hippocampal Neuronal Loss Post‐mTBI: Chromatin Accessibility Profiling and Single‐Nucleus Transcriptomics

Advanced Science, EarlyView.
Hippocampal single ‐nucleus transcriptomes and chromatin accessibility after mild traumatic brain injury reveal dentate granule neuron vulnerability driven by ferroptosis. The c‐Jun–Tmsb4x–Slc2a2 axis modulates lipid peroxidation and iron dysregulation.
Manrui Li, Qiuyun Yang, Shengqiu Qu, Yang Chen, Yang Shen, Yang Xu, Xilong Lin, Yihan Sun, Ying Chen, Meili Lv, Lin Zhang, Zengqiang Yuan, Weibo Liang, Xiameng Chen   +13 more
wiley   +1 more source

One-hundred years (and counting) of blast-associated traumatic brain injury [PDF]

, 2018
Blast-associated traumatic brain injury (TBI) has become one of the signature issues of modern warfare and is increasingly a concern in the civilian population due to a rise in terrorist attacks.
Fullerton, Josephine L., Kinch, Kevin, Stewart, William   +2 more
core   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source