Results 121 to 130 of about 46,097 (206)

Reshaping CAR-T cells through overexpression of T cell factor 1

Frontiers in Immunology
IntroductionAlthough chimeric antigen receptor (CAR) T cell therapy has revolutionized treatment for hematologic malignancies, insufficient CAR-T cell persistence remains a major limitation. T cell factor 1 (TCF-1) is a transcription factor crucial for T
Hao Yao, Hao Yao, Yuntian Ding, Yuntian Ding, Yuntian Ding, Qian Chen, Qian Chen, Huixiu Han, Huixiu Han, David Sedloev, David Sedloev, Carsten Müller-Tidow, Carsten Müller-Tidow, Tim Sauer, Tim Sauer, Anita Schmitt, Anita Schmitt, Michael Schmitt, Michael Schmitt, Lei Wang, Lei Wang   +20 more
doaj   +1 more source

TCF limits mitochondrial damage and increases Atgl levels.

, 2018
(A) Western blot analysis of protein carbonyls in crude mitochondria from different tissues of mice fed with HFD/ND or HFD/TCF. vDAC1 was used as loading control.
Katia Aquilano (5194175), Viviana Casagrande (5194184), Daniele Lettieri-Barbato (5194181), Maria Rosa Ciriolo (39820), Stefano Maria Cannata (5194178)   +4 more
core   +1 more source

CLDN18.2 in pancreatic ductal adenocarcinoma: Biomarker assessment, spatial heterogeneity and therapeutic modality selection

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
This review presents a framework for selecting Claudin 18.2 (CLDN18.2)‐directed treatment modalities in pancreatic ductal adenocarcinoma according to tumour antigen coverage and spatial distribution. Representative assessment at baseline and reassessment after progression can guide treatment adaptation over time.
Ruyu Tan, Zhexin Zhang, Jiaxin Wang, Roland Andersson, Daniel Ansari, Jinfei Chen   +5 more
wiley   +1 more source

Mitigating Stress‐Induced Nonphotoactive Phase Transition Through Sodium Sulfonate Engineering for Stable and Efficient Perovskite Solar Cells

Angewandte Chemie, Volume 138, Issue 40, 28 September 2026.
To address the phase stability issue of α‐FAPbI3, we employed a cation doping strategy using 1‐decanesulfonate (C10H21NaO3S). This doping releases lattice strain and suppresses the formation of the δ‐phase, enabling breakthrough performance in perovskite solar cells with a power conversion efficiency of 26.67% and excellent thermal and photostability ...
Zhihuan Tang, Mingzi Sun, Jinghao Ge, Ying Wang, Yunfan Wang, Yiran Tao, Lu Zhang, Xinhui Lu, Sai‐Wing Tsang, Weizhong Tian, Rui Wang, Hao‐Chung Kuo, Bolong Huang, Shengzhong (Frank) Liu, Jiaxue You, Alex K. Y. Jen   +15 more
wiley   +2 more sources

Suppression of neointima formation by targeting β-catenin/TCF pathway

, 2020
Synopsis Coronary artery disease is treated by vein grafting and stent implantation. Late vein graft failure and restenosis of stented arteries reduce the success rates of these approaches and are caused by neointima formation.
Sadie Slater, Helen Williams, Sarah Jane George   +2 more
core  

Data_Sheet_1_Long Wavelength TCF-Based Fluorescent Probe for the Detection of Alkaline Phosphatase in Live Cells.docx

, 2019
A long wavelength TCF-based fluorescent probe (TCF-ALP) was developed for the detection of alkaline phosphatase (ALP). ALP-mediated hydrolysis of the phosphate group of TCF-ALP resulted in a significant fluorescence “turn on” (58-fold), which was ...
Jordan E. Gardiner (1852726), Steven D. Bull (1652206), Adam C. Sedgwick (1652203), John P. Lowe (1309878), Jonathan L. Sessler (527319), Tony D. James (1430470), George T. Williams (5860349), Gyoungmi Kim (1635565), Jean-Yves Maillard (308999), A. Toby A. Jenkins (6647006), Lauren Gwynne (6647003), Juyoung Yoon (214704)   +11 more
core   +1 more source

Femtosecond‐Laser‐Inscribed Cladding Fiber Bragg Gratings: Architectures, Design Trade‐Offs and Future Sensing Opportunities

Laser &Photonics Reviews, Volume 20, Issue 19, 7 October 2026.
Femtosecond‐laser inscription enables precise positioning of fiber Bragg gratings within the cladding, introducing new spatial and modal design freedoms. Auxiliary‐waveguide, near‐core evanescent‐field, and direct cladding‐mode‐excitation architectures provide complementary pathways toward multiparameter, vector, distributed, and environmentally ...
Koustav Dey, Rex E. Gerald, Chen Zhu, Jie Huang   +3 more
wiley   +1 more source

Hippo Pathway–YAP/TAZ Signaling: Molecular Mechanisms, Biological Function, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
The Hippo–YAP/TAZ–TEAD pathway integrates mechanical and biochemical cues to govern organ growth, regeneration, cancer, and fibrosis. This review dissects pathway physiology, TEAD structural pharmacology and ligandable pockets, and therapeutic strategies spanning palmitoylation‐pocket inhibitors, PROTAC degraders, and gene/RNA therapies, highlighting ...
Xiaodan Qu, Zhan‐you Wang
wiley   +1 more source

AWT/AWDE Probabilistic TCF Demo [PDF]

Presented to: AWCNational Oceanic and Atmospheric Administration\u2019s (NOAA) Aviation Weather Testbed (AWT) hosted the 2020 Virtual Summer Experiment August 3-14, 2020.
United States. Federal Aviation Administration. NextGen Human Factors Division, United States. Department of Transportation. Federal Aviation Administration. Aviation Weather Demonstration and Evaluation (AWDE)   +1 more
core  

Piper nigrum Has an Antitumor Effect Through Regulation of the Phosphatidylinositol 3‐Kinase Signaling Pathway in a Murine Model of Acute Myeloid Leukemia

Phytotherapy Research, Volume 40, Issue 10, Page 5988-6004, October 2026.
Overview of the antileukemic effects of Piper nigrum extract in AML. P. nigrum reduced leukemic cell proliferation and glycolytic metabolism through modulation of the PI3K/AKT/mTOR pathway. In vivo, treatment reduced leukemic burden, improved hematological parameters, prolonged survival, and modulated antitumor immune responses.
Natalia Murillo, Paola Lasso, Claudia Urueña, Susana Fiorentino   +3 more
wiley   +1 more source