TCF 4 tumor suppressor: a molecular target in the prognosis of sporadic colorectal cancer in humans [PDF]
Cellular & Molecular Biology Letters, 2020 Background A huge array of function is played by the Wnt/β-catenin signaling pathway in development by balancing gene expression through the modulation of cell-specific DNA binding downstream effectors such as T-cell factor/lymphoid enhancer factor (TCF ...
Mumtaz Anwar +6 more
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miR-152 Attenuates Apoptosis in Chondrocytes and Degeneration of Cartilages in Osteoarthritis Rats via TCF-4 Pathway [PDF]
Dose-Response, 2020 Introduction: Osteoarthritis (OA) is associated with deregulation of various miRNAs (miRs). The present study reported protective effect of miR-152 in osteoarthritis.
Daqian Wan +3 more
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The β-catenin/TCF-4 pathway regulates the expression of OPN in human osteoarthritic chondrocytes [PDF]
Journal of Orthopaedic Surgery and Research, 2020 Background Cartilage destruction is the main characteristic of osteoarthritis (OA), and osteopontin (OPN) is elevated in OA articular cartilage; however, the reason for the increased OPN level is not determined.
Jian Tian +6 more
doaj +2 more sources
VE-Cadherin modulates β-catenin/TCF-4 to enhance Vasculogenic Mimicry [PDF]
Cell Death and Disease, 2023 Vasculogenic Mimicry (VM) refers to the capacity to form a blood network from aggressive cancer cells in an independent way of endothelial cells, to provide nutrients and oxygen leading to enhanced microenvironment complexity and treatment failure.
Daniel Delgado-Bellido +11 more
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miR-26b-5p/TCF-4 Controls the Adipogenic Differentiation of Human Adipose-derived Mesenchymal Stem Cells [PDF]
Cell Transplantation, 2020 In this study, we assessed the ability of miR-26b-5p to regulate T cell factor 4 (TCF-4) expression and thereby control human adipose-derived mesenchymal stem cell (hADMSC) adipogenic differentiation.
Yadong Luo +10 more
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A Novel Drug, CC-122, Inhibits Tumor Growth in Hepatocellular Carcinoma through Downregulation of an Oncogenic TCF-4 Isoform [PDF]
Translational Oncology, 2019 Immunomodulatory drugs such as lenalidomide (LEN) have shown significant anti-tumor activity against hematologic malignancies and they may have similar actions on solid tumors as well.
Yoshito Tomimaru +4 more
doaj +2 more sources
Roles of β-catenin, TCF-4, and survivin in nasopharyngeal carcinoma: correlation with clinicopathological features and prognostic significance [PDF]
Cancer Cell International, 2019 Background Nasopharyngeal carcinoma (NPC) is a common malignant tumor of the head and neck region with poorly understood progression and prognosis. The present study aims at exploring whether the expression of β-catenin, TCF-4, and survivin affects ...
Pei-Ying Jin +7 more
doaj +2 more sources
MicroRNA‐379 inhibits laryngeal carcinoma cell proliferation and invasion through directly targeting TCF‐4 [PDF]
Kaohsiung Journal of Medical Sciences, 2019 The expression pattern, functions, and detailed regulatory mechanisms of miR‐379 in laryngeal carcinoma remain unknown. In the present study, we aimed to uncover novel potential miR‐379 targets and shed light on its roles in laryngeal carcinoma.
Jin‐Long Wei +5 more
doaj +2 more sources
KIFC1 is activated by TCF-4 and promotes hepatocellular carcinoma pathogenesis by regulating HMGA1 transcriptional activity [PDF]
Journal of Experimental & Clinical Cancer Research, 2019 Background Kinesins play important roles in the development and progression of many human cancers. The functions and underlying mechanisms of kinesin family member C1 (KIFC1), a member of the kinesin-14 family, in the pathogenesis of hepatocellular ...
Kai Teng +10 more
doaj +2 more sources
Lower Nr5a2 Level Downregulates the β-Catenin and TCF-4 Expression in Caerulein-Induced Pancreatic Inflammation [PDF]
Frontiers in Physiology, 2020 Nuclear receptor subfamily 5 group A member 2 (Nr5a2) is widely involved in the physiological and pathological processes of the pancreas. However, the cytological and molecular evidence regarding how Nr5a2 implicated in acute pancreatitis (AP) remains ...
Ya Mei Sun +9 more
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