GRG5/AES interacts with T-cell factor 4 (TCF4) and downregulates Wnt signaling in human cells and zebrafish embryos. [PDF]
PLoS ONE, 2013 Transcriptional control by TCF/LEF proteins is crucial in key developmental processes such as embryo polarity, tissue architecture and cell fate determination.
Angela M Sousa Costa +5 more
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The responses of neural stem cells to the level of GSK-3 depend on the tissue of origin
Biology Open, 2013 Summary Neural stem cells (NSCs) can be obtained from a variety of sources, but not all NSCs exhibit the same characteristics. We have examined how the level of glycogen synthase kinase-3 activity regulates NSCs obtained from different sources: the mouse
Tamara Holowacz +6 more
doaj +1 more source
Human FasL gene is a target of β-catenin/T-cell factor pathway and complex FasL haplotypes alter promoter functions. [PDF]
PLoS ONE, 2011 FasL expression on human immune cells and cancer cells plays important roles in immune homeostasis and in cancer development. Our previous study suggests that polymorphisms in the FasL promoter can significantly affect the gene expression in human cells.
Jianming Wu +9 more
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Molecules, 2020 Thymus vulgaris and Arctium lappa have been used as a folk remedy in the Iraqi Kurdistan region to deal with different health problems. The aim of the current study is to investigate the cytotoxicity of T. vulgaris and A.
Aveen N. Adham +3 more
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Scientific Reports, 2021 Prostate cancer (PCa) morbidity in the majority of patients is due to metastatic events, which are a clinical obstacle. Therefore, a better understanding of the mechanism underlying metastasis is imperative if we are to develop novel therapeutic ...
Mineon Park +7 more
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AKT1 and AKT2 Promote Malignant Transformation in Human Brain Glioma LN229 Cells
Cancer Biology & Medicine, 2011 OBJECTIVE To confirm the role played by AKT1 and AKT2 in the b-catenin/Tcf-4 signaling pathway in promoting malignant transfor-mation of glioma cells.METHODS LN229 cells were divided into five groups: a control group, acetone (ACE)group ...
Jian Zou +6 more
doaj +1 more source
Progesterone receptor membrane component 1 and its role in ovarian follicle growth
Frontiers in Neuroscience, 2013 Progesterone (P4) is synthesized in the ovary and acts directly on granulosa cells of developing ovarian follicles to suppress their rate of mitosis and apoptosis. Granulosa cells do not express nuclear progesterone receptor (PGR) but rather progesterone
John J Peluso
doaj +1 more source
Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo [PDF]
, 2006 The transcription factors lymphoid enhancer binding factor 1 (LEF1) and transcription factor 7 (TCF7) (T cell factor-1 (TCF-1)) are downstream effectors of the WNT signaling pathway, which is a critical regulator of T cell development in the thymus.
Freeman, Tom +5 more
core
Human immunodeficiency virus type 1 Tat prevents dephosphorylation of Sp1 by TCF-4 in astrocytes
, 2006 Previous examination of the effect of TCF-4 on transcription of the human immunodeficiency virus type 1 (HIV-1) promoter in human astrocytic cells found that TCF-4 affects the HIV-1 promoter through the GC-rich domain (nt -80 to nt -68).
Pasquale Ferrante +5 more
core +1 more source
Konservierte und nicht-konservierte Funktionen der Lef/Tcf Transkriptionsfaktoren [PDF]
, 2012 Die Lef/Tcf Transkriptionsfaktoren sind die nukleären Mediatoren des Wnt-Signalwegs. In allen bisher untersuchten Invertebraten liegt je nur ein Ortholog vor.
Klingel, Susanne
core +1 more source