Translational Oncology, 2023 This study aimed to determine the expression levels of runt-related transcription factor 3 (RUNX3) and caudal-related homeobox 2 (CDX2) in patients with chronic gastritis, intestinal metaplasia, atypical hyperplasia, and gastric cancer (GC).
Hui Liu +3 more
doaj +1 more source
Wnt/beta-catenin/Tcf signaling: A critical pathway in gastrointestinal tumorigenesis [PDF]
, 2002 Cancers of the gastrointestinal tract, including the liver, bile ducts, and pancreas, constitute the largest group of malignant tumors. Colorectal cancer is one of the most common neoplastic diseases in Western countries and one of the leading causes of ...
Bommer, G. +5 more
core +1 more source
Positive feedback regulation between phospholipase D and Wnt signaling promotes Wnt-driven anchorage-independent growth of colorectal cancer cells. [PDF]
PLoS ONE, 2010 BACKGROUND: Aberrant activation of the canonical Wnt/beta-catenin pathway occurs in almost all colorectal cancers and contributes to their growth, invasion and survival.
Dong Woo Kang, Do Sik Min
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TCF-4 Microsatellite Instability Mutation and Expression of Splicing Forms in Human Bladder Cancer [PDF]
, 2010 T cell factor (TCF)-4 and β-catenin are well recognized as key regulators in many developmental processes. TCF-4 binding with β-catenin can activate the transcriptional activity of downstream target genes (e.g. c-myc and cyclin-D1). Upregulation of TCF/β-
Chang, Huoy-Rou +11 more
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Tumor Response TCF-4/β-Catenin Regulatory Elements for Enhancing Cancer Gene Therapies [PDF]
, 2005 Mutations in the adenomatous polyposis coli gene are frequently associated with progression of colon carcinoma and most other types of epithelial carcinomas.
Gupta, Saurabh Kumar
core +1 more source
Characterization of sequences in human TWIST required for nuclear localization
BMC Cell Biology, 2009 Background Twist is a transcription factor that plays an important role in proliferation and tumorigenesis. Twist is a nuclear protein that regulates a variety of cellular functions controlled by protein-protein interactions and gene transcription events.
Gramolini Anthony O, Singh Shalini
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A satellite data driven biophysical modeling approach for estimating northern peatland and tundra CO2 and CH4 fluxes [PDF]
Biogeosciences, 2014 The northern terrestrial net ecosystem carbon balance (NECB) is contingent on inputs from vegetation gross primary productivity (GPP) to offset the ecosystem respiration (Reco) of carbon dioxide (CO2) and methane (CH4) emissions, but an effective ...
J. D. Watts +9 more
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Subfunctionalization and neofunctionalization of vertebrate Lef/Tcf transcription factors [PDF]
, 2012 Invertebrates express a multitude of Wnt ligands and all Wnt/β-catenin signaling pathways converge to only one nuclear Lef/Tcf. In vertebrates, however, four distinct Lef/Tcfs, i.e. Tcf-1, Lef, Tcf-3, and Tcf-4 fulfill this function.
Klingel, Susanne +5 more
core +1 more source
β-catenin modulates HIV transcription in CD4+ T cells via TCF-4 binding at the LTR.
, 2022 (A) Schematic showing the -143 TCF-4 binding site relative to other transcription factor binding sites on the HIV LTR and with HXB2 numbering, and the LTR luciferase reporter plasmid constructs, containing deleted TCF binding sites shown with X marks at ...
Jennillee Wallace (553258) +6 more
core +1 more source
PLoS ONE, 2009 Reduced expression of Paneth cell antimicrobial alpha-defensins, human defensin (HD)-5 and -6, characterizes Crohn's disease (CD) of the ileum.
Maureen J Koslowski +19 more
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