Inhibition of Tcf-4 induces apoptosis and enhances chemosensitivity of colon cancer cells. [PDF]
PLoS ONE, 2012 Aberrant activation of β-catenin/Tcf-4 signaling has been implicated in human carcinogenesis, including colorectal cancer. In this study, we compared the effects of Tcf-4 knockdown with β-catenin knockdown on cell proliferation, apoptosis, and ...
Jiang Xie +7 more
doaj +2 more sources
ABCD2 is a direct target of β-catenin and TCF-4: implications for X-linked adrenoleukodystrophy therapy. [PDF]
PLoS ONE, 2013 X-linked adrenoleukodystrophy (X-ALD) is a peroxisomal disorder caused by mutations in the ABCD1 gene that encodes the peroxisomal ATP-binding cassette (ABC) transporter subfamily D member 1 protein (ABCD1), which is referred to as the ...
Chul-Yong Park +7 more
doaj +4 more sources
Axin downregulates TCF-4 transcription via β-catenin, but not p53, and inhibits the proliferation and invasion of lung cancer cells [PDF]
Molecular Cancer, 2010 Background We previously reported that overexpression of Axin downregulates T cell factor-4 (TCF-4) transcription. However, the mechanism(s) by which Axin downregulates the transcription and expression of TCF-4 is not clear.
Miao Yuan +10 more
doaj +2 more sources
Control of TCF-4 expression by VDR and vitamin D in the mouse mammary gland and colorectal cancer cell lines. [PDF]
PLoS ONE, 2009 The vitamin D receptor (VDR) pathway is important in the prevention and potentially in the treatment of many cancers. One important mechanism of VDR action is related to its interaction with the Wnt/beta-catenin pathway.
Marcy E Beildeck +4 more
doaj +2 more sources
NF-κB p65 and TCF-4 interactions are associated with LPS-stimulated IL-6 secretion of macrophages [PDF]
Biochemistry and Biophysics ReportsProinflammatory cytokine plays a central role in host defense and acute inflammatory responses. Both positive and negative correlations of NF-κB and Wnt/β-catenin pathways have been reported depending on cell types in response to inflammatory stimuli for
Ji-Youn Kim +4 more
doaj +2 more sources
Translational Oncology, 2020 T-cell factor 4 (TCF-4) is determined to play a crucial role in Wnt/β-catenin signaling pathway activation. The mutations and alternative splice isoforms of TCF-4 can cause cancers and other diseases.
Hongjian Su +4 more
doaj +1 more source
TCF-1 limits intraepithelial lymphocyte antitumor immunity in colorectal carcinoma
, 2023 Intraepithelial lymphocytes (IELs), including αβ and γδ T cells (T-IELs), constantly survey and play a critical role in maintaining the gastrointestinal epithelium.
Maxine Smith (18223241) +25 more
core +1 more source
Critical role of TCF-1 in repression of the IL-17 gene. [PDF]
PLoS ONE, 2011 Overwhelming activation of IL-17, a gene involved in inflammation, leads to exaggerated Th17 responses associated with numerous autoimmune conditions, such as experimental autoimmune encephalomyelitis (EAE).
Jian Ma +4 more
doaj +1 more source
Loss of the SxxSS motif in a human T-cell factor-4 isoform confers hypoxia resistance to liver cancer: an oncogenic switch in Wnt signaling. [PDF]
PLoS ONE, 2012 Aberrantly activated Wnt/β-catenin signaling is important in hepatocellular carcinoma (HCC) development. Downstream gene expressions involving the Wnt/β-catenin cascade occur through T-cell factor (TCF) proteins.
Hironori Koga +8 more
doaj +1 more source
TPL-2 inhibits IFN-β expression via an ERK1/2-TCF-FOS axis in TLR4-stimulated macrophages.
, 2022 TPL-2 kinase plays an important role in innate immunity, activating ERK1/2 MAPKs in myeloid cells following TLR stimulation. We investigated how TPL-2 controls transcription in TLR4-stimulated mouse macrophages.
Erwin F Wagner (7953668) +7 more
core +1 more source