Results 61 to 70 of about 31,004 (197)

Successful Translational Prediction of Bedaquiline's Phase 2a Clinical Trial Results against Tuberculosis: The Zebrafish as a New Approach Methodology

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Tuberculosis remains an urgent global health crisis that requires an accelerated development of novel regimens. Rodent and rabbit studies currently inform early translational predictions. However, the zebrafish (Danio rerio) embryo/larva, as a New Approach Methodology, provides an ethical, cost‐effective, and high‐throughput non‐mammalian disease model
Bart van Lieshout   +3 more
wiley   +1 more source

Surveillance of transmitted HIV drug resistance among newly diagnosed, treatment-naive individuals at a county HIV clinic in Santa Clara County

open access: yesHeliyon, 2019
Introduction: To our knowledge, HIV transmitted drug resistance (TDR) patterns have not been characterized specifically in Santa Clara County (SCC), California, one of the largest counties by population in the United States.
William Chan, Wilson Ly
doaj   +1 more source

Increase of transmitted drug resistance among HIV-infected sub-Saharan Africans residing in Spain in contrast to the native population. [PDF]

open access: yesPLoS ONE, 2011
BackgroundThe prevalence of transmitted HIV drug resistance (TDR) is stabilizing or decreasing in developed countries. However, this trend is not specifically evaluated among immigrants from regions without well-implemented antiretroviral strategies ...
Gonzalo Yebra   +7 more
doaj   +1 more source

Co‐Catalyst/Semiconductor Interface Coupling Design for Efficient Solar‐Driven Photocatalysis

open access: yesEcoEnergy, EarlyView.
Interfacial coupling strength is proposed as a unifying descriptor governing charge‐transfer behavior in co‐catalyst/semiconductor photocatalytic systems. This review establishes a coupling‐strength‐guided framework that correlates interface engineering strategies with charge transport pathways, electronic structure regulation, and photocatalytic ...
Fangxu Dai   +7 more
wiley   +1 more source

Exploring TDR versus non-TDR genetic and geographic variation.

open access: yes, 2014
(A) Pair-wise genetic versus geographic distance for TDR and non-TDR viruses, and (B) TDR and non-TDR genetic distances by Rural/Urban pair relationship with median value indicated by a bar.
Michael Emch (103733)   +3 more
core   +1 more source

Common‐garden experimental evaluation of phylogenetic and functional diversity as drivers of plant performance

open access: yesOikos, EarlyView.
Biodiversity is known to influence the performance of coexisting species and has been proposed as a management tool to enhance the resilience and functioning of plant communities under drought. However, experimental studies to disentangle the roles of phylogenetic and functional diversity as drivers of plant performance remain extremely scarce.
Arantzazu L. Luzuriaga   +3 more
wiley   +1 more source

Do good neighbours compensate for bad climate? The case of sessile oak Quercus petraea in phylogenetically distant neighbourhoods

open access: yesOikos, EarlyView.
Stressful climates threaten the performance of individuals and the survival of species, but individual performance also depends on biotic interactions with neighbours, so that ‘good' neighbours might in theory compensate for ‘bad' climates. However, what makes a good neighbour, and why, has been little studied.
Keliang Zhang   +7 more
wiley   +1 more source

Integrated analysis of tRNA-derived small RNAs in proliferative human aortic smooth muscle cells

open access: yesCellular & Molecular Biology Letters, 2022
Background Abnormal proliferation of vascular smooth muscle cells (VSMCs) contributes to vascular remodeling diseases. Recently, it has been discovered that tRNA-derived small RNAs (tsRNAs), a new type of noncoding RNAs, are related to the proliferation ...
Jian-Zhi Zhao   +15 more
doaj   +1 more source

Innovations in polysaccharide‐based hydrogels in sustainable agriculture

open access: yesPolymer International, EarlyView.
Polysaccharide‐based hydrogels are promising in sustainable agriculture, as these natural polymers have the ability to absorb water and nutrients and release them gradually in the soil, in addition to ensuring biodegradability and lower cost. However, some challenges still need to be overcome.
Marcia Leticia Monteiro Gomes   +12 more
wiley   +1 more source

Impulse TDR and its application to measurement of antennas [PDF]

open access: yes, 2011
The traditional stimulus signal used in a time-domain reflectometer (TDR) is a voltage step. We propose an alternative technique, whereby an impulse generator is employed in place of the step generator in a TDR.
Scott, Jonathan B., McCabe, Steven Owen
core  

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