Results 201 to 210 of about 2,699,924 (238)

A phase 1 study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of PF‐07261271 in healthy participants

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim There is an unmet need for more effective therapies in inflammatory bowel disease (IBD). A single drug that blocks multiple distinct pathogenic pathways may offer therapeutic benefit superior to current monotherapies. PF‐07261271, a bispecific antibody targeting both the p40 subunit of interleukin‐12/23 and tumour necrosis factor‐like cytokine 1A ...
Srividya Neelakantan   +11 more
wiley   +1 more source

Development of a nalmefene formulation suitable for a community‐use auto‐injector

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim Time to onset of reversal is critical when treating opioid‐induced respiratory depression and hypoxia. This study aimed to develop a formulation of the opioid antagonist nalmefene with an increased absorption rate and reduced time to onset of reversal following intramuscular administration. Methods Several absorption enhancers were screened in rats,
Alessandra Cipriano   +6 more
wiley   +1 more source

Pharmacokinetics and safety of a modified‐release psilocybin formulation: A SAD Phase I trial in normal‐weight and overweight/obese participants

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to evaluate the safety, tolerability and pharmacokinetics of a novel oral modified‐release psilocybin formulation (REL‐P11) in normal‐weight and overweight/obese healthy adults and to assess its suitability for controlled, subperceptual exposure, in light of emerging evidence supporting serotonergic modulation in metabolic ...
Anna Signor   +11 more
wiley   +1 more source

<i>CsWRKY17</i> enhances Al accumulation by promoting pectin deesterification in tea plant. [PDF]

open access: yesHortic Res
Huang D   +8 more
europepmc   +1 more source

Flexible working and professional relationships in schools: An ecological approach

open access: yesBritish Educational Research Journal, EarlyView.
Abstract In English schools, the policy environment has recently moved considerably in favour of teachers taking planning, preparation and assessment (PPA) time away from the school site as one approach to flexible working in support of teacher retention.
Victoria Cook   +3 more
wiley   +1 more source

<i>CsUGT89A2</i> enhances tea plant resistance to <i>Toxoptera aurantia</i> by mediating flavonoid glycosides biosynthesis. [PDF]

open access: yesHortic Res
Zhou X   +13 more
europepmc   +1 more source

A repertoire of middle leading practices: A large‐scale investigation of middle leadership in schools

open access: yesBritish Educational Research Journal, EarlyView.
Abstract This article presents findings from an Australian study investigating the practices of middle leaders responsible for facilitating school development. Despite middle leaders being increasingly recognised as essential in the development of teaching and learning in schools, middle leadership remains under‐researched and comparatively overlooked ...
Peter Grootenboer   +3 more
wiley   +1 more source

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