Advanced Science, EarlyView.This study identifies L‐type calcium channel blockers as novel ferroptosis inhibitors. It reveals that PKCβ, activated in calcium dependent manner, phosphorylates and activates ACSL4 and ALOX15, relocating them to lipid droplets to promote lethal lipid peroxidation and ferroptosis.
Guoyuan Hou +8 more
wiley +1 more source
Implementing martial arts education in Chinese schools: teachers' perspectives on the school martial arts program. [PDF]
Front Sports Act LivingXue S, Ji H, Yang J, Zhao L, Su X.
europepmc +1 more source
Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism
Advanced Science, EarlyView.The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying +8 more
wiley +1 more source
Sustainable professional growth through digital mentorship: evidence from language teachers in low-resource settings. [PDF]
Sci RepHussain S, Debreli E, Farman M.
europepmc +1 more source
Imperfection in Semiconductors Leading to High Performance Devices
Advanced Science, EarlyView.Crystalline perfection is typically pursued in semiconductors to enhance device performance. However, through modeling and experimental work, we show that defects can be strategically employed in a specific detection regime to increase sensitivity to extreme values. GaN diodes are demonstrated to effectively detect high‐energy proton beams at fluxes as
Jean‐Yves Duboz +8 more
wiley +1 more source
Pathways to Wellbeing: Reconceptualizing Resilience to Foreground Marginalized Teachers' Agentic Resistance. [PDF]
Behav Sci (Basel)Hong J +6 more
europepmc +1 more source
Advanced Science, EarlyView.This work introduces a substrate‐independent, reagent‐free plasma strategy that forms radical‐rich interlayers for covalent hydrogel attachment without initiators or crosslinkers. The long‐lived radicals drive in situ gelation, creating robust, cytocompatible hybrid solid–hydrogel constructs across diverse substrates.
Ghazal Shineh +14 more
wiley +1 more source
Investigating the relationship between teacher efficacy, job satisfaction, and digital resource utilization in assessment practices: Insights from PISA 2018 and 2022. [PDF]
PLoS OneJoshi DR, Khanal J, Joshi BM.
europepmc +1 more source
Machine Learning for Green Solvents: Assessment, Selection and Substitution
Advanced Science, EarlyView.Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta +4 more
wiley +1 more source
From "teaching by word and deed" to "intelligent mentorship": ethical reconsiderations of AI-enabled medical education - lessons from China. [PDF]
Front Med (Lausanne)Hou Z, Chen J, Guo H.
europepmc +1 more source